Antibacterial monoterpenoid indole alkaloids from Alstonia scholaris cultivated in temperate zone

Acute and Chronic Toxicity of Indole Alkaloids from Leaves of Alstonia scholaris (L.) R. Br. in Mice and Rats

“…The leaves have long been used in "dai" ethno-pharmacy to treat postinfectious cough, chronic bronchitis, asthma, and other respiratory tract infections in Yunnan Province, China [6]. The authors of this paper have investigated intensively the phytochemical constituents of the different parts of the plant [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. The chemical profile and metabolites of alkaloidal extract of leaves of A. scholaris indicate that scholaricine, 19-epischolaricine, vallesamine, and picrinine are the major indole alkaloids [27,28].…”

Effects of indole alkaloids from leaf of Alstonia scholaris on post-infectious cough in mice

“…Its leaves have long been used in "dai" ethno-pharmacy for the treatment of whooping cough (post infectious cough), chronic bronchitis, asthma, and other respiratory tract infections in Yunnan Province, PR China (Compiling Group of Yunnan Traditional Chinese Medicine, 1977). Phytochemical constituents of different parts of the plant were investigated intensively by our group (Cai et al, 2010(Cai et al, , 2008a(Cai et al, , 2008b(Cai et al, , 2007Chen et al, 2016;Du et al, 2007aDu et al, , 2007bFeng et al, 2009Feng et al, , 2008Liu et al, 2015;Pan et al, 2016;Qin et al, 2015aQin et al, , 2015bXu et al, 2009;Yang et al, 2015aYang et al, , 2015bYang et al, , 2014aYang et al, , 2014bZhang et al, 2014;Zhou et al, 2005). Meanwhile, the chemical profiling and metabolites of alkaloidal extract of A. scholaris were reported (Cao et al, 2015), in which scholaricine, 19-epischolaricine, vallesamine, and picrinine were the major indole alkaloids of its leaf ( Fig.…”

Natural indole‐containing alkaloids and their antibacterial activities

“…Ormavacurine‐21‐one ( 27 ; MIC: 0.78, 1.56, and 6.25 µg/ml), isolated from the leaves of Alstonia scholaris , displayed a potential activity against E. faecalis , P. aeruginosa , and K. pneumonia , but the activity was lower than that of cefotaxime (MIC: 0.19–0.78 µg/ml). [ 53 ] A new strychnine alkaloid 28 (MIC: 0.78 µg/ml), isolated from the leaves of Psychotria pilifera , showed a similar activity as cefotaxime (MIC: 0.78 µg/ml) against E. coli . [ 54 ] Melokhanine A ( 29 ; MIC: 19–150 µg/ml), isolated from the twigs and leaves of Melodinus khasianus , possessed a broad‐spectrum activity against E. faecalis , P. aeruginosa , E. coli , S. aureus , and K. pneumonia , but the activity was far inferior to that of cefotaxime (MIC: 0.4–1.7 µg/ml).…”