Antibacterial peptides isolated from insects

Otvos, Jr Laszlo

doi:10.1002/1099-1387(200010)6:10<497::aid-psc277>3.0.co;2-w

Cited by 258 publications

(161 citation statements)

References 128 publications

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“…Likewise, when administrating post-Francisella tularensis infection, the cathelicidin-derived peptide LL-37 protects against respiratory tularemia in a murine model [6]. As opposed to the mammalian immune system that activates both innate and adaptive immunities, lower animals such as insects rely almost solely on a panel of AMP against bacteria in environments where these pathogens strive and are abundant [7]. Their importance gained widespread recognition in 2011, when Jules Hoffmann received the Nobel Prize in physiology or medicine for his pioneering work on innate immunity mechanisms, including identification of AMP from insects and discovery of the genetic background of their synthesis [8].…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory effects of anti-microbial peptides

Ötvös¹

2016

Acta Microbiologica et Immunologica Hungarica

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Anti-microbial peptides (AMPs) were originally thought to exert protecting actions against bacterial infection by disintegrating bacterial membranes. Upon identification of internal bacterial targets, the view changed and moved toward inhibition of prokaryote-specific biochemical processes. However, the level of none of these activities can explain the robust efficacy of some of these peptides in animal models of systemic and cutaneous infections. A rapidly growing panel of reports suggests that AMPs, now called host-defense peptides (HDPs), act through activating the immune system of the host. This includes recruitment and activation of macrophages and mast cells, inducing chemokine production and altering NF-κB signaling processes. As a result, both pro-and anti-inflammatory responses are elevated together with activation of innate and adaptive immunity mechanisms, wound healing, and apoptosis. HDPs sterilize the systemic circulation and local injury sites significantly more efficiently than pure single-endpoint in vitro microbiological or biochemical data would suggest and actively aid recovering from tissue damage after or even without bacterial infections. However, the multiple and, often opposing, immunomodulatory functions of HDPs require exceptional care in therapeutic considerations.

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Section: Introductionmentioning

confidence: 99%

Immunomodulatory effects of anti-microbial peptides

Ötvös¹

2016

Acta Microbiologica et Immunologica Hungarica

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“…Like any other group of social insects, honeybee colonies, with their rich store of food, abundant mass of immature brood and adults, suffer attack from numerous pathogens and parasites (Otvos, 2000;Evans and Spivak, 2010). Moreover, the constant and relatively high temperature and humidity levels maintained in a bee nest provide the perfect environment for the incubation of all kinds of microorganisms, such as protozoa, fungi, bacteria and viruses.…”

Section: Introductionmentioning

confidence: 99%

Evidence for antiseptic behaviour towards sick adult bees in honey bee colonies

Baracchi

Fadda

Turillazzi

2012

Journal of Insect Physiology

106

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a b s t r a c tSocial life is generally associated with an increased risk of disease transmission, but at the same time it allows behavioural defence at both the individual and collective level. Bees infected with deformed-wing virus were introduced into observation hives; through behavioural observations and chemical analysis of cuticular hydrocarbons from healthy and infected bees, we offer the first evidence that honeybee colonies can detect and remove infected adult bees, probably by recognising the cuticular hydrocarbon profiles of sick individuals. We also found that health-compromised colonies were less efficient at defending themselves against infected bees, thus facing an ever increasing risk of epidemics. This work reveals a new antiseptic behaviour that can only be interpreted as an adaptation at colony level and one which should be considered an element of the social immunity system of the beehive, re-enforcing the view of a colony as an integrated organism.

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“…The first defense of the colony against spreading of infectious diseases is represented by a set of hygienic behaviors (such as the elimination of corpses and organic wastes and the removal of infected insects from the nest), and by the use of fungicides and bactericides which may be produced by the colony members or be collected from plants [1]. As a further protection, the immune system of insects responds to microorganisms penetrating the body by releasing antimicrobial and antifungal peptides and proteins into the hemolymph [3][4][5][6]. Although the fat body is clearly the main source of the inducible antipathogenic peptides in insects [4], epidermis, including epithelial cells underlying cuticle, has also been demonstrated to produce antibacterial and antifungal peptides in response to local infections [7,8, and quotations reported therein].…”

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confidence: 99%

Dominulin A and B: Two new antibacterial peptides identified on the cuticle and in the venom of the social paper waspPolistes dominulususing MALDI-TOF, MALDI-TOF/TOF, and ESI-ion trap

Turillazzi

Mastrobuoni

Dani

et al. 2006

J. Am. Soc. Mass Spectrom.

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Two new antibacterial peptides, denominated as Dominulin A and B, have been found on the cuticle and in the venom of females of the social paper wasp Polistes dominulus. The amino acidic sequence of the two peptides, determined by mass spectrometry, is INWKKIAE VGGKIL SSL for Dominulin A (MW ϭ 1854 Da) and INWKKIAEIGKQVL SAL (MW ϭ 1909 Da) for Dominulin B. Their presence on the cuticle was confirmed using MALDI-TOF by means of micro-extractions and direct analyses on body parts. The presence in the venom and the primary structure of the dominulins suggest their classification in the mastoparans, a class of peptides found in the venom of other Aculeate hymenoptera. Their antimicrobial action against Gramϩ and GramϪ bacteria fits in the range of the best natural antimicrobial peptides. Dominulins can represent an important defense of the colony of Polistes dominulus against microbial pathogens. (J Am Soc Mass Spectrom 2006, 17, 376 -383)

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Antibacterial peptides isolated from insects

Cited by 258 publications

References 128 publications

Immunomodulatory effects of anti-microbial peptides

Immunomodulatory effects of anti-microbial peptides

Evidence for antiseptic behaviour towards sick adult bees in honey bee colonies

Dominulin A and B: Two new antibacterial peptides identified on the cuticle and in the venom of the social paper waspPolistes dominulususing MALDI-TOF, MALDI-TOF/TOF, and ESI-ion trap

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