Antibacterial Potential of 2,4-Di-tert-Butylphenol and Calixarene-Based Prodrugs from Thermophilic <i>Bacillus licheniformis</i> Isolated in Algerian Hot Spring

Aissaoui, Nadia; Mahjoubi, Mouna; Nas, Fatima; Mghirbi, Olfa; Arab, Mounia; Souissi, Yasmine; Hoceini, Amina; Masmoudi, Ahmed Slaheddine; Mosbah, Ahmed; Chérif, Ameur; Klouche-Khelil, Nihel

doi:10.1080/01490451.2018.1503377

Cited by 43 publications

(27 citation statements)

References 46 publications

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“…The composition of this fraction was more heterogeneous than the fraction SM♂L2-F6 (Table 4). The components, oxalic acid [59], 1-docosene [60], β-eudesmol [31] and phenol 2,4-di-tert-butyl- [47][48][49], are known, in the literature, for their correlation with antimicrobial activity, confirming the inhibitory effect found in our work.…”

Section: Discussionsupporting

confidence: 86%

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Antimicrobial Testing of Schinus molle (L.) Leaf Extracts and Fractions Followed by GC-MS Investigation of Biological Active Fractions

et al. 2020

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Schinus molle (L.) is a dioecious plant of the Anacardiaceae family, originating in South America and currently widespread in many regions throughout the world. In this work leaf extracts and derived low-pressure column chromatography (LPCC) fractions of S. molle L. male and female plants were investigated for the antimicrobial activity. Leaf extracts were tested on microbes Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis, Candida albicans and Bacillus subtilis. Furthermore, the extracts showing antimicrobial activity were fractionated by LPCC and the obtained fractions tested on the same microorganism strains. Positive fractions were investigated by gas-chromatography/mass spectrometry (GC-MS) and were seen to be rich in sesquiterpenes, sesquiterpenoids and other terpens. The obtained effects highlighted the antimicrobial properties of S. molle (L.) leaf compounds and revealed their importance as a source of bioactive molecules of potential pharmaceutical interest. To our knowledge, this is the first paper reporting investigations on the chemical composition of the extracts and derived positive fractions from Schinus molle (L.) plants grown in central Italy

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Section: Discussionsupporting

confidence: 86%

“…In particular, 2,4 DTBP is known to be an antifungal and cytotoxic molecule, as has been widely documented [46][47][48]. Aissaoui et al [49] also described the antibacterial potential of this compound.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Testing of Schinus molle (L.) Leaf Extracts and Fractions Followed by GC-MS Investigation of Biological Active Fractions

et al. 2020

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“…2,4-DTBP is a lipophilic phenol reported in at least 169 species of organisms (see Table 1). 2,4-DTBP was found in 16 species of bacteria in 10 families, such as nitrogen-fixing cyanobacteria [1]; Gram-positive bacteria in hot spring, soils, and food [2][3][4][5][6][7] and Gram-negative bacteria in soil and freshwater [8][9][10][11][12][13]. Some bacteria are causal agents of infectious diseases in humans, e.g., Microcystis aeruginosa Kützing, a species of freshwater cyanobacteria that produce neurotoxins and peptide hepatotoxins [12]; and Vibrio alginolyticus Miyamoto et al, a marine bacterium causing otitis and wound infection [13].…”

Section: Natural Sourcesmentioning

confidence: 99%

Natural Sources and Bioactivities of 2,4-Di-Tert-Butylphenol and Its Analogs

Zhao

Wang

Lucardi

et al. 2020

Toxins

197

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2,4-Di-tert-butylphenol or 2,4-bis(1,1-dimethylethyl)-phenol (2,4-DTBP) is a common toxic secondary metabolite produced by various groups of organisms. The biosources and bioactivities of 2,4-DTBP have been well investigated, but the phenol has not been systematically reviewed. This article provides a comprehensive review of 2,4-DTBP and its analogs with emphasis on natural sources and bioactivities. 2,4-DTBP has been found in at least 169 species of bacteria (16 species, 10 families), fungi (11 species, eight families), diatom (one species, one family), liverwort (one species, one family), pteridiphyta (two species, two families), gymnosperms (four species, one family), dicots (107 species, 58 families), monocots (22 species, eight families), and animals (five species, five families). 2,4-DTBP is often a major component of violate or essential oils and it exhibits potent toxicity against almost all testing organisms, including the producers; however, it is not clear why organisms produce autotoxic 2,4-DTBP and its analogs. The accumulating evidence indicates that the endocidal regulation seems to be the primary function of the phenols in the producing organisms.

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“…2,4 DTBP was found to be a microbial metabolite such as Streptomyces sp., Streptomyces mutabilis, Bacillus licheniformis, Bacillus subtilis, Pseudomonas monteilii, and Lactococcus sp. (Varsha et al, 2015;Dharni et al, 2014;Chawawisit et al, 2015;Belghit et al, 2016;Viszwapriya et al, 2016;Aissaoui et al, 2018). This compound shows the bactericidal agent to inhibit the growth of pathogenic bacteria, such as methicillin-resistant Staphylococcus aureus, group A streptococci and Pseudomonas aeruginosa.…”

Section: Discussionmentioning

confidence: 99%

“…This compound shows the bactericidal agent to inhibit the growth of pathogenic bacteria, such as methicillin-resistant Staphylococcus aureus, group A streptococci and Pseudomonas aeruginosa. 2,4 DTBP has fungicidal activity against Aspergillus niger, A. carbonarius, Fusarium oxysporum, Penicillium chrysogenum, Candida albicans and other pathogenic fungi (Varsha et al, 2015;Dharni et al, 2014;Chawawisit et al, 2015;Belghit et al, 2016;Viszwapriya et al, 2016;Aissaoui et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Peer Review #2 of "Organic acids and 2,4-Di-tert-butylphenol: major compounds of Weissella confusa WM36 cell-free supernatant against growth, survival and virulence of Salmonella Typhi (v0.2)"

2020

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Background. Salmonella Typhi (S. Typhi), the causative agent of typhoid fever, causes serious systemic disease in humans. Antibiotic treatment is required for the S. Typhi infection, while the inappropriate use of antibiotics causes increased drug-resistant S. Typhi. Hence, alternative therapies through nonantibiotic approaches are urgently needed. The use of beneficial lactic acid bacterium and/or its metabolites to control typhoid fever represent a promising approach, as it may exert protective actions through various mechanisms. Method. In this study, the cell-free culture supernatant (CFCS) of Weissella confusa WM36 was evaluated via the antibacterial activity, and its metabolites were identified. In addition, the effects of CFCS on Salmonella virulence behaviors were also investigated. Result. Based on strong inhibition the growth of S. Typhi DMST 22842, organic acids (lactic acid and acetic acid) and 2,4-Di-tert-butylphenol (2,4 DTBP), were the main antibacterial metabolites presented in CFCS of strain WM36. Minimum inhibitory concentration (MIC) at 40% WM36-CFCS dramatically reduced the S. Typhi population to more than 99.99% at 4 h and completely inhibited biofilm formation, while sub-MIC at 20% (v/v) and MIC could reduce 100% of motility. Additionally, sub-MIC at only 10% (v/v) WM36-CFCS did down-regulate the expression of virulence genes which are responsible for the type-III secretion system, effector proteins, and quorum sensing (QS) system in this pathogen. Conclusion. W. confusa WM36 and its metabolites are shown to be a promising candidates, and an effective approach against typhoid Salmonella burden.

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Antibacterial Potential of 2,4-Di-tert-Butylphenol and Calixarene-Based Prodrugs from Thermophilic Bacillus licheniformis Isolated in Algerian Hot Spring

Cited by 43 publications

References 46 publications

Antimicrobial Testing of Schinus molle (L.) Leaf Extracts and Fractions Followed by GC-MS Investigation of Biological Active Fractions

Antimicrobial Testing of Schinus molle (L.) Leaf Extracts and Fractions Followed by GC-MS Investigation of Biological Active Fractions

Natural Sources and Bioactivities of 2,4-Di-Tert-Butylphenol and Its Analogs

Peer Review #2 of "Organic acids and 2,4-Di-tert-butylphenol: major compounds of Weissella confusa WM36 cell-free supernatant against growth, survival and virulence of Salmonella Typhi (v0.2)"

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