Antibacterial Potential of Marine Brown Algae Turbinaria Conoides Against Bacteria Associated with Diabetic Foot Ulcer

Suresh, Thirunavukarasu Chitrikha; Poonguzhali, T. V.; Anuradha, V.; Bharathi, S.; Ramesh, B.; Suresh, G.

doi:10.22376/ijlpr.2023.13.2.l202-l210

Cited by 2 publications

(3 citation statements)

References 29 publications

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“…The study demonstrated that all four solvents extracted saponins, while steroids were present except methanol, and cardio glycosides were absent in the n-hexane extract. Overall, seaweeds, including S. wightii , are rich sources of biologically active compounds, making them valuable for various pharmaceutical and nutraceutical applications (Table 2 ) [ 14 ]. Among the phytoconstituents, polyphenols are compounds characterized by one or more aromatic rings with hydroxyl groups.…”

Section: Discussionmentioning

confidence: 99%

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Exploration of Sargassum wightii: Extraction, Phytochemical Analysis, and Antioxidant Potential of Polyphenol

Selvaraj,

Ganapathy

2024

Cureus

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Background The marine environment, with its rich biodiversity and nutrient-dense ecosystems, offers immense potential for discovering novel pharmaceutical products. Sargassum wightii is a type of brown seaweed that is particularly abundant in sulfated polysaccharides and polyphenolic compounds. These compounds are renowned for their wide range of biological activities. The exploration of such marine resources is crucial for identifying new compounds that can be harnessed for pharmaceutical and nutraceutical applications. Aims and objectives The primary aim of this study is to explore the bioactive compounds present in S. wightii , with a specific focus on its polyphenolic content. Additionally, the study seeks to evaluate the antioxidant properties of the compound. By doing so, the research aims to contribute to the growing body of knowledge on marine bioresources and their potential health benefits. Methods S. wightii samples were collected from the Mandapam coastal region in Rameshwaram, India. The cleaned seaweed was transported to the laboratory, where it was further washed, shade-dried, and ground into a fine powder. The powdered seaweed was then subjected to extraction using four different solvents: n-hexane, dichloromethane, ethyl acetate, and methanol. Phytochemical analyses were conducted on these extracts to identify the presence of various bioactive compounds. The total phenolic content of the extracts was determined, and antioxidant activity was assessed using the phosphomolybdenum method. Functional groups present in the extracts were identified using Fourier Transform Infrared (FT-IR) spectroscopy. Results Among the solvents used, the methanol extract yielded the highest amount of crude extract. Phytochemical analysis revealed a variety of bioactive compounds, with the methanol extract showing a notable presence of polyphenols. The total phenolic content was measured at 1.25 ± 0.6 mg gallic acid equivalence (GAE)/g of extract. The antioxidant activity, assessed through the phosphomolybdenum method, demonstrated significant free radical scavenging capabilities with an IC50 (half maximal inhibitory concentration) value of 68.23 ± 3.5 μg/mL. FT-IR spectroscopy confirmed the presence of functional groups characteristic of polyphenols and other bioactive compounds. Conclusion The study highlights the significant potential of S. wightii as a source of bioactive compounds with substantial antioxidant properties. These findings emphasize the importance of marine algae in the development of pharmaceutical and nutraceutical products, showcasing S. wightii's promising role in health-related applications.

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Section: Discussionmentioning

confidence: 99%

“…The mixture was filtered through Whatman filter paper no.4 and filtrate was allowed to evaporate. The extracts of respective solvents were used for further analysis [ 14 ]. The yield of 25 g powder was calculated by using the formula:…”

Section: Methodsmentioning

confidence: 99%

Exploration of Sargassum wightii: Extraction, Phytochemical Analysis, and Antioxidant Potential of Polyphenol

Selvaraj,

Ganapathy

2024

Cureus

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“…The plates were incubated at 37±2°C for 24hrs and antifungal assay plates were incubated at 28±2°C for 48hrs and every 24hrs the results were measured and tabulated. 37 The microdilution method determined Minimum inhibitory concentration using serially diluted (2 folds) plant extract according to the National Committee for Clinical Laboratory Standards. The dilution of B. monnieri determined the MIC of the extract with concentrations of 500, 250, 125, 62.5,31.25, 15.62, and 7.81μg/ml.…”

Section: Antimicrobial Activity 36mentioning

confidence: 99%

Analysis of Phytoconstituents and Antimicrobial Properties of Bacopa monnieri (L.) Against Clinical Pathogen

Amudha,

Magalingam,

Selvam

et al. 2023

Int J Life Sci Pharm Res

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There are numerous therapeutic uses for medicinal plants in treating and managing numerous diseases. Traditional medicinal plantswere mostly needed in the current scenario. The world's warmer and wetlands regions are home to the medicinal herb Bacopa monnieri (L.).It has been utilized for ages in Ayurvedic systems. The Bacopa monnieri was one of the traditional medicinal plants. These are commonlycalled "Brahmi," and the Tamil vernacular name is "Neerbrahmmi." It is easy to cultivate and grow in all seasons. These peculiar activeingredients, also known as memory enhancement and phytoconstituents were enriched in this medicinal plant. The present study focused onanalyzing phytoconstituents and the antimicrobial activity of Bacopa monnieri leaves. The efficacy of phytoconstituents on the antimicrobialactivities concerning minimum inhibitory concentrations was performed with different polar and non-polar solvents of the respective plant.The phytoconstituents such as alkaloids, amino acids, coumarins, flavonoids, glycosides, phenols, phlobatannins, quinones, reducing sugars,saponins, steroids, tannins, and terpenoids were recorded, respectively. Antibacterial activity performed with following human clinicalbacteria like Clostridium butyricum, Escherichia coli, Staphylococcus aureus, and Streptococcus pneumoniae, and the antifungal activity against humanclinical such as Aspergillus flavus, A.niger, Aspergillus sp., and Penicillium sp. were determined. Among the two solvent extractions, the aqueousextract showed a more significant result than the benzene extract. According to the MIC, the antimicrobial properties of B.monnieriwithdifferent extracts were analyzed. The very minimum concentration has shown better inhibitions against microbes. The present study exploredthe antimicrobial properties of human clinical pathogens. So, the B.monnieriaqueous extract of leaves was suggested for the treatment ofmicrobial infections.

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Antibacterial Potential of Marine Brown Algae Turbinaria Conoides Against Bacteria Associated with Diabetic Foot Ulcer

Cited by 2 publications

References 29 publications

Exploration of Sargassum wightii: Extraction, Phytochemical Analysis, and Antioxidant Potential of Polyphenol

Exploration of Sargassum wightii: Extraction, Phytochemical Analysis, and Antioxidant Potential of Polyphenol

Analysis of Phytoconstituents and Antimicrobial Properties of Bacopa monnieri (L.) Against Clinical Pathogen

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