Antibacterial Potential Of The Alpha-pinene Positive Enantiomer Against The Strain &lt;em&gt;Proteus mirabilis&lt;/em&gt;

Eduardo, Letícia de Sousa; Farias, Ticiane; Silva, Gildoberg; Lopes, Francisca Patrícia da; Ferreira, Sávio Benvindo

doi:10.3390/mol2net-03-04935

Cited by 3 publications

(4 citation statements)

References 5 publications

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“…Regarding the antimicrobial activities, various subspecies, including carota , hispanicus , maritimus , and maximus , have exhibited mild to moderate antibacterial properties against various bacterial species, aligning with their historical use in folk medicine as antiseptics for treating bacterial infections, such as prostatitis and cystitis [ 5 , 11 , 12 , 13 ]. Notably, α-pinene and geranyl acetate emerged as key constituents contributing to this antibacterial efficacy, which is in line with other studies that emphasize the antibacterial potential of α-pinene [ 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ]. While folk medicine does not explicitly mention the use of the wild carrot for fungal infections, multiple studies underscore its significant antifungal activities against diverse fungal strains, particularly within D. carota ssp.…”

Section: Discussionsupporting

confidence: 86%

“…In particular, the monoterpenes α-pinene, geranyl acetate, and sabinene, along with the sesquiterpene carotol, stand out as the most prominent constituents in different D. carota subspecies, exhibiting variable percentages. These compounds are noteworthy for their diverse pharmacological properties, including anti-inflammatory, antibacterial, and antifungal activities [ 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ]. Although the country of origin and the plant organ differ, most of the components are shared among all subspecies, with some exceptions that are clearly evident.…”

Section: Phytochemistry and Bioactive Compounds/chemical Compositionmentioning

confidence: 99%

“…Another study reported that α-pinene demonstrated activity against the Staphylococcus aureus, Staphylococcu epidermidis, Streptococcus pneumoniae, and Streptococcus pyogenes strains [60]. The antibacterial activity of α-pinene against various bacterial strains has been consistently reported in multiple studies [51][52][53][54][55][56][57][58][59][60]69].…”

Section: Antibacterial Activitymentioning

confidence: 99%

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The Wild Carrot (Daucus carota): A Phytochemical and Pharmacological Review

Ismail,

Shebaby,

Daher

et al. 2023

Plants

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Daucus carota L., a member of the Apiaceae family, comprises 13 subspecies, with one being cultivated (D. carota L. ssp. sativus (Hoffm.) Arcang.) and the remaining being wild. Traditionally, the wild carrot has been recognized for its antilithic, diuretic, carminative, antiseptic, and anti-inflammatory properties and has been employed in the treatment of urinary calculus, cystitis, gout, prostatitis, and cancer. While extensive literature is available on the phytochemical, pharmacological, and therapeutic evaluations of the cultivated carrot, limited information has been published on the wild carrot. A thorough search was conducted on the phytochemical composition, folk-medicine uses, and pharmacological properties of wild carrot subspecies (Daucus carota L. ssp. carota). Various electronic databases were consulted, and the literature spanning from 1927 to early 2023 was reviewed. Thirteen wild Daucus carota subspecies were analyzed, revealing over 310 compounds, including terpenoids, phenylpropenoids, flavonoids, and phenolic acids, with 40 constituting more than 3% of the composition. This review also highlights the antioxidant, anticancer, antipyretic, analgesic, antibacterial, antifungal, hypolipidemic, and hepato- and gastroprotective properties of wild carrot subspecies. Existing in vitro and in vivo studies support their traditional uses in treating infections, inflammation, and cancer. However, further research on other subspecies is required to confirm additional applications. Well-designed preclinical and clinical trials are still necessary to establish the safety and efficacy of wild Daucus carota for human use.

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Section: Discussionsupporting

confidence: 86%

Section: Phytochemistry and Bioactive Compounds/chemical Compositionmentioning

confidence: 99%

Section: Antibacterial Activitymentioning

confidence: 99%

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The Wild Carrot (Daucus carota): A Phytochemical and Pharmacological Review

Ismail,

Shebaby,

Daher

et al. 2023

Plants

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“…Randrianarivelo et al (2009) reported that oxygenated terpenes in general, particularly 1,8-cineole, linalool and α-terpineol, have an important role in the antibacterial activity of myrtle, while Carson and Riley (1995)insist the role of linalool. This information was confirmed by several studies (Hendry et al 2009;Silva et al 2012;Eduardo et al 2017).…”

supporting

confidence: 74%

Chemical composition and antimicrobial activity of Myrtus communis essential oils from Algeria

et al. 2021

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Abstract. Mohamadi Y, Lograda T, Ramdani M, Figueredo G, Chalard P. 2021. Chemical composition and antimicrobial activity of Myrtus communis essential oils from Algeria. Biodiversitas 22: 933-946. The objectives of this study were to determine the chemical composition and the antibacterial activities of Myrtus communis essential oils. The aerial parts of the myrtle were collected from nineteen localities of the Algerian coast, and subjected to hydrodistillation. The chemical composition of essential oils was analyzed using gas chromatography coupled with mass spectrometry (GC/MS). The antibacterial activity was evaluated by the disk diffusion method against ten bacterial species. Essential oils of M. communis was pale yellow oils, very fragrant, with an average yield of 0.68 ± 0.6%. Forty-six compounds were identified, representing an average of 99.17 ± 0.6% of total oils. The α-pinene was the most abundant component in the essential oils of all populations studied, with a mean of 50.1 ± 10.3%, followed by 1,8-cineole (22.27 ± 4.32%), limonene (5.16 ± 2.67%), linalool (3.79 ± 2.97%), α-terpineol (2.75 ± 1.12%), geranyl acetate (1.95 ± 0.7%) and methyl eugenol (1.40 ± 0.98%). Myrtenyl acetate was only observed in four populations with significant levels (from 10.66 to 20.94%). Six chemotypes have been identified in these oils. The α-pinene – 1,8-cineole - limonene chemotype was found in the majority of populations. The chemotype of α-pinene - 1,8-cineole - α-terphenyl acetate characterizes the Oued El-Aneb population. The α-pinene - neryl formate - limonene chemotype is observed in the Honaïn population. The remaining populations are characterized by myrtenyl acetate. The essential oils of M. communis were effective against Staphylococcus aureus ATCC 25923, Salmonella enterica ATCC35659, Proteus mirabilis, and Escherichia coli ATCC 25922; however, no significant effect was observed on Klebsiella pneumonia ATCC 700603 and Serratia liquefaciens.

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Development of Antiacne Nanogel containing Cinnamon Bark Oil (Cinnamomum burmannii Nees ex Bl.) and Olive Oil (Olea europaea L.)

Priani

Nurhasanah

Suparman

2022

RJPT

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Acne is the most common skin problem which can occur due to a bacterial infection. Cinnamon bark oil contains cinnamaldehyde and other active compounds which have antibacterial activity. Olive oil is also known to have antibacterial activity and can reduce skin irritation from cinnamon bark oil application. The nanogel system is known to be suitable for the delivery of active compounds to treat acne. This research aims to develop nanogel preparations containing cinnamon bark oil and olive oil and characterize the gels' physical properties and antibacterial activity against Propionibacterium acnes. The antibacterial activity test of cinnamon bark oil and preparations were carried out by the diffusion method using the perforation technique. Nanogels were prepared using tween 80 as a surfactant, PEG 400 as a co-surfactant, and Viscolam as a gelling agent. The nanogels were characterized by organoleptic, pH, viscosity, spreadability, percent transmittance, globule size diameter, and stability tests. The result showed that cinnamon bark oil has antibacterial activity against Propionibacterium acnes with a MIC value of 0.2%. Nanogel preparations containing cinnamon bark oil (2; 3; and 4%) and olive oil (2%) have good physical characteristics and stability with a clear appearance with an average globule size 129 ±17 nm; 132 ± 18 nm; and 135 ± 19 nm, respectively. Nanogel preparations have potent antibacterial activity against Propionibacterium acnes. The antibacterial activity of the gels depends on oil concentration.

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Antibacterial Potential Of The Alpha-pinene Positive Enantiomer Against The Strain <em>Proteus mirabilis</em>

Cited by 3 publications

References 5 publications

The Wild Carrot (Daucus carota): A Phytochemical and Pharmacological Review

The Wild Carrot (Daucus carota): A Phytochemical and Pharmacological Review

Chemical composition and antimicrobial activity of Myrtus communis essential oils from Algeria

Development of Antiacne Nanogel containing Cinnamon Bark Oil (Cinnamomum burmannii Nees ex Bl.) and Olive Oil (Olea europaea L.)

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