Antibacterial Potentials of Ve&lt;i&gt;rnonia amygdalina&lt;/i&gt; against Antibiotic-Resistant &lt;i&gt;Salmonella&lt;/i&gt; Specie Isolated from Nworie River, Imo State, Nigeria

Chikwendu, C. I.; Egbadon, Emmanuel; Okuma, Blessing

doi:10.18052/www.scipress.com/ilns.56.82

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…Whereas the insensitivity of Salmonella bacilli to aqueous extracts of C. papaya leaves has been reported [21,22]. Chikwendu et al [23] also concluded that aqueous extract of roots, stem and leaves of V. amygdalina has no anti-salmonolla effects.…”

Section: Discussionmentioning

confidence: 99%

Ethnobotanical Survey and Evaluation of Anti-Salmonella Potentials of Commonly Used Plants for Typhoid Treatment in Ogbomoso, Oyo State, Nigeria

Deborah

Awodugba

Adetutu

2021

JOCAMR

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This study assessed the sensitivity of S. typhi to extracts of commonly used plants in treatment of typhoid in Ogbomoso, Oyo State, Nigeria. Ethnobotanical survey was conducted using a structured questionnaire. Powdered leaves of plants were extracted by maceration in distilled water. In vitro sensitivity of S. typhi to the extracts were assessed using agar well diffusion method. Groups of rats were infected orally with 0.5 McFarland suspension of S. typhi. Bacteremia in the animals was monitored by plating on Salmonella-Shigellar agar. Biochemical parameters were determined spectrophotometrically. Histological analysis was performed using H&E staining method. S. typhi was sensitive only to P. guajava and A. indica leaf extracts. V. amygladina (90.31%) and C. papaya (92.26%) showed highest percentage inhibition of S. typhi comparable with ciprofloxacin (99.86%). Haematological parameters varied significantly (p<0.05) among the groups. Antioxidant status of rats, total protein, albumin and the corresponding globulin level increased significantly (p<0.05) in the groups treated with P. guajava and A. indica. C. papaya and C. citratus ameliorated the histopathological damages observed in the liver and intestine of S. typhi infected rats. The studied plants have direct activities against S. typhi, thus reflecting the reason for their combination in traditional system of medicine.

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Section: Discussionmentioning

confidence: 99%

Ethnobotanical Survey and Evaluation of Anti-Salmonella Potentials of Commonly Used Plants for Typhoid Treatment in Ogbomoso, Oyo State, Nigeria

Deborah

Awodugba

Adetutu

2021

JOCAMR

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“…Aqueous extracts of the leaf, stem and roots showed no activity against antibiotic resistant Salmonella isolate, while the ethanol and acetone extracts showed activity rates of 20% and 17% for roots, 14.3% and 12.9% for stem, and, 15.7% and 11.4% for leaf [44]. The anti-Salmonella activity has been further confirmed by the ethanolic extract [50,51].…”

Section: Vernonia Amygdalinamentioning

confidence: 99%

Herbal Medicines Used in the Treatment of Typhoid in the Ga East Municipality of Ghana

Bekoe

Agyare

Sarkodie

et al. 2017

IJTDH

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In Ghana, majority of the people patronize herbal medicines for the treatment of both chronic and acute ailments as well as infectious and non-infectious diseases. As such, the use of herbs as medicines in the treatment of enteric (typhoid) fever is very widespread. Aims: This study therefore investigates anti-typhoidal herbal medicinal formulations that are for sale on the Ghanaian market with regards to the contents on the product labels and assesses the various active plant components in the light of documented evidence of their use in the treatment of typhoid. Bekoe et al.; IJTDH, 23(4): 1-13, 2017; Article no.IJTDH.31448 2 Methodology: Herbal products for the treatment of typhoid were sampled from herbal medicine shops and pharmacies and assessed for the type of formulation, plant and non-plant constituents, dosage, indications, treatment duration and contraindications. Results: Majority of the products (87%, n=16) had registration numbers whilst 13% had none. These anti-typhoid formulations were simultaneously recommended for the treatment of malaria (56%) (9 out of 16 products), jaundice (31%), various types of pains (body pains, headache, menstrual pains) (8%), stress (8%) and fatigue (8%). All the preparations had more than one plant as its active constituent. Forty-four percent (44%) contained 2 plants species as the active ingredients, 37% contained between 3 to 5 plant species, 13% contained 6 to 10 plant species and 6% contained more than 10 plant species. The most frequently occurring active plant constituents of these products were Carica papaya L. (Caricaceae), Morinda lucida (Rubiaceae), Citrus aurantifolia (Rutaceae), Vernonia amygdalina (Compositae) and Azadirachta indica (Meliaceae). Conclusion: In all, thirty-four different plant species belonging to 25 families were found to be present in these products. A literature search on the plants species showed that their traditional use in the treatment of typhoid is well documented and hence their resulting formulations may as well be very effective. Original Research Article

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Antibacterial Potentials of Ve<i>rnonia amygdalina</i> against Antibiotic-Resistant <i>Salmonella</i> Specie Isolated from Nworie River, Imo State, Nigeria

Cited by 2 publications

References 14 publications

Ethnobotanical Survey and Evaluation of Anti-Salmonella Potentials of Commonly Used Plants for Typhoid Treatment in Ogbomoso, Oyo State, Nigeria

Ethnobotanical Survey and Evaluation of Anti-Salmonella Potentials of Commonly Used Plants for Typhoid Treatment in Ogbomoso, Oyo State, Nigeria

Herbal Medicines Used in the Treatment of Typhoid in the Ga East Municipality of Ghana

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