Antibacterial properties of a peroxidogenic strain of <i>Streptococcus mitior</i> (<i>mitis</i>)

LeBien, Tucker W.; Bromel, Mary

doi:10.1139/m75-015

Cited by 27 publications

(11 citation statements)

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“…The mechanisms of interference mediated by oral bacteria in this report are not clear, although many investigators have reported that viridans group streptococci produce substances with bacteriocin-like activity, including H 2 O 2 [7,11,[29][30][31]. In the accompanying article [32], we report the results of our investigation of the role of H 2 O 2 in preventing MRSA colonization of oral cavities in newborns.…”

Section: Discussionmentioning

confidence: 84%

Inhibition of Methicillin-Resistant Staphylococcus aureus Colonization of Oral Cavities in Newborns by Viridans Group Streptococci

Uehara¹,

Kikuchi²,

Nakamura³

et al. 2001

Clinical Infectious Diseases

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We investigated the role of viridans group streptococci in the prevention of colonization with methicillin-resistant Staphylococcus aureus (MRSA) in neonatal intensive care units. During a 26-month period at a children's hospital, 207 (49.9%) of 415 newborns were colonized with MRSA by the time of discharge. Two groups of newborns with matching durations of hospitalization were compared with regard to the prevalence of future colonization with MRSA: group 1 (103 patients) did not acquire colonization with viridans group streptococci and group 2 (63 patients) did acquire colonization with viridans group streptococci at birth or by 1 to 2 weeks (age, < or =11 days). The rate of colonization among patients in group 2 (9.5%) was significantly lower than that among patients in group 1 (44.7%; P<.001). No significant difference in patient characteristics (e.g., birth weight, diseases) was observed. These results indicate that viridans group streptococci, as bacteria that formerly occupied the oral cavities in newborns, may inhibit later colonization with MRSA.

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Section: Discussionmentioning

confidence: 84%

Inhibition of Methicillin-Resistant Staphylococcus aureus Colonization of Oral Cavities in Newborns by Viridans Group Streptococci

Uehara¹,

Kikuchi²,

Nakamura³

et al. 2001

Clinical Infectious Diseases

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“…Streptococci possess superoxide dismutase, and many strains are known to produce H # O # . There have been many studies on H # O # production by oral streptococci (Garcia-Mendoza et al, 1993 ;Holmberg & Hallander, 1973 ;LeBien & Bromel, 1975 ;Liebana et al, 1993 ;Willcox & Drucker, 1988), and this characteristic has often been important for the classification of these species (McLeod & Gordon, 1922 ;Whiley et al, 1990). However, there are few reports on H # O # production by S. pyogenes (Gibson et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

H2O2-nonproducing Streptococcus pyogenes strains: survival in stationary phase and virulence in chronic granulomatous disease

et al. 2001

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The production of hydrogen peroxide (H 2 O 2 ) and related phenotypes were studied with Streptococcus pyogenes strains isolated from cases of pharyngitis or severe group A streptococcal infections. Of the 46 strains examined (34 from severe infections and 12 from pharyngitis cases), 25 strains accumulated H 2 O 2 in the culture medium when grown under glucose-limited, aerobic conditions, whereas the rest of the strains did not. There was no correlation between these traits and the type of disease from which each strain had been isolated. The H 2 O 2 -nonproducing strains tested in this study belonged to T type 3 or T type 12. The accumulation of H 2 O 2 started when the culture reached the late exponential phase. A rapid loss of cell viability accompanied H 2 O 2 accumulation but was completely prevented by the addition of a catalase, indicating that the lethality was actually caused by H 2 O 2 . Cells of H 2 O 2 -nonproducing strains were resistant to killing by phagocytes from patients with chronic granulomatous disease (CGD), whereas those of H 2 O 2 -producing strains were subject to killing. Subcutaneous inoculation of 10 5 c.f.u. H 2 O 2 -nonproducing S. pyogenes strains into the hind footpads of CGD mice provoked more prominent swelling of the footpad than did H 2 O 2 -producing strains. The mortality rate in the CGD mice infected with the H 2 O 2 -nonproducing strains was higher than that produced by the H 2 O 2 -producing strains. It is suggested that H 2 O 2 -nonproducing S. pyogenes strains are prevalent in humans and that they may be a potential threat to the health of CGD patients.

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“…The inhibitory substances produced by our isolates have not been identified, but probably do not include hydrogen peroxide, since the strains were all grown anaerobically (LeBien and Bromel, 1975;Malke et al, 1974). Since L. mtrinus isolates produce large amounts of lactic acid , it would be reasonable to assume that this product accounts, at least in part, for inhibitory activities recorded with this species.…”

Section: Discussionmentioning

confidence: 97%

Antibiotic Resistance and Production of Inhibitory Substances among Bacterial Strains Isolated from the Oral Cavities of BALB/c Mice

St-Amand

Lavoie

1988

J Dent Res

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In the oral cavities of BALB/c mice, microbial population levels are regulated by multifactorial processes. Factors include the production of inhibitory substances and the exchange of genetic material. In this work, 371 isolates from different sites (saliva, tongue, teeth, and mucosa) of the oral cavities of BALB/c mice were screened for resistance to antibiotics and antimicrobial activity. Antibiotic-resistant strains represented 25% of the total flora. Among the predominant species, all the S. faecalis isolates showed multiresistance, and 23% of the Lactobacillus murinus isolates and 15% of the Staphylococcus aureus were resistant to at least one antibiotic. Resistance to aminoglycosides (neomycin, streptomycin, kanamycin, and gentamicin) was most frequently encountered. In S. faecalis, high levels of resistance were recorded to neomycin and streptomycin but not to gentamicin or kanamycin. Macrolides (M), lincosamides (L), streptogramin B (S), tetracycline (Tc), and chloramphenicol (Cm) resistance was also present in multiresistance patterns, especially among S. faecalis isolates. Hemolytic (Hly+) streptococci were less resistant to MLS, Tc, and Cm than were non-hemolytic (Hly-) isolates. Resistance to beta-lactam antibiotics was detected only among staphylococci and with a low prevalence (4%). The frequencies of strains producing antimicrobial substances against the indicator strains (S. mutans LG-1, S. sanguis Ny 101, and A. viscosus Ny 1) were high for L. murinus (76%) and S. faecalis (57% for Hly- and 90% for Hly+), but low for S. aureus (7%). These results indicate that the indigenous oral flora could interfere with colonization by allochthonous micro-organisms and that resistance patterns should be taken into account for the elimination of the oral indigenous flora by antibiotic treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

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Antibacterial properties of a peroxidogenic strain of Streptococcus mitior (mitis)

Abstract: An antibacterial substance produced by a strain of Streptococcus mitior, and isolated from a human throat culture, was found to inhibit the growth of streptococci and staphylococci. The substance was characterized as hydrogen peroxide.

Cited by 27 publications

References 0 publications

Inhibition of Methicillin-Resistant Staphylococcus aureus Colonization of Oral Cavities in Newborns by Viridans Group Streptococci

Inhibition of Methicillin-Resistant Staphylococcus aureus Colonization of Oral Cavities in Newborns by Viridans Group Streptococci

H2O2-nonproducing Streptococcus pyogenes strains: survival in stationary phase and virulence in chronic granulomatous disease

Antibiotic Resistance and Production of Inhibitory Substances among Bacterial Strains Isolated from the Oral Cavities of BALB/c Mice

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