Antibacterial Properties of Eucalyptus globulus Essential Oil against MRSA: A Systematic Review

Elangovan, Shakthi; Mudgil, Poonam

doi:10.3390/antibiotics12030474

Cited by 28 publications

(12 citation statements)

References 39 publications

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“…In this context, anti-bacterial activity of 1,8-Cineol was demonstrated against various strains of E. coli (including Avian Pathogenic E. coli ; APEC) isolated from broiler chicken [ 43 ]. However, further investigations concerning the anti-microbial activity revealed that the fruit oil of E. globulus was hardly active against multidrug-resistant (MDR) Gram-negative bacteria [ 44 , 45 ]. Acknowledged limitations of the clinical application of 1,8-Cineol are its instability, the short half-life and its vitality.…”

Section: Anti-microbial and Anti-viral Potentialmentioning

confidence: 99%

Modes of Action of 1,8-Cineol in Infections and Inflammation

et al. 2023

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The monoterpene 1,8-Cineol is a natural plant-based therapeutic agent that is commonly applied to treat different inflammatory diseases due to its mucolytic, anti-microbial and anti-inflammatory properties. It has become increasingly clear in the recent years that 1,8-Cineol spreads almost everywhere in the human body after its oral administration, from the gut to the blood to the brain. Its anti-microbial potential and even its anti-viral effects have been observed to include numerous bacteria and fungi species. Many recent studies help to better understand the cellular and molecular immunological consequences of 1,8-Cineol treatment in inflammatory diseases and further provide information concerning the mechanistic modes of action in the regulation of distinct inflammatory biosynthetic pathways. This review aims to present a holistic and understandable overview of the different aspects of 1,8-Cineol in infections and inflammation.

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Section: Anti-microbial and Anti-viral Potentialmentioning

confidence: 99%

Modes of Action of 1,8-Cineol in Infections and Inflammation

et al. 2023

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“…The sub-lethal dose was considered to be between 10 and 25 μg/mL, which resulted in survival rates of 52.2 and 36.2% in HepG2 cells. It was observed that Eucalyptol insignificantly inhibited cell growth up to a concentration of 25 μg/ml ( 54 ).…”

Section: Resultsmentioning

confidence: 99%

Production of natural flavor compounds using Bacillus subtilis-fermented soybean meal extract and their biological potential: a comprehensive in vitro study

Abd-Alrahman,

Ramadan,

Maraay

et al. 2024

Front. Nutr.

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This study aims to investigate the production of natural flavor compounds through the utilization of Bacillus subtilis-fermented soybean meal extract and evaluate their biological potential. The experiment involved a comprehensive in vitro investigation to assess the capabilities and effects of the produced flavor compounds. The resulting flavor compounds were subjected to various in vitro tests to assess their properties, including cytotoxicity, antioxidant activity, anticancer potential, antiviral activity, and antimicrobial activity. To enhance the fermentation process, soybean meal extract was fortified with a combination of L-Lysine and L-Threonine. Gas chromatography-mass spectrometry (GC/MS) analysis was conducted on the fermented soybean meal using two strains of Bacillus subtilis, namely NRCH123 and NRCZ144. This analysis revealed the presence of various volatile compounds in all extracts, including Butylated hydroxytoluene. The fermented soybean extract with bacillus subtilis NRCZ144 (B2) fortified with a combination of 2.5% (w/w) L-Lysine and 2.5% w/w L-threonine (SLT2) exhibited a rich profile of flavor compounds, with Eucalyptol being identified as the predominant compound. The antioxidant activity of the SLT2 extract was found to be 72.04% at a concentration of 100 μg/mL, indicating significant antioxidant potential. Furthermore, when tested against the human liver cancer cell line HepG2, the extract demonstrated anticancer activity with an IC50 value of 2.26 μg/mL. The extract exhibited potent cytotoxicity, with an IC50 value of 1.02 μg/mL. Importantly, the SLT2 extract displayed strong antibacterial and antifungal activity, even at very low concentrations. The extract’s antimicrobial properties indicate its potential for inhibiting the growth of bacteria and fungi.

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“…It still has to be acknowledged that the lack of statistical significance for motility at 120 h upon treatment with 1 mg/mL, potentially due to the statistical approach used and the sample size, does not imply a lack of biological relevance since, indeed, motility is almost completely suppressed. Nonetheless, literature shows a good amount of work that proves antibacterial activity of this EO, both alone and in combination with other agents, even against strains of methicillin-resistant Staphylococcus aureus (MRSA) bacteria, with MIC values ranging from 0.032 to 10 mg/mL 35 .…”

Section: Discussionmentioning

confidence: 99%

Short- and long-term effects of essential oils on swine spermatozoa during liquid phase refrigeration

Troisio,

Bertocchi,

Ventrella

et al. 2024

Sci Rep

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The application of essential oils as potential alternatives to antibiotics in swine semen storage is promising, due to their antioxidant and antibacterial properties. However, detrimental effects on spermatozoa should be clarified first. The aim of this study was to evaluate 9 essential oils (EOs; Satureja montana, Pelargonium graveolens, Cymbopogon nardus, Melaleuca leucadendron, Eucaliptus globulus, Citrus limon, Lavandula angustifolia, Lavandula hybrida, Mentha piperita) and a blend (GL mix) on key morpho-functional parameters of swine spermatozoa. Test compounds were firstly chemo-characterized and experimental doses were prepared by suspending a fixed number of spermatozoa with 3 different concentrations (0.1, 0.5, 1 mg/mL) of EOs. Experimental doses were stored at 16 °C and sampled after 3 and 120 h for analysis. Overall, S. montana, P. graveolens and L. angustifolia EOs induced the strongest alterations, with C. nardus and E. globulus EOs being the best tolerated. Swine spermatozoa represent a good preliminary testing platform to screen toxicity and its different patterns. The comprehensive overview on the potential mechanisms of action of some of the most common EOs, despite of the direct aim of the study being swine reproduction, may be exploited in other fields of research within both veterinary and human medicine.

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Antibacterial Properties of Eucalyptus globulus Essential Oil against MRSA: A Systematic Review

Cited by 28 publications

References 39 publications

Modes of Action of 1,8-Cineol in Infections and Inflammation

Modes of Action of 1,8-Cineol in Infections and Inflammation

Production of natural flavor compounds using Bacillus subtilis-fermented soybean meal extract and their biological potential: a comprehensive in vitro study

Short- and long-term effects of essential oils on swine spermatozoa during liquid phase refrigeration

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