Antibacterial Properties of Larval Secretions of the Blowfly, Lucilia sericata (Diptera: Calliphoridae)

Elshehaby, Mohamed; Tony, Mahran; Sultan, Abdel Rahman S.; Reheem, Abdel Baset M. A. Abd

doi:10.21608/eajbse.2017.14468

Cited by 1 publication

(2 citation statements)

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“…Therefore, focus on new strategies for the eradication of severe infections associated with biofilm is very important. The presence of small antibacterial agents (1 kDa) in E/S showed that against a range of bacteria including S. aureus is active (Elshehaby et al 2017). E/S enzymes can dissolve biofilms and inhibit biofilm growth (Elshehaby et al 2017;Harris et al 2009).…”

Section: Resultsmentioning

confidence: 99%

“…Regardless of the preference of the mode of action, larvae of L. sericata initiate their activities in the wound by chemical secretions and excretions (Nigam et al 2006;Sherman 2014). Maggot extractions and secretion (ES) treatment have been shown to aid the healing process by stimulates the regeneration of blood vessels and also has a proliferative effect on the growth of human endothelial cells (Elshehaby et al 2017). Many studies have shown evidence that larvae have antimicrobial activity in two ways, including antimicrobial action by ingestion larvae of wound bacteria, which are killed when they enter the larval 12 digestive tract also through the antimicrobial activity of secretions and larval excretions, including salivary gland secretions and fecal wastes (Valachova et al 2013).…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of maggot extractions and secretion (E/S) of Lucilia sericata in reducing wound surface in experimental scalding burn injury

et al. 2020

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Abstract. Amiri ZS, Akbarzadeh K, Douraghi M, Abdi KM, Afshar AA, Ghaffari J, Kordshouli RS, Akbari M, Rafinejad J. 2021. Effectiveness of maggot extractions and secretion (E/S) of Lucilia sericata in reducing wound surface in an experimental scalding burn injury. Nusantara Bioscience 13: 11-15. Lucilia sericata larvae have been successfully used as medicinal larvae for wound healing. This study was performed to evaluate the therapeutic effects of the primary ointment made from excretory-secretory substances of L.sericata larvae on experimental burn wounds on rabbits under laboratory conditions. Extraction of ES from the third stage of L.sericata larvae and antibiogram testing was done. Four rabbits were randomly divided into four groups; three standard third-grade burn wounds were created on the back of each rabbit for intervention groups (B, D) of wounds were used respectively from the original ointment made from ES and ES without accompanying material. Nitrofurazone ointment was used for the positive (C) and placebo ointment was used for the negative (A). On the 21st day, all scars of wounds in groups B and D were separated and the wound was free of infectious tissue, whereas in groups A and C that the scars were clinging to the base. The level of the ulcer was significantly lower in the E/S intervention group and the infectious tissue was not observed during the treatment of group B and D wounds. Methicillin-resistant Staphylococcus aureus (MRSA) did not show resistance to excretory-secretory substances of L. sericata larvae. The debridement and recovery process was faster in the ES-treated group and the initial ointment than in the control group. The results showed that maggot extractions and secretion (E/S) of L. sericata in reducing wound healing is appropriate for treatment.

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Section: Resultsmentioning

confidence: 99%