Antibacterial properties of main-chain cationic polymers prepared through amine–epoxy ‘Click’ polymerization

Abstract

Poly(β-hydroxyl amine)s are shown to be potent antibacterial materials.

Influence of PEG Subunit on the Biological Activity of Ionenes: Synthesis of Novel Polycations, Antimicrobial and Toxicity Studies

“…To date, many different SMAMPs such as polyacrylates, [15][16][17][18] polynorbornenes, [19][20][21][22] polycarbonates, [23,24] poly-𝛽-lactams (nylon-3), [25][26][27] poly(styrene-alt-maleic anhydride) derivatives, [28][29][30][31] and ionenes [6][7][8][32][33][34][35][36][37][38][39][40][41][42] (polycations containing cationic group inside the mainchain) have been synthesized and investigated as antimicrobial agents. Published data has revealed that a hydrophilic-lipophilic balance (HLB) is one of the most important factors determining selectivity toward microbes over red blood cells (RBCs) as highlighted in many reviews.…”

“…[45] Interestingly, many reported ionenes, of which HLB is moved strongly toward hydrophilicity, are highly active against bacteria and almost no hemolytic. [6][7][8]32,[34][35][36][37][38][39][40][41] Besides AMPs produced by microorganisms, there is a large group of AMPs called host-defense peptides (HDPs), which are an important element of the innate immune system of all multicellular organisms. [46] Interestingly, besides cationic and hydrophobic groups present in a majority of reported SMAMPs, HDPs contain additional neutral, hydrophilic moieties.…”

“…[ 45 ] Interestingly, many reported ionenes, of which HLB is moved strongly toward hydrophilicity, are highly active against bacteria and almost no hemolytic. [ 6–8,32,34–41 ]…”

Main-chain/side-chain type phosphine oxide-containing reactive polymers derived from the same monomer: controllable RAFT polymerisation and ring-opening polycondensation

“…The pH-response of CP3 was studied according to the literature method. 64 When CP3 was soaked in aqueous HCl, the structures of tertiary amines were protonated to give ammonium salts. The maximum water uptake was increased from 67% to 133% after the protonation of CP3 by HCl.…”

Crystallization, Mechanical, and Antimicrobial Properties of Diallyl Cyanuric Derivative-Grafted Polypropylene

“…The transmission of microorganisms could be minimized by introducing antimicrobial functions. Phenol derivatives, − metal particles or ions, − quaternary ammonium, − and N -halamine − compounds are currently used for the preparation of numerous types of biocidal materials. N -halamines are a promising candidate for the preparation of antibacterial materials due to their several advantages, including their broad-spectrum antibacterial activity, nontoxicity, durability, and low environmental impact. , N -halamine compounds contain one or more nitrogen–halogen covalent bonds, formed by the halogenation of imide, amide, or amine groups.…”