Antibacterial properties of nanoparticles

Hajipour, Mohammad Javad; Fromm, Katharina M.; Ashkarran, Ali Akbar; Aberasturi, Dorleta Jiménez de; Larramendi, Idoia Ruiz de; Rojo, Teófilo; Serpooshan, Vahid; Parak, Wolfgang J.; Mahmoudi, Morteza

doi:10.1016/j.tibtech.2012.06.004

Cited by 2,304 publications

(1,332 citation statements)

References 77 publications

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“…There are also theories regarding the mechanisms which inhibit the actions of silver on bacteria, such as: induction of oxygen free radicals or direct destruction of bacterial cell membranes by silver ions. Silver ions can interact with bacterial cell walls, bacterial capsule, cell membrane proteins, but also penetrate into the cytoplasm [28][29][30]. Silver ions block the activity of respiratory enzymes in bacterial cells, which prevents cellular respiration.…”

Section: Silver Complexes With Ty In the Supramolecular Cr Systemmentioning

confidence: 99%

Supramolecular Structures as Carrier Systems Enabling the Use of Metal Ions in Antibacterial Therapy

Natkaniec

Jagusiak

Rybarska

et al. 2017

Self-Assembled Molecules – New Kind of Protein Ligands

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The antimicrobial activity of metal ions, especially silver ions, has been known since ancient times. Consequently, finding an accessible, cheap and efficient carrier of metal ions remains an important challenge in molecular biology. The supramolecular system presented in this chapter consists of a mixture of Congo red and Titan yellow molecules forming a supramolecular ligand which is a potent complexing agent of silver ions. Delivery of ions in complex with supramolecular dye is advantageous due to the reduced toxicity. In addition, the use of Congo red provides selective action and -thanks to increased solubility -facilitates efficient dispersion of the carrier dye and excretion from the organism.

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Section: Silver Complexes With Ty In the Supramolecular Cr Systemmentioning

confidence: 99%

Supramolecular Structures as Carrier Systems Enabling the Use of Metal Ions in Antibacterial Therapy

Natkaniec

Jagusiak

Rybarska

et al. 2017

Self-Assembled Molecules – New Kind of Protein Ligands

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“…However, microbial resistance to these drugs has developed on a very large scale over time, greatly reducing their effectiveness, and is an ever growing problem (Hajipour et al 2012). One of the most promising strategies for overcoming microbial resistance is the use of nanoparticles.…”

Section: Discussionmentioning

confidence: 99%

Synergistic activity of doped zinc oxide nanoparticles with antibiotics: ciprofloxacin, ampicillin, fluconazole and amphotericin B against pathogenic microorganisms

Sharma

Jandaik

Kumar³

2016

An. Acad. Bras. Ciênc.

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Combination therapy of antibiotics and nanoparticles can be used against multi drug resistant microorganisms. Nanoparticles (NPs) have been reported to show antimicrobial activity. The antimicrobial activities of doped ZnO nanoparticles (ZnO NPs) were studied against fungi, gram-positive and gramnegative bacteria using the standard microdilution method. The interaction between the nanoparticle and the antibiotic was estimated by calculating the fractional inhibitory concentration (FIC index) of the combination through checkerboard assay. Experimental results demonstrated that 10% doped zinc oxide nanoparticles (ZnO NPs) exhibited the maximum antimicrobial effect in contrast with that of the 1% loading and pure ZnO nanoparticles. The enhancement in antimicrobial effect was seen when combined with antibiotic. Synergistic and additive effects were found. No antagonistic effect was found. More synergistic effect was observed when combined with ciprofloxacin than ampicillin. Fungus showed only additive effect. The results are quite in terms with MIC clearly depicting that high doping agent is most suitable for combined therapy. 100% synergistic interaction was observed in higher doping with both ciprofloxacin and ampicillin. This study provides a preliminary report of the synergistic activity of nanoparticles with antibiotics against different pathogenic strains. This provides groundwork for further studies on the combination therapy of nanoparticles with antibiotics.

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“…In many Gramnegative bacteria, QS is regulated by acyl-homoserine lactones (AHLs) that vary in the length of the alkyl side chain, or the presence of hydroxyl-or oxo-substituents. Disruption of bacterial QS either using specific inhibitors that compete with or enzymes that degrade AHLs, without exerting toxicity, is considered as a promising approach to circumvent bacterial drug-resistance and a route to the development of a new generation of medicines to deal with bacterial infections Particles produced from inorganic substances such as metals, or silica, ranging in size from a few nanometers to the micrometer length scale, have extensively been studied for their use in antibacterial control [24][25][26]. Also, particles comprising organic building blocks such as polymers, lipids, or proteins of a different type, have been used to prepare antibiotic-loaded formulations for controlled drug delivery [27][28][29].…”

Section: Introductionmentioning

confidence: 99%

An investigation of the interactions between an E. coli bacterial quorum sensing biosensor and chitosan-based nanocapsules

Qin

Engwer

Desai

et al. 2017

Colloids and Surfaces B: Biointerfaces

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Highlights Chitosan-coated nanocapsules, but not nanoemulsions, influence the -potential of E.coli  A fixed number of nanocapsules binds and promotes aggregation of bacteria  In silico simulations agree closely with experimental results  Chitosan-coated nanocapsules attenuate the bacterial quorum sensing response § These authors contributed equally to this publication * Author for correspondence Colloids and Surfaces B: Biointerfaces 149 (2017) 358-368 AbstractWe examined the interaction between chitosan-based nanocapsules (NC), with average hydrodynamic diameter ~114-155 nm, polydispersity ~0.127, and -potential ~+50 mV, and an E. coli bacterial quorum sensing reporter strain. Dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) allowed full characterization and assessment of the absolute concentration of NC per unit volume in suspension. By centrifugation, DLS, and NTA, we determined experimentally a "stoichiometric" ratio of ~80 NC/bacterium. By SEM it was possible to image the aggregation between NC and bacteria. Moreover, we developed a custom in silico platform to simulate the behavior of particles with diameters of 150 nm and -potential of +50 mV on the bacterial surface. We computed the detailed force interactions between NC-NC and NC-bacteria and found that a maximum number of 145 particles might interact at the bacterial surface. Additionally, we found that the "stoichiometric" ratio of NC and bacteria has a strong influence on the bacterial behavior and influences the quorum sensing response, particularly due to the aggregation driven by NC.

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Antibacterial properties of nanoparticles

Cited by 2,304 publications

References 77 publications

Supramolecular Structures as Carrier Systems Enabling the Use of Metal Ions in Antibacterial Therapy

Supramolecular Structures as Carrier Systems Enabling the Use of Metal Ions in Antibacterial Therapy

Synergistic activity of doped zinc oxide nanoparticles with antibiotics: ciprofloxacin, ampicillin, fluconazole and amphotericin B against pathogenic microorganisms

An investigation of the interactions between an E. coli bacterial quorum sensing biosensor and chitosan-based nanocapsules

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