Antibacterial Properties of Sol–Gel Biomaterials with Different Percentages of PEG or PCL

Catauro, Michelina; Tranquillo, Elisabetta; Poggetto, Giovanni Dal; Naviglio, Silvio; Barrino, Federico

doi:10.1002/masy.201900056

Cited by 14 publications

(11 citation statements)

References 20 publications

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“…The effect of surface morphology on cell orientation has also been studied, as well. Biomaterials with different percentages of PEG were also used as antimicrobial materials [ 43 ].…”

Section: Introductionmentioning

confidence: 99%

Cell Behavior of Primary Fibroblasts and Osteoblasts on Plasma-Treated Fluorinated Polymer Coated with Honeycomb Polystyrene

et al. 2021

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The development of new biocompatible polymer substrates is still of interest to many research teams. We aimed to combine a plasma treatment of fluorinated ethylene propylene (FEP) substrate with a technique of improved phase separation. Plasma exposure served for substrate activation and modification of surface properties, such as roughness, chemistry, and wettability. The treated FEP substrate was applied for the growth of a honeycomb-like pattern from polystyrene solution. The properties of the pattern strongly depended on the primary plasma exposure of the FEP substrate. The physico-chemical properties such as changes of the surface chemistry, wettability, and morphology of the prepared pattern were determined. The cell response of primary fibroblasts and osteoblasts was studied on a honeycomb pattern. The prepared honeycomb-like pattern from polystyrene showed an increase in cell viability and a positive effect on cell adhesion and proliferation for both primary fibroblasts and osteoblasts.

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“…The effect of surface morphology on cell orientation has also been studied, as well. Biomaterials with different percentages of PEG were also used as antimicrobial materials [ 43 ].…”

Section: Introductionmentioning

confidence: 99%

Cell Behavior of Primary Fibroblasts and Osteoblasts on Plasma-Treated Fluorinated Polymer Coated with Honeycomb Polystyrene

et al. 2021

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“…After the implant came into contact with blood, a complex protein adsorption layer was formed on the surface. Platelets adhered to the surface of the adsorption layer increased the viscosity and further aggregated to release a large number of coagulation factors to cause coagulation [31,32]. The number of platelets adhered to the PLGA drugloaded coating surface was the least, and the coating did not deform or cause further platelet aggregation.…”

Section: Blood Compatibility Analyses Of Plga Drug-loading Coatingsmentioning

confidence: 99%

PLGA Coatings and PLGA Drug-Loading Coatings for Cardiac Stent Samples: Degradation Characteristics and Blood Compatibility

Jia

Zhang

2021

Coatings

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PLGA (Poly lactic-co-glycolic acid) and PLGA drug-loading coatings were prepared on 316 L stainless steel by electrostatic spray deposition (ESD). The surface morphology, three-dimensional morphology, and crystal structures of the coatings were observed by scanning electron microscopy (SEM), atomic force microscopy (AFM), and X-ray diffraction (XRD). Thermal properties, molecular weight, and coating composition were studied by differential scanning calorimetry (DSC), gel permeation chromatography (GPC), and NMR. The degradation behaviors of the coatings were studied by mass changes, relative molecular mass and distributions, polymer compositions, thermal properties, and surface morphologies. The blood compatibilities of the coatings were investigated by platelet adhesion testing and dynamic coagulation times. SEM results indicated the drug-loading coating with 33% RAPA had the smoothest and most compact morphology. Addition of RAPA decreased the Tg of the PLGA coating, accompanied by partial crystallization that slowed the degradation rate of the drug-loaded coating. Microscopically, the morphology of the PLGA drug-loaded coating was coarser than the PLGA coating. The average surface roughness values of line and surface scannings were 16.232 nm and 39.538 nm, respectively. The surface of the drug-loading coating was micro uneven, and the macro smooth and micro multiphase separation structure helped improve its blood compatibility.

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“…Synthetic materials also possess the advantageous possibility of incorporating components with anti-inflammation and antibiotic effects to reduce the possibility of complications [7] or biological factors, such as bone morphogenic proteins (BMP-9), to achieve an osteoinductive effect [8].…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility Assessment of Two Commercial Bone Xenografts by In Vitro and In Vivo Methods

2022

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Bone substitutes based on xenografts have been used for a long time in bone regeneration thanks to their inductive capacity for bone tissue regeneration. Some bone-based scaffolds have been modified by adding collagen and other proteins to improve their regenerative capacity and prevent migration and aggregation, especially particles. However, rejection of this graft has been reported due to protein residues caused by poor material preparation. We compared the in vitro and in vivo biological response of two commercial xenografts (InterOss®, F1 and InterOss® Collagen, F2) and a commercial porcine collagen membrane (InterCollagen® Guide, F3) as a rapid degradation control. Fourier Transform Infrared Spectroscopy (FT-IR) analysis evidenced the presence of hydroxyl, orthophosphate, and carbonate groups of the xenografts and amide groups of collagen. Thermogravimetric analysis (TGA) of the xenografts demonstrated their thermal stability and the presence of a few amounts of organic material. The study by differential scanning calorimetry showed the presence of endothermic peaks typical of the dehydration of the xenografts (F1 and F2) and for the collagen membrane (F3), the beginning of structural three-dimensional protein changes. Subsequently, in vitro biocompatibility tests were carried out for the materials with Artemia salina and MTT cell viability with HeLa cells, demonstrating the high biocompatibility of the materials. Finally, in vivo biocompatibility was studied by implanting xenografts in biomodels (Wistar rats) at different periods (30, 60, and 90 days). The F1 xenograft (InterOss) remained remarkably stable throughout the experiment (90 days). F2 (InterOss Collagen) presented a separation of its apatite and collagen components at 60 days and advanced resorption at 90 days of implantation. Finally, the collagen membrane (F3) presented faster resorption since, at 90 days, only some tiny fragments of the material were evident. All the in vivo and in vitro test results demonstrated the biocompatibility of the xenografts, demonstrating the potential of these materials for tissue engineering.

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Antibacterial Properties of Sol–Gel Biomaterials with Different Percentages of PEG or PCL

Cited by 14 publications

References 20 publications

Cell Behavior of Primary Fibroblasts and Osteoblasts on Plasma-Treated Fluorinated Polymer Coated with Honeycomb Polystyrene

Cell Behavior of Primary Fibroblasts and Osteoblasts on Plasma-Treated Fluorinated Polymer Coated with Honeycomb Polystyrene

PLGA Coatings and PLGA Drug-Loading Coatings for Cardiac Stent Samples: Degradation Characteristics and Blood Compatibility

Biocompatibility Assessment of Two Commercial Bone Xenografts by In Vitro and In Vivo Methods

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