Antibacterial properties studies of trunk barks of terminalia ivorensis (Combretaceae), a commercial and medicinal specie, on some methicillin-resistant Staphylococci spp strains.

Abstract

Abstract:Background: Methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis and coagulase-negative Staphylococcus infections are a worldwide concern. Terminalia ivorensis, of Combretaceae family plant, is widely used traditional medicinal in Côte d'Ivoire to treat dermal diseases (affection in which Staphylococci are implied) including local inflammation and also to treat voice-loss. Objectives: This study focused to investigate the effect in vitro of the extracts of trunk barks of Terminalia ivorensis on some methicillin/oxacillin-resistant strains of Staphylococcus aureus, S. epidermidis, coagulase-negative S. and reference strain of S. aureus ATCC 25923. Methods: Antibacterial activity of aqueous, 70% ethanolic 70% and aqueous residue extracts was assessed using agar disc-diffusion method and liquid medium microdilution method in 96 multi-well micro-titer plates. This method led us to determine minimum inhibition concentration (M.I.C.) and minimum bactericidal concentration (M.B.C.). The presence of chemical groups major was detected qualitatively. Results: Aqueous and 70% ethanolic 70% extracts showed significant activity against all the bacteria except aqueous residue when compared with the standard antibiotic oxacillin (5µg/ml). M.I.C. for aqueous and 70% ethanolic 70% extracts ranged from 0,83-16,67 mg/ml and 0,156-13,33 mg/ml respectively. Viable cell determination revealed the bactericidal nature of the two barks extracts. The 70% ethanolic 70% extract exhibited the highest activity according to the M.B.C. values. The phytochemical analysis indicates the presence of tannins, saponins, flavonoids, terpen/sterols, coumarins, polyphenols and traces of alkaloid. Conclusion:The in-vitro antibacterial efficacy shown by the barks of this plant and his lushness in chimical compounds, would justify use of this one in the traditional treatment of some diseases of microbial origin. These compounds could be suggested to provide alternative solution to the development of new therapeutic agents.

Ethnoecological knowledge of ticks and treatment of tick-borne diseases among Maasai people in Northern Tanzania

“…Other Terminalia spp. and members of the Combretaceae family have been found to have anti-bacterial [ 42 ] and anti-trypanosomal compounds [ 43 ], suggesting that these plants could be of importance in modern pharmacology.…”

“…The efficacy of treatments for ECF and sweating sickness were said to depend on the stage of the disease. Often, traditional treatments are viewed as just as effective as modern medicine [ 51 ] and indeed laboratory experiments have confirmed the efficacy of certain plant families against bacteria and protozoans in vitro [ 42 ].…”

A review on medicinal plant extracts and their active ingredients against methicillin-resistant and methicillin-sensitive Staphylococcus aureus

“…Falodun et al suggested that the Persea americana plant is effective on both fungi and bacteria (81). The petroleum ether extract of the plant has an excellent antibacterial activity against MRSA with an IC50 value of 7.8 μg/mL (82).…”

Effect of Provenance Variations on the Growth and Development of Terminalia ivorensis (A Chev)

“…Terminalia ivorensis also plays a major role in increasing soil fertility where fall off leaves are decomposed and add more nutrients to the soil [2]. This species is widely used for medicinal purposes in Africa [3,4]. This tree species if protected from logger can attain heights of up to 50 m and girth of 500 cm.…”