Antibacterial property, corrosion and discoloration resistance of pure copper containing Zn or Ni

Jiang, Yun; Zhang, Wenjing; Mi, Xujun; Huang, Guojie; Xie, Haofeng; Feng, Xue; Peng, Lijun; Yang, Zhen

doi:10.1007/s12598-022-02098-8

Cited by 8 publications

(1 citation statement)

References 30 publications

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“…Most human diseases originate from infections by various microbial bacteria. − The representative drug of the organic class dominates the treatment of bacterial diseases, − but there is antibiotic resistance during treatment process. − Organic drugs such as penicillin, artemisinin, − aspirin, , and valium have been widely used in the treatment of various diseases. The functional group , and conformational relationships of organic drugs play a key role for development of these drugs.…”

Section: Introductionmentioning

confidence: 99%

Changing Cinnamaldehyde Skeleton Achieves Antibacterial Nanoswitch

Zhao,

Miao,

et al. 2024

ACS Appl. Mater. Interfaces

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Changeable substituent groups of organic molecules can provide an opportunity to clarify the antibacterial mechanism of organic molecules by tuning the electron cloud density of their skeleton. However, understanding the antibacterial mechanism of organic molecules is challenging. Herein, we reported a molecular view strategy for clarifying the antibacterial switch mechanism by tuning electron cloud density of cinnamaldehyde molecule skeleton. The cinnamaldehyde and its derivatives were self-assembled into nanosheets with excellent water solubility, respectively. The experimental results show that α-bromocinnamaldehyde (BCA) nanosheets exhibits unprecedented antibacterial activity, but there is no antibacterial activity for αmethylcinnamaldehyde nanosheets. Therefore, the BCA nanosheets and αmethylcinnamaldehyde nanosheets achieve an antibacterial switch. Theoretical calculations further confirmed that the electron-withdrawing substituent of the bromine atom leads to a lower electron cloud density of the aldehyde group than that of the electron-donor substituent of the methyl group at the α-position of the cinnamaldehyde skeleton, which is a key point in elucidating the antimicrobial switch mechanism. The excellent biocompatibility of BCA nanosheets was confirmed by CCK-8. The mouse wound infection model, H&E staining, and the crawling ability of drosophila larvae show that as-prepared BCA nanosheets are safe and promising for wound healing. This study provides a new strategy for the synthesis of low-cost organic nanomaterials with good biocompatibility. It is expected to expand the application of natural organic small molecule materials in antimicrobial agents.

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