Antibacterial, remineralising and matrix metalloproteinase inhibiting scandium-doped phosphate glasses for treatment of dental caries

Valappil, Sabeel P.; Neel, Ensanya A. Abou; Pickup, David M.; Burden, E. H. W. J.; Sahdev, Rohan; Miles, Emma J.; Cooper, Lee; Ansari, Tahera; Hanna, John V.; Higham, Susan

doi:10.1016/j.dental.2021.10.014

Cited by 5 publications

(1 citation statement)

References 54 publications

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“…On the other hand, there are many kinds of active sites on the surface of Sc 2 O 3 -MgO, such as lattice limited hydroxyl, free hydroxyl, and ion holes, which can be used as adsorption and surface reaction centers and cause mechanical damage. Scandium (Sc 3+ ) has been shown to have the ability to inhibit the growth of Klebsiella pneumoniae, E. coli, and Pseudomonas aeruginosa [40][41][42]. The purpose of doping Sc 3+ in the nano-MgO lattice is to increase the lattice defects and then increase the ROS content produced during the antibacterial process to enhance the antibacterial property of MgO.…”

Section: Antibacterial Activity Of Nanofibersmentioning

confidence: 99%

Preparation and Properties of (Sc2O3-MgO)/Pcl/Pvp Electrospun Nanofiber Membranes for the Inhibition of Escherichia coli Infections

Liu

et al. 2023

IJMS

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Due to their high porosity, large specific surface area, and structural similarity with the extracellular matrix (ECM), electrospun nanofiber membranes are often endowed with the antibacterial properties for biomedical applications. The purpose of this study was to synthesize nano-structured Sc2O3-MgO by doping Sc3+, calcining at 600 °C, and then loading it onto the PCL/PVP substrates with electrospinning technology with the aim of developing new efficient antibacterial nanofiber membranes for tissue engineering. A scanning electron microscope (SEM) and energy dispersive X-ray spectrometer (EDS) were used to study the morphology of all formulations and analyze the types and contents of the elements, and an X-ray diffraction (XRD), thermogravimetric analysis (TGA), and Fourier transform attenuated total reflection infrared spectroscopy (ATR-FTIR) were used for further analysis. The experimental results showed that the PCL/PVP (SMCV-2.0) nanofibers loaded with 2.0 wt% Sc2O3-MgO were smooth and homogeneous with an average diameter of 252.6 nm; the antibacterial test indicated that a low load concentration of 2.0 wt% Sc2O3-MgO in PCL/PVP (SMCV-2.0) showed a 100% antibacterial rate against Escherichia coli (E. coli).

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Section: Antibacterial Activity Of Nanofibersmentioning

confidence: 99%