Antibacterial resistance: an emerging ‘zoonosis’?

Abstract

Antibacterial resistance is a worldwide threat, and concerns have arisen about the involvement of animal commensal and pathogenic bacteria in the maintenance and spread of resistance genes. However, beyond the facts related to the occurrence of resistant microorganisms in food, food-producing animals and companion animals and their transmission to humans, it is important to consider the vast environmental 'resistome', the selective pathways underlying the emergence of antibacterial resistance and how we can prepare answers for tomorrow.

Breaking the Spell: Combating Multidrug Resistant ‘Superbugs’

“…Unfortunately, unrestrained use of antibacterial past 50 years has wielded selection pressure on susceptible bacteria stains, which attributed to the endurance of drug resistance ( Levy and Marshall, 2004 ; Tacconelli, 2009 ), among them some are resistant to more than one antibiotic. Presently, the treatment of these infections has once again becomes increasingly complicated as microorganisms are becoming resistance to the available antimicrobial options ( Pitout and Laupland, 2008 ; Nordmann et al, 2011 ; Khan and Nordmann, 2012a ; Labro and Bryskier, 2014 ). With course of time, sustained selective pressure by various antibiotics has culminated into organisms augmenting ancillary resistance mechanisms that led to multidrug resistance (MDR)—novel penicillin-binding proteins (PBPs), enzyme dependant drug alteration, altered membrane permeability, mutated drug targets and increased efflux pump expression.…”

Mechanisms of antibiotic resistance to enrofloxacin in uropathogenic Escherichia coli in dog

“…This is due to the use of high amounts of antibiotics in all fields of zootechnical industry [1][2][3][4][5].…”

Highly Tigecycline-Resistant Klebsiella pneumoniae Sequence Type 11 (ST11) and ST147 Isolates from Companion Animals

“…irculation of resistant bacteria among animals is a concern for public health, since animals can act as reservoirs, facilitating the maintenance, evolution, and spread of such bacteria (1,2). The emergence of carbapenem-resistant bacteria has dramatically hindered therapeutic options (3).…”