Antibacterial screening of some Peruvian medicinal plants used in Callería District

Klouček, Pavel; Polesny, Zbynek; Svobodová, Blanka; Vlková, Eva; Kokoška, Ladislav

doi:10.1016/j.jep.2005.01.062

Cited by 140 publications

(92 citation statements)

References 26 publications

(24 reference statements)

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“…Phytochemical research based on ethnopharmacological informations is generally considered an effective approach to the discovery of antinfective agents from higher plants (Kloucek et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Modern pharmacopoeias contain at least 25% of drugs derived from plants and many others which are synthetic analogues build on prototype compounds isolated from plants (De Silva, 2005). Phytochemical research based on ethno pharmacological information is generally considered an effective approach in the discovery of new antiinfective agents from higher plants (Kloucek et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial activity of ethanolic extract of Acalypha wilkesianaleaves growing in Jos, Plateau State, Nigeria

Goptep¹,

Agada²,

Gbise³

et al. 2010

MJM

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Antibacterial activity of ethanolic extract of Acalypha wilkesiana leaves growing in Vom, Jos, Plateau state, Nigeria was carried out to verify claims by the locals of its medicinal properties. We tested the extract for activity against Staphylococcus aureus (G+), Yersinia enterocolitica, Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa and Klebsiella aerogenes (G-). The extract exhibited activity against the organisms in varying degrees. In the agar diffusion test, Y. enterocolitica showed the highest zone of inhibition (18 mm) at the highest concentration of extract tested (20 mg/mL) while E. coli, S. aureus, S. typhi, P. aeruginosa and K. aerogenes showed zones of inhibition of 17, 16, 15, 14 and 16 mm respectively. At extract concentration of 2.5 mg/mL, Y. enterocolitica and P. aeruginosa did not show any zones of inhibition while E.coli, S. aureus, S. typhi, and K. aerogenes showed zones of inhibition of 7, 6, 6 and 7 mm respectively. Below extract concentration of 2.5 mg/mL, there was no zone of inhibition observed with any organism. The MIC of the extract against the organisms was 5 mg/mL except on S. aureus where the MIC was 2.5 mg/mL. The MBC of the extract was 10 mg/mL against Y. enterocolitica, S. typhi, P. aeruginosa and K. aerogenes, 5 mg/mL against E. coli and S. aureus. Preliminary phytochemical testing revealed the presence of tannins, steroids, flavonoids and cardiac glycosides while saponins, alkaloids and anthraquinones were not present. The result gives scientific backing to the use of the leaves by the local people in the treatment of conditions usually associated with the organisms tested.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of ethanolic extract of Acalypha wilkesianaleaves growing in Jos, Plateau State, Nigeria

Goptep¹,

Agada²,

Gbise³

et al. 2010

MJM

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show abstract

“…Possui também ação analgésica e sedativa, mas seu principal uso terapêutico é para os tratamentos de artrite e osteoartrite [49][50][51][52][53][54][55] .…”

Section: Unha-de-gato (Uncaria Tomentosa)unclassified

Interações medicamentosas associadas a fitoterápicos fornecidos pelo Sistema Único de Saúde

Felten

Magnus

Santos

et al. 2015

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<p class="MsoNormal" style="text-align: justify; line-height: 150%;">Devido a variadas comprovações científicas relatando os benefícios de plantas medicinais, tem se observado um aumento na utilização da fitoterapia no tratamento de várias doenças. O Brasil ganha destaque nesse campo possuindo um terço da flora mundial. Os fitoterápicos possuem compostos químicos responsáveis pelos seus variados efeitos. Entretanto, muitas dessas substâncias ativas ainda não têm suas atividades farmacológicas bem descritas ou conhecidas. Os conhecimentos científicos gerados a partir de ensaios clínicos randomizados e a descrição de casos clínicos têm apontado a relação de efeitos adversos, toxicidade e contraindicações relacionadas ao uso concomitante de fitoterápicos e medicamentos alopáticos, ainda que o medicamento fitoterápico seja considerado de baixa toxicidade. Diretrizes brasileiras do Ministério da Saúde determinaram prioridades na investigação de plantas medicinais e implantaram a fitoterapia na prática de atenção básica. Portanto, o objetivo deste estudo foi realizar um levantamento na literatura científica sobre as interações decorrentes do uso de medicamentos associados aos fitoterápicos do Sistema Único de Saúde e, com isso, auxiliar na divulgação dos dados existentes, fortalecendo o conhecimento de profissionais da área da saúde sobre os efeitos medicinais e tóxicos das plantas e, consequentemente colaborar com a implementação das práticas de fitoterapia.</p>

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“…Although many of its compounds are chemically known, the properties of most of these compounds remain unknown. Some pharmacological activities of P. amarus have already been confirmed by scientific studies, such as: (1) treatment for hepatitis B, by suppression of the replication of the virus (Thyagarajan et al, 1988), (2) hepatoprotective effect against actions of paracetamol, carbon tetrachloride (CCl4), galactosamine and alcohol (Krithika et al, 2009, Pramyothin et al, 2007) -phyllanthin and hypophyllanthin, which are lignans present in P. amarus, are described as having hepatocyte-protective action against carbon tetrachloride (Khatoon et al, 2006), (3) aqueous extracts from P. amarus have shown a strong inhibitory action against hepatic carcinoma (Rajeshkumar & Kuttan, 2000), (4) possible antispasmodic effects of the extract on the smooth musculature have been reported because they contribute to the effects on the renal calculi (Kassuya et al, 2003), (5) antibacterial activity of the ethanolic extract (Kloucek et al, 2005), (6) potential anti-inflammatory activity of both the hexane extract and the chemical fraction rich in lignans, obtained from the leaves of P. amarus. The anti-inflammatory activity of lignans was evaluated and it was noticed that nirantin is the most active substance of this fraction.…”

Section: Phyllanthus Amarus Lmentioning

confidence: 99%

The Use of Brazilian Medicinal Plants to Combat Schistosoma mansoni

Allegretti¹,

Oliveira²,

Oliveira³

et al. 2012

Schistosomiasis

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Antibacterial screening of some Peruvian medicinal plants used in Callería District

Cited by 140 publications

References 26 publications

Antibacterial activity of ethanolic extract of Acalypha wilkesianaleaves growing in Jos, Plateau State, Nigeria

Antibacterial activity of ethanolic extract of Acalypha wilkesianaleaves growing in Jos, Plateau State, Nigeria

Interações medicamentosas associadas a fitoterápicos fornecidos pelo Sistema Único de Saúde

The Use of Brazilian Medicinal Plants to Combat Schistosoma mansoni

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