Antibacterial therapy in general medical wards

Lawson, D. H.; MacDonald, Sarah

doi:10.1136/pgmj.53.620.306

Cited by 13 publications

(6 citation statements)

References 12 publications

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“…22,23 Symptomscommonlyincludenausea, vomiting,andanorexia.Diarrhea,glossitis, and stomatitis are much less frequent. Hepatotoxicity, a known but rare complication of sulfonamide Folate synthesis pathway and sites of action of trimethoprim and sulfamethoxazole.…”

Section: Gastrointestinalmentioning

confidence: 99%

“…Gastrointestinal intolerance occurs in approximately3%to8%ofpatients. 22,23 Symptomscommonlyincludenausea, vomiting,andanorexia.Diarrhea,glossitis, and stomatitis are much less frequent. Hepatotoxicity, a known but rare complication of sulfonamide treatment, seems uncommon with trimethoprim-sulfamethoxazoletreatment, and the risk is considered comparabletootherantimicrobialagents.…”

Section: Gastrointestinalmentioning

confidence: 99%

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Trimethoprim-Sulfamethoxazole Revisited

Masters¹,

O’Bryan²,

Zurlo³

et al. 2003

Arch Intern Med

313

225

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During the past 3 decades, the combination of trimethoprim and sulfamethoxazole has occupied a central role in the treatment of various commonly encountered infections and has also been particularly useful for several specific clinical conditions. However, changing resistance patterns and the introduction of newer broad-spectrum antibiotics have led to the need to carefully redefine the appropriate use of this agent in clinical practice. While trimethoprim-sulfamethoxazole's traditional role as empirical therapy for several infections has been modified by increasing resistance, it remains a highly useful alternative to the new generation of expanded-spectrum agents if resistance patterns and other clinical variables are carefully considered. It also seems to have an increasing role as a cost-effective pathogen-directed therapy with the potential to decrease or delay development of resistance to newer antibiotics used for empirical treatment. In addition, trimethoprim-sulfamethoxazole continues to be the drug of choice for several clinical indications.

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Section: Gastrointestinalmentioning

confidence: 99%

Section: Gastrointestinalmentioning

confidence: 99%

Trimethoprim-Sulfamethoxazole Revisited

Masters¹,

O’Bryan²,

Zurlo³

et al. 2003

Arch Intern Med

313

225

View full text Add to dashboard Cite

show abstract

“…The drugs most likely to be associated with adverse effects were warfarin, frusemide, digoxin and intravenous fluids. Of the commonly used antibacterial agents, both ampicillin and cotrimoxazole were associated with relatively high frequencies of usually mild reactions (Lawson & Macdonald, 1977).…”

Section: Discussionmentioning

confidence: 99%

Drug Surveillance for Adverse Drug Effects a Study of Medical Inpatients

Lawson

Jick

1978

J Clin Pharm Ther

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“…Surveillance of resistance grew out of such studies as those carried out by Finland and his colleagues at the Boston City Hospital (Kislak et al, 1964;McGowan and Finland, 1974a;Wallmark and Finland, 1961), followed up by specific surveys of antibiotic usage and resistance in many parts of the world (Kayser, 1978;Lawson and MacDonald, 1977;Moss et al, 1981;Mouton et al, 1976;Sheckler and Bennett, 1970;Swindell et al, 1983). O'Brien and his colleagues reported specifically international comparisons (O'Brien et al, 1978).…”

Section: Surveillance Of Antibiotic Usage and Resistancementioning

confidence: 99%

Antibiotic Policies—A Historical Perspective

Phillips¹

2005

Antibiotic Policies

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In 1945, at the end of World War II, Professor Sir Alexander Fleming (as he had then become) was asked by Butterworth, the medical publishers, to write a book on penicillin. He refused, on the grounds that he was too busy and that as a laboratory worker, he would have been unable to place penicillin therapy in a proper perspective in relation to other forms of medical and surgical treatment. However, he did agree to edit a book-and produced a volume (Fleming, 1946a) which is now something of a rarity-bringing together contributions from many of those who had gained experience of the compound during its early years of scarcity. Furthermore, he wrote an introductory chapter in which he overcame his modesty and set out some general rules for penicillin treatment (Fleming, 1946b). First, he wrote, it should be used only for the treatment of those infections caused by penicillin-sensitive microbes. His list of these runs: staphylococci, Streptococcus pyogenes, Streptococcus viridans, some anaerobic streptococci, pneumococcus, gonococcus, meningococcus, and so on. He also points out the importance of acquired resistance even though there was little of it at the time. However, despite the many casualties on this list, the principle remains sound. Second, the antibiotic must be given by an appropriate route, in adequate dosage, for an appropriate period of time-and despite uncertainties, the principles again remain true. En passant,

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Antibacterial therapy in general medical wards

Cited by 13 publications

References 12 publications

Trimethoprim-Sulfamethoxazole Revisited

Trimethoprim-Sulfamethoxazole Revisited

Drug Surveillance for Adverse Drug Effects a Study of Medical Inpatients

Antibiotic Policies—A Historical Perspective

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