Antibacterial therapy in the treatment of ascites peritonitis in liver cirrhosis

Abstract

Ascites-peritonitis is a severe complication in patients with decompensated cirrhosis. The effectiveness of treatment of ascites of peritonitis depends largely on its early diagnosis. The main component of the treatment of ascites-peritonitis - a complex and targeted antibiotic therapy. Third-generation cephalosporins are recommended as empirical antibiotic therapy. The article presents the results of treatment of ascites peritonitis depending on the method of administration of antibacterial drug - cefbactam. The drug was administered in three ways: intravenous, endolymphatic and combined. The results of pharmacokinetics of the drug depending on the method of administration, as well as the results of the effectiveness of the antibacterial effect in the compared groups of patients. (For citation: Ivanusa SY, Onnitsev IE, Khokhlov AV, et al. Antibacterial therapy in the treatment of ascites peritonitis in liver cirrhosis. Reviews on Clinical Pharmacology and Drug Therapy. 2018;16(2):49-56. doi: 10.17816/RCF16249-56).