Antibacterial treatment of bacterial vaginosis: current and emerging therapies

Ménard, Jean-Pierre

doi:10.2147/ijwh.s23814

Cited by 86 publications

(85 citation statements)

References 88 publications

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“…Tinidazole, an antimicrobial agent initially used for Trichomonas vaginalis infections has also been shown to be effective for bacteria vaginosis. Available data suggest that tinidazole has a role in special populations particularly for refractory or relapsing bacteria vaginosis [16,17]. In our study, cefpodoxime, cefixime and ciprofloxacin were also used in remarkable number of cases of infectious vaginitis.…”

Section: Discussionmentioning

confidence: 73%

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Assessment of Risk Factors and Medication Use for Infectious Vaginitis Among Females of Reproductive Age Visiting Maternity Hospital of Pokhara, Nepal

Dahal¹,

Jhendi²,

Pun³

et al. 2017

TOPHJ

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Background:Vaginitis is one of the most common gynecological problems in females especially in their reproductive ages and poses significant clinical consequences if left untreated. The study aims to assess the risk factors and medication used for its management in reproductive-aged females with vaginitis visiting maternity hospital of Pokhara, Nepal. Methods and Materials:A prospective cross-sectional study was carried out on females of age group 15-49 years, diagnosed with infectious vaginitis for the period of two months. Assessment was made based on clinical profile, questionnaire and personnel interview. Descriptive statistics was used for analyzing the results of the study. Results:A total of 130 patients were enrolled in the study. Most patients were literate, married and from rural area. Bacterial and fungal infections were common cause for vaginitis representing 56% and 22% respectively. The study shows that the 70% females with infectious vaginitis had a practice of using plain cloth napkins, during their menstruation period and 35% had previous infection in reproductive organ, also risk factors such as pregnancy, use of oral contraceptive, recent antibiotics/steroid use, sexually transmitted disease (STD) and diabetes were commonly present in females with infectious vaginitis. The most frequently (75%) prescribed drug was topical antibacterial -antifungal agents. Metronidazole, cefpodoxime and ciprofloxacin were mostly prescribed among antibiotics whereas fluconazole and clotrimazole were among antifungals. Conclusion:The study recommends need of awareness and educational programs concerning reproductive health and hygiene for females in these areas. Prescribing trend shows slight discrepancy from standard treatment guidelines for vaginal infections.

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Section: Discussionmentioning

confidence: 73%

“…Metronidazole is used to treat bacterial as well as trichomoniasis infection of the vagina [4]. Until now Metronidazole and clindamycin are regarded as the mainstay of therapy in the treatment of bacterial vaginosis [16]. Recently tinidazole is also used as an alternative.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Risk Factors and Medication Use for Infectious Vaginitis Among Females of Reproductive Age Visiting Maternity Hospital of Pokhara, Nepal

Dahal¹,

Jhendi²,

Pun³

et al. 2017

TOPHJ

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“…In a multicenter randomized control trial of 112 women with recurrent BV, suppressive therapy with twice weekly 0.75% metronidazole gel for 6 months after initial treatment achieved a significant reduction in symptomatic recurrence compared with placebo. 13 A recent meta-analysis demonstrated that hormonal contraceptive use may also be protective against BV. 11 Data on probiotics containing Lactobacillus show mixed results, with insufficient evidence for or against recommending probiotics for the treatment of BV.…”

Section: Recurrencementioning

confidence: 99%

Update on Vaginitis

Krapf¹

2014

Postgraduate Obstetrics & Gynecology

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Vaginitis refers to a broad range of conditions caused by infection, inflammation, or changes in the normal vaginal flora. In the absence of inflammation, the term vaginosis may be used. Symptoms of vaginal discharge, pruritus, irritation, and odor are common, with women often relying on selfdiagnosis and over-the-counter agents for relief. In a random sample of 2000 women throughout the United States contacted by telephone, 7.5% of white women and 18.1% of African American women reported an episode of vaginal symptoms in the previous year. Only 55% of white women and 83% of African American women who reported vaginal symptoms in the study consulted a health care professional for treatment.Most women purchased an over-the-counter antifungal preparation to treat their symptoms, whether or not they consulted a health care provider.

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“…Both harbor good efficacy against protozoal and anaerobic infection (1,2). Drugs are available in oral, vaginal, topical, intravenous preparation (5).…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis for Searching Efficacy of Tinidazole and Metronidazole

Zafar¹,

Bukhari²,

Noor³

et al. 2017

Ulutas Med J

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Background: The 5-nitroimidazole antimicrobial agents are considered as the treatment of choice for managing the amebic, protozoal and anerobic infections since 1969. With the advancement in medical field certain preference of drugs in this group were given. Tinidazole is now considered as a better one as compared to metronidazole because of specific pharmacokinetic & pharmacodynamics properties.Objectives: To assess the frequency of preferred using tinidazole as compared to metronidazole for managing the amebic, protozoal infections and anerobic infections Methodology: This is a descriptive study with simple random sampling. Total 32 published studies in 04 decades were included in the study i.e 1978 -2017. The National and Internationally published data was gathered by using electronic measures and via certain search engines i.e pubmed researches, medscape, Pak medinet.com, google search, Euraopean, Canadian, Australlian, Centre for Disease Control (CDC), and World Health Organization (WHO) published guidelines. The published guidelines, original and review articles were taken for reference. Case reports, editorials & short communications were excluded.Results: This Meta-analysis review of various published researches showed that out of 69.2%(n=09) out of total 13 studies are in favour of preferring tinidazole. The frequency preference of metronidazole is 23% (n=23). Only one study (7%) showed the efficacy of both drugs is same.Conclusion: Tinidazole is a better option to manage anaerobic, amebic and protozoal infections.

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Antibacterial treatment of bacterial vaginosis: current and emerging therapies

Cited by 86 publications

References 88 publications

Assessment of Risk Factors and Medication Use for Infectious Vaginitis Among Females of Reproductive Age Visiting Maternity Hospital of Pokhara, Nepal

Assessment of Risk Factors and Medication Use for Infectious Vaginitis Among Females of Reproductive Age Visiting Maternity Hospital of Pokhara, Nepal

Update on Vaginitis

Meta-analysis for Searching Efficacy of Tinidazole and Metronidazole

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