Antibacterial Triterpenoids Isolated from Lantana camara

Abstract

The known triterpenoids lantic acid, camaric acid, camarinic acid and lantanilic acid were isolated from Lantana camara (L.) cultivated in Egypt. The antibacterial activity of lantic acid was carried out using bioautography assays for Gram-positive and Gramnegative bacteria. Lantic acid was found to possess strong antibacterial activity against Escherichia coli and Bacillus cereus, in which 0.08 and 0.1 g were the minimum inhibition doses, respectively, compared to 0.05 and 0.005 g for chloramphenicol, respectively. The results indicate that lantic acid has broad spectrum antibacterial activity and may hold potential as a non-selective antimicrobial agent.

Genus Lantana: chemical aspects and biological activities

“…The antibacterial activity of lantic acid (57) isolated from L. camara leaves was studied in Grampositive and Gram-negative bacteria using bioautography assays (Saleh et al, 1999). Lantic acid was found to possess strong antibacterial activity against E. coli and Bacillus cereus, in which 0.08 and 0.1 µg were the minimum inhibitory doses, respectively, compared to 0.05 and 0.005 µg for chloramphenicol, respectively.…”

“…camara (roots) Pan et al (1993b) hederagenin (20), 25-hydroxy-3-oxoolean-12-en-28-oic acid (21) Singh et al (1996) 21,22β-epoxy-3β-hydroxyolean-12-en-28-oic methyl ester (22) Misra & Laatsch (2000) camarin (23), lantanone (24) L. camara (leaves) Begum et al (2006Begum et al ( , 2008b 22β-tigloyloxylantanolic acid (25) camarilic acid (26) L. camara (aerial parts) Begum et al (1995) L. camara (roots) Misra & Laatsch (2000) 19α-hydroxy ursolic (42), lantaiursolic acid (43) Pan et al (1993b) ursonic acid (44) L. camara (aerial parts) Begum et al (1995) lantacin (45) Begum et al (2006Begum et al ( , 2008b Singh et al (1990) 24-hydroxy-3-oxours-12-en-28-oic acid (48) L. trifolia (leaves) Rwangabo et al (1988) 3,24-dioxo-urs-12-en-28-oic acid (49) L. camara (leaves) Yadav & Tripathi (2003) α-amyrin (50) L. camara (leaves, flowers and stems) Ahmed et al (1972a;1972b) methyl 3-oxours-late (51) L. camara (leaves) Barua et al (1969) methyl-24-hydroxy-3-oxoursolate (52) L. indica (aerial parts) Singh et al (1989a) camaranoic acid (53) L. camara (aerial parts) Begum et al (2008a) lantoic acid (54) Begum et al (2008b); Roy & Barua (1985) camarinic acid (55) L. camara (leaves, 1 stems 2 ) Siddiqui et al (1995) 1 ; Barre et al (1997) 1 ; Saleh et al (1999) …”

“…camara (leaves) lantic acid (57) Barua et al (1969); Saleh et al (1999) camaracinic acid (58) L. camara (aerial parts) Begum et al (1995) methyl ursoxylate (59) Hart et al (1976aHart et al ( , 1976b 1,2…”

1H and 13C NMR reassignment of some chemical shifts of lantanilic acid and camaric acid

“…Years after this work, more studies have been conducted on 1 and 2, and they refer to Siddiqui's article for spectral assignments. [6][7][8][9][10][11][12][13][14][15][16] However, our analysis indicated that eight signals were wrongly assigned.…”

Topical Treatment of Dermatophytic Lesion on Mice (Mus musculus) Model

“…Test extract was obtained from L. camara which is a notorious and poisonous weed [25] imposing serious threat to native vegetation and biodiversity [26]. Though L. camara has been screened for its antimicrobial activities [27][28][29] but work with dermatophytes has not been done as yet. It is the first study which evaluates in vitro as well as in vivo (mice model) antidermatophytic potency of L. camara.…”