Antibacterial wound dressing from chitosan/polyethylene oxide nanofibers mats embedded with silver nanoparticles

Wang, Xiaoli; Cheng, Feng; Gao, Jing; Wang, Lu

doi:10.1177/0885328214554665

Cited by 68 publications

(40 citation statements)

References 22 publications

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“…In this sense, thermoplastic materials are the best choice as they can be easily prepared with different morphologies and complex forms for the required application by extrusion, molding, injection or dissolution, among other methods. In particular, nanofiber mats of thermoplastics are receiving a special attention due to their potential use as materials for drug delivery [1], wound dressings [2][3][4], tissue engineering [5,6], etc. Probably the most extended method to prepare this kind of mats is electrospinning, a process in which a polymer ejected solution is subjected to an electric field which deforms it to generate nanofibers [7].…”

Section: Introductionmentioning

confidence: 99%

PVDF/TiO2 nanocomposites prepared by solution blow spinning: Surface properties and their relation with S. Mutans adhesion

et al. 2017

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Thermoplastic nanocomposite materials with potential bactericide properties were prepared and their surface properties and adhesion to Streptococcus mutans, S. mutans, were characterized. Solution blow spinning was successfully used to prepare films with a fiber-like structure on the surface of nanocomposites based on Polyvinylidene fluoride, PVDF, filled with well dispersed TiO 2 nanoparticles. PVDF/TiO 2 nanocomposites were prepared varying the nanoparticles content (0 %, 1 %, 2 %, 5 % and 10 % by weight). In order to understand the influence of the presence of TiO 2 nanoparticles and the final surface properties on the adhesion of S. mutans to the materials, a deep characterization was carried out focusing on the morphology, roughness, surface free energy from contact angle measurements and cell adhesion by single cell force spectroscopy. It was observed that the uniform dispersion of the nanofiller arose from nanoparticles embedded in the polymer when fibers were created during the blow spinning process. TiO 2 content influenced the topography of the films probably due to a direct effect on the solvent evaporation rate. Although this factor greatly conditioned the roughness of the samples and therefore the surface free energy, S. mutant adhesion on the substrates under study was concluded to be more dependent on the specific interactions with the surface polar groups of the material.

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Section: Introductionmentioning

confidence: 99%

PVDF/TiO2 nanocomposites prepared by solution blow spinning: Surface properties and their relation with S. Mutans adhesion

et al. 2017

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“…Figure shows the antibacterial activities of FCS‐50 containing various amounts of ibuprofen, which were examined against Gram‐positive SA and Gram‐negative EC in terms of inhibition zone. Pure CS displays antibacterial activity and low cytotoxicity according to several reports . For this reason, drug‐loaded FCS‐50 also has a significant inhibitory activity against specific strains in open wounds or burns.…”

Section: Resultsmentioning

confidence: 95%

Preparation, characterization, antibacterial properties, and hemostatic evaluation of ibuprofen‐loaded chitosan/gelatin composite films

Cheng

Shu-zhen

et al. 2017

J of Applied Polymer Sci

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Ibuprofen-loaded chitosan/gelatin (CS/GE) composite films were fabricated in this work. The morphology of the composite film was investigated using scanning electron microscopy. The functional groups of the composite film before and after crosslinking were characterized using Fourier transform infrared spectroscopy. Meanwhile, the mechanical properties, antibacterial performance, cytocompatibility, and hemostatic activity of the composite films were investigated. The results show that the amount of CS affected the mechanical properties and liquid uptake capacities of the composite films. The composite film showed better bactericidal activity against Staphylococcus aureus than Escherichia coli. In vitro drug-release evaluations showed that crosslinking could control the drug-release rate and period in wound healing. Both types of CS/GE and drug-loaded CS/GE composite films also showed excellent cytocompatibility in cytotoxicity assays. The hemostatic evaluation indicated that the composite film crosslinked by glutaraldehyde in rabbit livers had a dramatic hemostatic efficacy. Therefore, ibuprofen-loaded CS/GE composite films are potentially applicable as a wound dressing material.

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“…Considering the antimicrobial agents, the silver has been an excellent broad spectrum antimicrobial agent effective against wide range of bacteria, viruses and fungal species (Kawashita et al 2003, Cui et al 2014, Haas et al 2015, Wang et al 2015, Hong et al 2017. It can show both bacteriostatic and bactericidal properties and was recently reported effective against cancer cells as well (Hazarika et al 2016, Mansour et al 2018.…”

Section: Introductionmentioning

confidence: 99%

Polyacrylonitrile nanofiber mats containing titania/AgNP composite nanoparticles for antibacterial applications

Jatoi

Mamun

2020

Mater. Res. Express

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Here in we present our research on electrospun polyacrylonitrile nanofiber films embedded with titania/AgNP nanoparticles for sustained antibacterial applications. Although silver possesses excellent antimicrobial characteristics and have been extensively exploited in applications where protection from microbial species and bacterial colonization is needed. Recently, it was discovered that silver may be allergic to skin and may induce detrimental side-effects such as argyria and argyrosis. Excess utilization of silver may even cause carcinoma. In continuation of our research on preparation of biologically safe antibacterial materials producing longer timed protection, here we proposed electrospun polyacrylonitrile nanofiber mats containing titania/AgNP composite nanoparticles. The titania/AgNP nanoparticles were prepared using polydopamine hydrochloride (pdopa) as adhesive and reducing agent. The nanoparticles were then added into polyacrylonitrile polymer solution and electrospun to fabricate polyacrylonitrile/titania/AgNP composite nanofiber mats (PTAgNP). The samples were characterized with XRD, TEM, SEM, FT-IR, SEM-EDX and antibacterial assays. Synthesis of the titania/AgNP was confirmed by XRD, TEM and EDX analysis. The nanofibers were studied with SEM, XRD, TEM and antibacterial tests. The SEM observations confirmed regular morphology of the nanofibers. The XRD and TEM analysis evidenced titania/AgNP contents in the polyacrylonitrile nanofibers. The antibacterial assays demonstrated excellent bacterial growth inhibition on agar plates and in the liquid medium. The samples were observed to inhibit growth of E. coli and S. aureus bacteria for up to 120 h. The quantitative bactericidal assay (relative cell viability, %) demonstrated 0% bacteria cell viability by polyacrylonitrile nanofibers containing 10 wt% of titania/AgNP nanoparticles.

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Antibacterial wound dressing from chitosan/polyethylene oxide nanofibers mats embedded with silver nanoparticles

Cited by 68 publications

References 22 publications

PVDF/TiO2 nanocomposites prepared by solution blow spinning: Surface properties and their relation with S. Mutans adhesion

PVDF/TiO2 nanocomposites prepared by solution blow spinning: Surface properties and their relation with S. Mutans adhesion

Preparation, characterization, antibacterial properties, and hemostatic evaluation of ibuprofen‐loaded chitosan/gelatin composite films

Polyacrylonitrile nanofiber mats containing titania/AgNP composite nanoparticles for antibacterial applications

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