Antibiofilm activity of the essential oil of citronella (Cymbopogon nardus) and its major component, geraniol, on the bacterial biofilms of Staphylococcus aureus

Pontes, Eveline Kelle Ursulino; Melo, Hider Machado; Nogueira, José Walter Araújo; Firmino, Nairley Cardoso Sá; Carvalho, Mário Geraldo de; Júnior, Francisco Eduardo Aragão Catunda; Cavalcante, Theodora Thays Arruda

doi:10.1007/s10068-018-0502-2

Cited by 47 publications

(32 citation statements)

References 18 publications

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“…C. nardus is particularly known for its antioxidant, anti-inflammatory, and antimicrobial properties [21][22][23]. The purpose of this work was to determine the chemical composition, chemotype and to analyse the anti-radical and anti-proliferative activity of the EO of C. nardus, used in Burkina Faso (West Africa), for the potential treatment of inflammatory and oxidative diseases.…”

Section: Introductionmentioning

confidence: 99%

Chemical composition, antioxidant, anti-inflammatory and antiproliferative activities of the essential oil of Cymbopogon nardus, a plant used in traditional medicine

Bayala

Coulibaly

Djigma

et al. 2020

Biomolecular Concepts

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AbstractObjectivesNatural products commonly used in traditional medicine, such as essential oils (EOs), are attractive sources for the development of molecules with anti-proliferative activities for future treatment of human cancers, e.g., prostate and cervical cancer. In this study, the chemical composition of the EO from Cymbopogon nardus was characterized, as well as its antioxidativeproperties and anti-inflammatory and antiproliferative activities on LNCaP cells derived from prostate cancer.MethodsThe chemical composition of the EO was determined by GC/FID and GC/MS analyses. The antioxidative properties were assessed using DPPH radical scavenging assay and ABTS+• radical cation decolorization assay, and the anti-inflammatory capacity was determined by the inhibition of the lipoxygenase activity. Antiproliferative activity was evaluated by MTT assay.ResultsCollectively, our data show that the major constituents of C. nardus EO are citronellal (33.06 %), geraniol (28.40 %), nerol (10.94 %), elemol (5.25 %) and delta-elemene (4.09 %). C. nardus EO shows modest antioxidant and anti-inflammatory activity compared to the standard galic acid. C. nardus EO exhibits the best antiproliferative activity on the prostate cancer cell line LNCaP with an IC50 of 58.0 ± 7.9 μg/mL, acting through the induction of the cell cycle arrest.ConclusionsThis study has determined that C. nardus EO efficiently triggers cytotoxicity and pens a new field of investigation regarding the putative use of this EO in vivo.

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Section: Introductionmentioning

confidence: 99%

Chemical composition, antioxidant, anti-inflammatory and antiproliferative activities of the essential oil of Cymbopogon nardus, a plant used in traditional medicine

Bayala

Coulibaly

Djigma

et al. 2020

Biomolecular Concepts

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“…The MICs of ε-PL (Shin Seung Hichem Co., Ltd., Seoul, Korea, 50% purity, food grade) were detected using a two-fold dilution method and TSB in 96-well polystyrene microtiter plates (SPL, Gyeonggi-do, Korea) [ 20 ]. ε-PL was diluted at double concentrations from 1.95 μg/mL to 8 mg/mL, and 50 μL of each concentration was mixed with 50 μL of bacterial culture adjusted to 1 × 10 5 CFU/mL in the 96-well plates.…”

Section: Methodsmentioning

confidence: 99%

Antimicrobial and Antibiofilm Effect of ε-Polylysine against Salmonella Enteritidis, Listeria monocytogenes, and Escherichia coli in Tryptic Soy Broth and Chicken Juice

Lee

Park

et al. 2021

Foods

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ε-Polylysine (ε-PL) is a safe food additive that is used in the food industry globally. This study evaluated the antimicrobial and antibiofilm activity of antibacterial peptides (ε-PL) against food poisoning pathogens detected in chicken (Salmonella Enteritidis, Listeria monocytogenes, and Escherichia coli). The results showed that minimum inhibitory concentrations (MICs) ranged between 0.031–1.0 mg/mL, although most bacterial groups (75%) showed MICs of 1.0 mg/mL. The reduction in the cell viability of pathogens due to ε-PL depended on the time and concentration, and 1/2 × MIC of ε-PL killed 99.99% of pathogens after 10 h of incubation. To confirm biofilm inhibition and degradation effects, crystal violet assay and confocal laser scanning microscopy (CLSM) were used. The biofilm formation rates of four bacterial groups (Salmonella, Listeria, E. coli, and multi-species bacteria) were 10.36%, 9.10%, 17.44%, and 21.37% at 1/2 × MIC of ε-PL, respectively. Additionally, when observed under a CLSM, ε-PL was found to induce biofilm destruction and bacterial cytotoxicity. These results demonstrated that ε-PL has the potential to be used as an antibiotic and antibiofilm material for chicken meat processing.

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“…Bacterial biofilms are also characteristic of the growth of one type of bacteria, i.e. a biofilm of Staphylococcus aureus [1]. Biofilms may form on living or nonliving surfaces and can be founded in natural, industrial, and hospital conditions.…”

Section: Biofilm Dental Biofilmmentioning

confidence: 99%

“…Marián Maďar 1 *, Jana Kačírová 1 , Eva Styková 1 , Michaela Maďarová 2 and Radomíra Nemcová 1 1 University of Veterinary Medicine and Pharmacy, Košice, Slovakia 2 Institute of Animal Physiology, Center of Biosciences, Slovak Academy of Sciences, Košice, Slovakia *Address all correspondence to: madarmarian@gmail.com of view, it is not yet possible to give direct recommendations for the use of probiotics. However, the available scientific evidence indicates that probiotic therapy is a promising approach also in the field of stomatology.…”

Section: Author Detailsmentioning

confidence: 99%

Methods for Searching of Potential Beneficial Bacteria and Their Products in Dental Biofilm

Maďar¹,

Kačírová²,

Styková³

et al. 2020

Bacterial Biofilms

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Dental microbiota is associated with different types of organisms with dentition including humans and is responsible for many oral diseases all over the world. Bacteria in a dental biofilm are important also in other diseases, i.e., endocarditis, pulmonary fibrosis, and arthritis, and some findings predict the connection of dental microbiota with cancerogenesis. Not all oral bacterial representatives are pathogenic or potentially pathogenic. Dental biofilm consists of numerous different bacteria that may have beneficial characteristics for good condition of dental and oral health. Searching for bacteria or their products with the beneficial effect is important in the development of new biologically based strategies for the prevention or treatment of oral and dental diseases. For searching of potential probiotic candidates are useful methods that could map phenotypic or genotypic characteristics of studied bacteria. This chapter is focused on the spectrum of these basic methods searching for beneficial bacteria and their products.

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Antibiofilm activity of the essential oil of citronella (Cymbopogon nardus) and its major component, geraniol, on the bacterial biofilms of Staphylococcus aureus

Cited by 47 publications

References 18 publications

Chemical composition, antioxidant, anti-inflammatory and antiproliferative activities of the essential oil of Cymbopogon nardus, a plant used in traditional medicine

Chemical composition, antioxidant, anti-inflammatory and antiproliferative activities of the essential oil of Cymbopogon nardus, a plant used in traditional medicine

Antimicrobial and Antibiofilm Effect of ε-Polylysine against Salmonella Enteritidis, Listeria monocytogenes, and Escherichia coli in Tryptic Soy Broth and Chicken Juice

Methods for Searching of Potential Beneficial Bacteria and Their Products in Dental Biofilm

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