Antibiofilm Effects of Novel Compounds in Otitis Media Treatment: Systematic Review
Ana Jotic,
Katarina Savic Vujovic,
Andja Cirkovic
et al.
Abstract:Otitis media (OM) is a frequent disease with incidence rate of 5300 cases per 100,000 people. Recent studies showed that polymicrobial biofilm formation represents a significant pathogenic mechanism in recurrent and chronic forms of OM. Biofilm enables bacteria to resist antibiotics that would typically be recommended in guidelines, contributing to the ineffectiveness of current antimicrobial strategies. Given the challenges of successfully treating bacterial biofilms, there is an growing interest in identifyi… Show more
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