Antibiofouling amphiphilic polymer-coated superparamagnetic iron oxide nanoparticles: synthesis, characterization, and use in cancer imaging in vivo

Park, Jinho; Yu, Mi; Jeong, Yong Yeon; Kim, Jin Woong; Lee, Kwangyeol; Phan, Vu Ngoc; Jon, Sangyong

doi:10.1039/b902445j

Cited by 83 publications

(67 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increasing the molecular weight or density of PEG chains causes a decrease in protein adsorption [55]. PEGylated nanoparticles show a lower cell uptake rate by macrophages (polymorphonuclear cells), resulting in an increase in the blood circulation time [31,33,36].…”

Section: Review Articlementioning

confidence: 99%

“…In addition, a single liposome can encapsulate several IONPs within its hydrophobic layer. Park et al [33] studied the stabilization of IONPs using amphiphilic copolymers, including a triblock copolymer (Pluronic F127, BASF), a commercially available PEG functionalized with a phospholipid moiety (DSGPE-mPEG 2000, Avanti Polar) and a random terpolymer containing dodecyl methacrylate, PEG methacrylate, and methacrylic acid. These three different approaches yielded very stable inorganic/ organic IONPs with sizes below 30 nm.…”

Section: Stabilization Of Ionps Using Polymer Chainsmentioning

confidence: 99%

See 1 more Smart Citation

The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications

et al. 2010

View full text Add to dashboard Cite

Iron-oxide nanoparticles (IONPs) represent a significant class of inorganic nanomaterial that is contributing to the current revolution in nanomedicine [1][2]. Their unique physical properties, including high surface area to volume ratios and superparamagnetism, confer useful attributes for medical applications such as magnetic resonance imaging (MRI), drug and gene delivery, tissue engineering and bioseparation [3].Two distinct classes of superparamagnetic IONP-based materials are currently used for medical applications: superparamagnetic iron-oxide (SPIO) nanoparticles with a mean particle diameter of 50-100 nm, and ultra-small superparamagnetic iron-oxide (USPIO) nanoparticles with a size below 50 nm. Th ese two classes of IONPs have been studied widely for medical applications, particularly as the next (potential) generation of MRI contrast agents. Th ey are also seen as potential vectors for drug and gene delivery. Th e biodistribution of these nanoparticles can be altered by the application of an external magnetic fi eld; they also have potential applications in hyperthermia therapy as some magnetic particles can heat up under the infl uence of a localized high-frequency magnetic fi eld.Th e intent of this review is to present recent advances in the synthesis of IONPs and their subsequent stabilization in biological fluids using polymers, focusing on the current strategies used to graft polymers onto IONPs surfaces (see Figure 1) and the diff erent types of polymers used. Th e additional properties conferred by the polymers, such as targeting, eff ects on biodistribution and pharmacokinetics, are also discussed, and the main applications of IONPs are reviewed. Synthesis and properties of iron-oxide nanoparticlesSPIO and USPIO nanoparticles are the most extensively studied magnetic nanoparticles for biomedical applications as they are both biocompatible and easy to synthesize. Both are composed of ferrite nanocrystallites of magnetite (Fe 3 O 4 ) or maghemite (Fe 2 O 3 , γ). Over the last ten years, there has been an explosion of interest in these materials and this has been reflected in a large number of recent publications describing the synthesis and modifi cation of hybrid IONPs. In this review, we focus on the polymer modifi cation of the nanoparticles, and provide only minimal information on the inorganic synthesis of IONPs. For more detailed information on IONP synthesis, readers are referred to other reviews [3,4]. The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applicationsCyrille Boyer 1 * , Michael R. Whittaker 1 , Volga Bulmus 2 , Jingquan Liu 1 and Thomas P. Davis 1 * University of New South Wales, AustraliaOver the past decade, the synthesis of superparamagnetic nanoparticles, especially iron-oxide nanoparticles (IONPs), has been researched intensively for many high-technology applications, including enhanced storage media, biosensing and medical applications. In medicine, IONPs are used as contrast agents in magnetic resonance imaging and in hyperthermia...

show abstract

Section: Review Articlementioning

confidence: 99%

Section: Stabilization Of Ionps Using Polymer Chainsmentioning

confidence: 99%

The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications

et al. 2010

View full text Add to dashboard Cite

show abstract

“…IONPs have become popular options for potential multifunctional drug delivery vehicles for several reasons. First, the chemistry of the surface modification for these nanoparticles is well known, and thus molecules such as targeting ligands and drugs can be conveniently tethered to their surface [12,[15][16][17][18]. Secondly, they have been extensively used as MRI contrast agents due to their superparamagnetic property [6,16].…”

Section: Introductionmentioning

confidence: 99%

“…There are vital reasons to modify the surface chemistry for MNPs so they can serve as successful drug delivery vehicles [18,[21][22][23]. First, these MNPs must be well dispersed in plasma for a reasonable period without aggregation which otherwise might cause severe embolization in vivo by blocking of capillary vessels.…”

Section: Introductionmentioning

confidence: 99%

“…In order to be able to achieve dispersibility in an aqueous medium, the best surface modification for these NPs is coating them with an amphiphilic polymer system [18,24]. The amphiphilic polymer will provide the hydrophobic part which can anchor to the magnetite NPs surface while the hydrophilic portion is directed towards the aqueous environment, thus providing robust water dispersibility.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chemotherapy of Prostate Cancer by Targeted Nanoparticles Trackable by Magnetic Resonance Imaging

Abdalla

Turner

Yates

2012

ISRN Nanotechnology

View full text Add to dashboard Cite

Prostate cancer (CaP) is the commonest diagnosed malignancy and the second main cause of cancer mortality in males in the United States. Thus, there is an urgent need to develop novel drug delivery systems to improve the chemotherapy option for CaP patients. The goal of this paper is to describe novel moleculary guided nanoscale drug delivery system with dual functionality for treatment and MR imaging of CaP. We describe the synthesis of iron oxide nanoparticles (IONPs) which are then coated with carboxyl-ended amphiphilic polymer. We present the protocol for tethering of the CaP targeting protein, human amino terminal fragment (hATF) to the terminal carboxyls of the IONPs. We describe the drug loading and release and the methods for measuring of the internalization of the hATF-guided IONPs into CaP cells. We also describe the methods for usages of IONPs are MR imaging contrast agent and successful targeted drug carriers.

show abstract

Dendritic‐Polymer‐Based Nanomaterials for Cancer Diagnosis and Therapy

Zhu

Gong²,

Gu³

et al. 2017

Nanobiomaterials

View full text Add to dashboard Cite

Antibiofouling amphiphilic polymer-coated superparamagnetic iron oxide nanoparticles: synthesis, characterization, and use in cancer imaging in vivo

Cited by 83 publications

References 27 publications

The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications

The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications

Chemotherapy of Prostate Cancer by Targeted Nanoparticles Trackable by Magnetic Resonance Imaging

Dendritic‐Polymer‐Based Nanomaterials for Cancer Diagnosis and Therapy

Contact Info

Product

Resources

About