Antibiofouling Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as Potential Magnetic Resonance Contrast Agents for in Vivo Cancer Imaging

Lee, Haerim; Lee, Eun‐Hye; Kim, Do Kyung; Jang, Nam Kyu; Jeong, Yong Yeon; Jon, Sangyong

doi:10.1021/ja061529k

Cited by 575 publications

(436 citation statements)

References 54 publications

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“…Even before the term 'nanotechnology' was popular, iron oxide particles were used to magnetically isolate and purify proteins, DNA, viruses and even whole mammalian cells. Numerous reports showed iron oxide nanoparticles potential application in medical diagnostics, 36 drug and gene targeting, 37,38 separation technologies, 39 biosensors 40 and hyperthermia. 41,42 More recently, iron oxide nanoparticles have been proved to possess an intrinsic enzyme mimetic activity similar to that found in natural peroxidases.…”

Section: Discussionmentioning

confidence: 99%

Nanoparticle delivery of anti-metastatic NM23-H1 gene improves chemotherapy in a mouse tumor model

Xiang

Zhang

et al. 2008

Cancer Gene Ther

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Gene therapy provides a promising approach for cancer treatment. Earlier studies suggested that poly-L-lysine-modified iron oxide nanoparticles (IONP-PLL) might be a promising gene delivery system that can transfect DNA efficiently in vitro and in vivo. In this study we used IONP-PLL as gene carriers to deliver the NM23-H1 gene, the first suppressor gene of cancer metastasis, to tumor cells in vivo. The intravenous injection of IONP-PLL carrying NM23-H1-GFP plasmid DNA significantly extended the survival time of an experimental pulmonary metastasis mouse model. In the IONP-PLL/NM23-H1-GFP-treated group, metastasis was clearly suppressed compared with the group treated with free NM23-H1-GFP plasmid. Furthermore, this gene therapy combined with cyclophosphamide treatment resulted in longer survival times and greater suppression of metastasis growth. In conclusion, treatment with IONP-PLL nanoparticles incorporating the NM23-H1gene is an efficient gene therapy method, and it is even more effective in combination with chemotherapy. This approach appears to be a promising strategy for treatment of metastatic tumors.

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Section: Discussionmentioning

confidence: 99%

Nanoparticle delivery of anti-metastatic NM23-H1 gene improves chemotherapy in a mouse tumor model

Xiang

Zhang

et al. 2008

Cancer Gene Ther

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“…The introduction of several attachment points on a single chain can reduce the packing density. Using this multi-interaction approach, many different types of functionalities have been used, such as dopamine [29], carboxylic acid [30] and trimethyl silane [31], yielding stable nanoparticles. Th e acid groups, not used for IONP stabilization, were exploited for the attachment of Cy5.5 dye [11] and small-molecule drugs such as doxorubicin [32].…”

Section: Stabilization Of Ionps Using Polymer Chainsmentioning

confidence: 99%

“…Increasing the molecular weight or density of PEG chains causes a decrease in protein adsorption [55]. PEGylated nanoparticles show a lower cell uptake rate by macrophages (polymorphonuclear cells), resulting in an increase in the blood circulation time [31,33,36].…”

Section: Review Articlementioning

confidence: 99%

The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications

et al. 2010

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Iron-oxide nanoparticles (IONPs) represent a significant class of inorganic nanomaterial that is contributing to the current revolution in nanomedicine [1][2]. Their unique physical properties, including high surface area to volume ratios and superparamagnetism, confer useful attributes for medical applications such as magnetic resonance imaging (MRI), drug and gene delivery, tissue engineering and bioseparation [3].Two distinct classes of superparamagnetic IONP-based materials are currently used for medical applications: superparamagnetic iron-oxide (SPIO) nanoparticles with a mean particle diameter of 50-100 nm, and ultra-small superparamagnetic iron-oxide (USPIO) nanoparticles with a size below 50 nm. Th ese two classes of IONPs have been studied widely for medical applications, particularly as the next (potential) generation of MRI contrast agents. Th ey are also seen as potential vectors for drug and gene delivery. Th e biodistribution of these nanoparticles can be altered by the application of an external magnetic fi eld; they also have potential applications in hyperthermia therapy as some magnetic particles can heat up under the infl uence of a localized high-frequency magnetic fi eld.Th e intent of this review is to present recent advances in the synthesis of IONPs and their subsequent stabilization in biological fluids using polymers, focusing on the current strategies used to graft polymers onto IONPs surfaces (see Figure 1) and the diff erent types of polymers used. Th e additional properties conferred by the polymers, such as targeting, eff ects on biodistribution and pharmacokinetics, are also discussed, and the main applications of IONPs are reviewed. Synthesis and properties of iron-oxide nanoparticlesSPIO and USPIO nanoparticles are the most extensively studied magnetic nanoparticles for biomedical applications as they are both biocompatible and easy to synthesize. Both are composed of ferrite nanocrystallites of magnetite (Fe 3 O 4 ) or maghemite (Fe 2 O 3 , γ). Over the last ten years, there has been an explosion of interest in these materials and this has been reflected in a large number of recent publications describing the synthesis and modifi cation of hybrid IONPs. In this review, we focus on the polymer modifi cation of the nanoparticles, and provide only minimal information on the inorganic synthesis of IONPs. For more detailed information on IONP synthesis, readers are referred to other reviews [3,4]. The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applicationsCyrille Boyer 1 * , Michael R. Whittaker 1 , Volga Bulmus 2 , Jingquan Liu 1 and Thomas P. Davis 1 * University of New South Wales, AustraliaOver the past decade, the synthesis of superparamagnetic nanoparticles, especially iron-oxide nanoparticles (IONPs), has been researched intensively for many high-technology applications, including enhanced storage media, biosensing and medical applications. In medicine, IONPs are used as contrast agents in magnetic resonance imaging and in hyperthermia...

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“…To conjugate PEG to particles, different anchoring groups such as silane, 11,12 dopamine, 13 phosphate, 14 nitrodopamine, 15 and multidentate catechol have been already utilized. 16 Xie et al transferred and stabilized oleic acid/oleylamine coated NPs by PEG-dopamine and demonstrated a remarkable reduction in non-specific uptake by macrophage cells.…”

Section: Introductionmentioning

confidence: 99%

Highly stable monodisperse PEGylated iron oxide nanoparticle aqueous suspensions: a nontoxic tracer for homogeneous magnetic bioassays

et al. 2013

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CitationHighly Uniformly sized and shaped iron oxide nanoparticles with a mean size of 25 nm were synthesized via decomposition of ironoleate. High resolution transmission electron microscopy and Mössbauer spectroscopy investigations revealed that the particles are spheres primarily composed of Fe 3 O 4 with a small fraction of FeO. From Mössbauer and static magnetization measurements, it was deduced that the particles are superparamagnetic at room temperature. The hydrophobic particles were successfully transferred into water via PEGylation using nitrodopamine as an anchoring group. IR spectroscopy and thermogravimetric analysis showed the success and efficiency of the phase transfer reaction. After the PEGylation, the particles retained monodisperse and their magnetic core remained intact as proven by photon cross-correlation spectrocopy, ac susceptibility, and transmission electron microscopy. The particle aqueous suspensions revealed an excellent water stability over a month of monitoring and also against temperature up to 40 • C. The particles exhibited a moderate cytotoxic effect on in vitro cultured bone marrow-derived macrophages and no release of inflammatory or anti-inflammatory cytokines. The PEGylated particles were functionalized with Herceptin antibodies via a conjugation chemistry, their response to a rotating magnetic field was studied using a fluxgate-based setup and was compared with the one recorded for hydrophobic and PEGylated particles. The particle phase lag rose after labeling with Herceptin, indicating the successful conjugation of Herceptin antibodies to the particles.

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Antibiofouling Polymer-Coated Superparamagnetic Iron Oxide Nanoparticles as Potential Magnetic Resonance Contrast Agents for in Vivo Cancer Imaging

Cited by 575 publications

References 54 publications

Nanoparticle delivery of anti-metastatic NM23-H1 gene improves chemotherapy in a mouse tumor model

Nanoparticle delivery of anti-metastatic NM23-H1 gene improves chemotherapy in a mouse tumor model

The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine applications

Highly stable monodisperse PEGylated iron oxide nanoparticle aqueous suspensions: a nontoxic tracer for homogeneous magnetic bioassays

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