Antibiofouling Zwitterionic Gradational Membranes with Moisture Retention Capability and Sustained Antimicrobial Property for Chronic Wound Infection and Skin Regeneration

Abstract

Nonadherent wound dressings with moisture management and long-lasting antibacterial properties have great significance for wound healing clinically. Herein, a novel multicomponent zwitterionic gradational membrane is fabricated by a co-electrospinning method to realize low biofouling and favorable moisture control as well as longacting antibacterial properties during the chronic woundhealing process. The obtained membrane possesses excellent anti-biofouling performance that effectively resists protein, bacteria, and cell adhesion according to in vitro antifouling evaluation. Furthermore, the gradational co-electrospinning method grants the composite membrane with moisture retention capability which could effectively absorb wound exudate and maintain a moisture healing environment. Additionally, in vivo and in vitro antibacterial investigations reflect that the composite membrane has excellent long-acting antibacterial property. Moreover, in vivo wound healing assessment confirms that the prepared membrane significantly reduces the complete wound healing time than commercial wound dressing. These results highlight such a zwitterionic gradational membrane as an advanced wound dressing to meet the various requirements for chronic wound infection and skin tissue regeneration in clinical applications.

Poly(ionic liquid)/Ce‐Based Antimicrobial Nanofibrous Membrane for Blocking Drug‐Resistance Dissemination from MRSA‐Infected Wounds

“…Although the protein adsorption mechanism is not yet completely understood, what is known that the more hydrophobic surface usually lead to higher protein adsorption because of the hydrophobic interaction between protein and the membrane surface. [ 58,59 ] The biocompatibility of materials is also essential for medical applications. Herein, the in vitro toxicity of the PIL membranes was evaluated by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide (MTT) and hemolysis assays, respectively.…”

Fluorescent carbon dots with excellent moisture retention capability for moisturizing lipstick

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Eradication of Mature Bacterial Biofilms with Concurrent Improvement in Chronic Wound Healing Using Silver Nanoparticle Hydrogel Treatment

“…To demonstrate the in vivo potential of the AgNP hydrogel, an established S. aureus (Xen 29) mouse model of mature biofilm wound infection. Wounds were inoculated with S. aureus (Xen 29) (5 × 10 7 CFU) and biofilms allowed to mature and establish by covering the wounds with a transparent Tegaderm dressing, which is known to promote bacterial proliferation, as facilitated by a moist environment, leading to the establishment of dense and stabilized mature biofilms in the first 48 h [48,49]. Following the establishment of mature biofilms as evident by the presence of thick extracellular polymeric substance [50], the daily treatment with AgNP hydrogel commenced on day 2 and was monitored in real-time for 10 days using IVIS bioluminescent imaging (Figure 4A).…”