Antibiogram of bacterial species isolated from canine pyometra

Bassessar, Varun; Verma, Yamini; Swamy, Madhu

doi:10.5455/vetworld.2013.546-549

Cited by 14 publications

(18 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been established that if E. coli migrates to the uterus, it binds with higher affinity to the endometrium and myometrium layers and constitutes a resistance to the uterus' defense mechanisms such as lactoferrin and mucin-1 [24][25][26][27] . As reported in previous studies [4,11,23,28] , gram negative bacteria (75%) such as E. coli, Klebsiella spp. and Ps.…”

Section: Discussionsupporting

confidence: 64%

Köpeklerde Endotoksik Pyometranın Klinik, Bakteriyolojik ve Histopatolojik Özellikleri

Demırel¹,

Vural²,

Vural³

et al. 2018

Kafkas Univ Vet Fak Derg

View full text Add to dashboard Cite

The object of this study was to compare the histopathologic change in uterus as well as the findings of clinical and bacteriological of twentyfour bitches with pyometra. Uterine lesions were grouped as acute endometritis, subacute endometritis, acute metritis, subacute metritis. Complete blood-count, blood biochemical parameters and toxin levels were determined. Only alkaline phosphatase levels were significantly different between all groups (P<0.01). Blood endotoxin level was different between the acute and subacute endometritis groups (P<0.01), and subacute endometritis and acute metritis groups (P<0.01). All bitches in the subacute endometritis group recovered. Three bitches in the acute endometritis group, two bitches in the acute metritis group and one bitch in the subacute metritis group died. The blood endotoxin level was determined to be quite high in the dead bitches. There was a difference in the levels of blood urea nitrogen (P<0.05), creatinine (P<0.01), and toxin (P<0.0001) between the dead and surviving bitches. In conclusion, the prognosis of pyometra may be recovered in bitches diagnosed with subacute endometritis associated with low levels of circulating endotoxin. The endotoxemic bitches that have blood endotoxin level above 0.96 EU/mL along with significantly increased alkaline phosphatase, blood urea nitrogen, and creatinine concentration would likely end up with a mortality outcome for acute endometritis, acute metritis, or subacute metritis. These parameters may serve as good prognostic markers in bitches with pyometra. Keywords: Bacteriology, Bitch, Histopathology, Prognosis, Pyometra Köpeklerde Endotoksik Pyometranın Klinik, Bakteriyolojik ve Histopatolojik Özellikleri ÖzBu çalışmanın amacı, pyometralı yirmi dört köpeğin uteruslarındaki histopatolojik değişikliklerin karşılaştırılmasıdır. Uterus lezyonları akut endometritis, subakut endometritis, akut metritis, subakut metritis olarak gruplandırıldı. Tam kan sayımı, kan biyokimyasal parametreler ve toksin seviyeleri belirlendi. Tüm gruplar arasındaki farklılık sadece alkalen fosfotaz seviyesinde önemliydi (P<0.01). Kan endotoksin seviyesi, akut ve subakut endometritis grupları (P<0.01) ile subakut endometritis ve akut metritis grupları (P<0.01) arasında farklıydı. Subakut endometritis grubundaki tüm köpekler iyileşti. Akut endometritis grubunda üç köpek, akut metritis grubunda iki köpek ve subakut metritis grubunda ise bir köpek öldü. Kan endotoksin seviyesinin ölen köpeklerde oldukça yüksek seviyede olduğu belirlendi. Ölen ve yaşayan köpekler arasında kan üre nitrojen (P<0.05), kreatinin (P<0.01) ve toksin (P<0.0001) seviyelerinin farklı olduğu görüldü. Sonuç olarak, dolaşımdaki endotoksinin düşük seviyesi ile ilişkili olarak subakut endometritis tanısı konulan köpeklerde pyometranın prognozunun iyileştirilebileceği düşünüldü. Yüksek seviyede alkalen fosfotaz, kan üre azotu ve kreatinin konsantrasyonu ile birlikte 0.96 EU/mL'nin üstündeki kan endotoksin düzeyine sahip endotoksemik köpeklerde akut endometritis, akut metritis veya ...

show abstract

Section: Discussionsupporting

confidence: 64%

Köpeklerde Endotoksik Pyometranın Klinik, Bakteriyolojik ve Histopatolojik Özellikleri

Demırel¹,

Vural²,

Vural³

et al. 2018

Kafkas Univ Vet Fak Derg

View full text Add to dashboard Cite

show abstract

“…It is plausible that the success rate would be higher if only less severely affected bitches are selected for medical treatment. Treatment outcome may also differ depending on varying antimicrobial resistance in different countries, but few studies focus on the choice of antimicrobial drugs used as adjunctive treatment of pyometra [6,8]. Until now, the overall outcome after aglepristone treatment of pyometra in Sweden has not been studied.…”

Section: Introductionmentioning

confidence: 96%

“…The pathogenesis of pyometra is not fully understood, but the influence of estrogen followed by subsequent progesterone stimulation during a long period of time (metoestrus) [4], in combination with bacterial infection, is believed to cause the disease. The bacteria originate from the normal flora of each bitch, and (E. coli) is the most common isolate from the uterus [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

A retrospective study of bitches with pyometra, medically treated with aglepristone

2014

View full text Add to dashboard Cite

Pyometra is a common and life-threatening disease of intact bitches caused by hormonal influence of the uterus in combination with bacterial infection. The treatment of choice is ovariohysterectomy, but several purely medical options are available. Common drugs used for medical treatment in combination with antimicrobials are progesterone receptor blockers, prostaglandins, and dopamine agonists. The aim of this study was to evaluate long-term recovery and fertility after treatment with the progesterone receptor blocker aglepristone in bitches with pyometra. Data from 28 bitches with pyometra, admitted to the University Animal Hospital, Swedish University of Agricultural Sciences, during a 9-year period, were studied retrospectively and followed up by telephone interviews with the owners. The bitches had been treated with aglepristone at a dose of 10 mg/kg on a median of four occasions. All bitches had also been treated with antimicrobial drugs for a mean duration of 23 days, the most frequently used being enrofloxacin. Escherichia coli were the most commonly isolated bacteria from cranial vagina. The outcome was assessed for up to 6 years after treatment. The success rate, determined as restored clinically healthy status, was 75% (21/28 bitches), and the recurrence rate of disease was 48% (10/21 bitches). The mean time until recurrence was 10.5 months after the end of treatment. After treatment, 69% (9/13) of the mated bitches produced puppies. Of the seven bitches that did not have a successful treatment, six were ovariohysterectomized and one was euthanized. In conclusion, medical treatment with aglepristone in combination with antimicrobial therapy was successful in 75% of the bitches studied and the recurrence rate was 48%.

show abstract

“…; Bassessar et al. ). CEH can cause mucometra leading to endometrial thickening with the accumulation of viscid, sterile fluid in the uterus but in pyometra this fluid is contaminated with bacteria (Hardy and Osborne ; Pretzer ).…”

Section: Introductionmentioning

confidence: 97%

Measurement of C‐reactive protein and Prostaglandin F_2α Metabolite Concentrations in Differentiation of Canine Pyometra and Cystic Endometrial Hyperplasia/Mucometra

Enginler

Ateş

Sığırcı

et al. 2014

Reprod Domestic Animals

View full text Add to dashboard Cite

Canine pyometra is a dioestrus period disease in which systemic inflammatory response syndrome (SIRS) is a common outcome due to the response of the body to the bacterial infection. The purpose of this study was i) to differentiate canine pyometra and cystic endometrial hyperplasia (CEH)/mucometra by measuring serum C-reactive protein (CRP) and prostaglandin F2α metabolite (PGFM) concentrations in blood and ii) to compare serum concentrations of CRP and PGFM in bitches with a pathological uterus (pyometra or CEH/mucometra) to concentrations in bitches with a healthy uterus. Mean CRP concentrations were found significantly higher (p < 0.001) in dogs with pyometra compared to those with CEH/mucometra or healthy uterus. However, no statistical difference could be detected between the groups for mean PGFM concentrations. Mean white blood cell count (WBC), alkaline phosphatase (ALP) and total protein concentrations were found significantly higher (p < 0.001) in dogs with pyometra. Escherichia coli was the most frequently isolated microorganism from dogs with pyometra (64.3%). Edwardsiella spp. was detected in a single case of pyometra for the first time. In conclusion, our results demonstrate that serum CRP concentrations were increased in dogs with pyometra and thus we conclude that serum CRP concentration but not PGFM might be useful as a marker to differentiate a case of CEH/mucometra from pyometra in female dogs. To the authors' knowledge, this is the first report in which Edwardsiella spp. has been isolated in the canine uterus.

show abstract

Antibiogram of bacterial species isolated from canine pyometra

Cited by 14 publications

References 0 publications

Köpeklerde Endotoksik Pyometranın Klinik, Bakteriyolojik ve Histopatolojik Özellikleri

Köpeklerde Endotoksik Pyometranın Klinik, Bakteriyolojik ve Histopatolojik Özellikleri

A retrospective study of bitches with pyometra, medically treated with aglepristone

Measurement of C‐reactive protein and Prostaglandin F_2α Metabolite Concentrations in Differentiation of Canine Pyometra and Cystic Endometrial Hyperplasia/Mucometra

Contact Info

Product

Resources

About

Antibiogram of bacterial species isolated from canine pyometra

Cited by 14 publications

References 0 publications

Köpeklerde Endotoksik Pyometranın Klinik, Bakteriyolojik ve Histopatolojik Özellikleri

Köpeklerde Endotoksik Pyometranın Klinik, Bakteriyolojik ve Histopatolojik Özellikleri

A retrospective study of bitches with pyometra, medically treated with aglepristone

Measurement of C‐reactive protein and Prostaglandin F2α Metabolite Concentrations in Differentiation of Canine Pyometra and Cystic Endometrial Hyperplasia/Mucometra

Contact Info

Product

Resources

About

Measurement of C‐reactive protein and Prostaglandin F_2α Metabolite Concentrations in Differentiation of Canine Pyometra and Cystic Endometrial Hyperplasia/Mucometra