Antibiogram of klebsiella pneumoniae recovered from blood stream infection at tertiary care hospital, Baroda, Gujarat

Abstract

Introduction: Antimicrobial abuse is a serious risk factor for the emergence of multi-drug-resistant (MDR) pathogens. Multidrug resistant (MDR) Klebsiella pneumoniae is an increasing cause of blood stream infections in India and in other developing countries. Aim: This study was undertaken to determine the prevalence of Klebsiella pneumoniae in blood stream infections and their susceptibility pattern at S. S. G. Hospital, Baroda. Material and Methods: 169 isolates of Klebsiella pneumoniae were obtained from blood culture samples from hospitalized patients. K.pneumoniae species were identified based on biochemical reactions. Their sensitivity pattern were checked by Kirbybauer disc diffusion technique as per CLSI guideline. Antimicrobial discs used were Ceftazidime (30µg), Cefotaxime (30µg), Imipenem (10 µg), Levofloxacin (5 µg), Aztreonam (30 µg), Co-trimoxzole (25 µg), Ampicilin (10 µg), Gentamicin (10 µg), Amikacin (30 µg), Doxycycline (30 µg). Results: 950 blood cultures were studied from suspected patients and the prevalence of K. pneumoniae among them was checked with its antimicrobial susceptibility at Department of Microbiology, Tertiary care hospital, Gujarat. Among 950 suspected patients in the study period, K.pneumoniae was found in 169 blood culture samples. Conclusion: Infections with K.pneumoniae are increasing, particularly among paediatric patients. This pathogen is usually multidrug-resistant and there are limited treatment options available. This result warns us for implementation of infection control measures to limit intra-institutional spread of these organisms.

Antimicrobial susceptibility pattern and phenotypic detection of metallo-beta lactamases in K. pneumoniae isolates in a tertiary care hospital

“…The study is quite similar to the studies done by Bhavsar et al, who reported 64.5% isolated from male patients and 35.5% from female patients. 28 Su et al, also reported 63.2% isolates from male and 36.8% female patients. 29 However Muzaheed et al, reported higher number of isolates from male patients (80.1%) and lesser from female patients (19.8%).…”