Antibiogram of multidrug resistant Acinetobacter baumannii isolated from clinical specimens at King Hussein Medical Centre, Jordan: a retrospective analysis

Batarseh, Adel; Alsarhan, Ali; Maayteh, M; Al-Khatirei, S; Al-Armouti, Majed

doi:10.26719/2015.21.11.828

Cited by 20 publications

(13 citation statements)

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“…Developing of multi-drug resistant A. baumannii in the hospital could be due to lack of proper infection-control performance, the patient's normal bacterial flora under the aggressive antibiotics, or contaminated instruments, and overcrowding situations in the hospitals. In the present study, the higher rate of A. baumannii was found in male compared to females as in Table 2, 3, which is in agreement with observations in previous studies due to their exposing to the bacteria in environments (Oncul et al, 2009, Batarseh et al, 2015, Hatami, 2018. The predominance of male patients infected with Acinetobacter has been confirmed in other studies but the cause is not justified (Uwingabiye et al, 2016).…”

Section: Resultssupporting

confidence: 93%

“…In the present study, the resistance rate of isolates to colistin was (0%), studies in Turkey and Iran (Ozdemir et al, 2011, Sarhaddi et al, 2017, reported the antibiotics with the highest in vitro susceptibility was colistin, 100 % susceptible against A. baumannii other data reported from Jordan (1.7%), and (0.5%) in Saudi Arabia (Batarseh et al, 2015, Al-Mously, 2013. In contrast, a study from Iran (Sepahvand et al, 2015) reported that 6% of the isolates were resistant to colistin which was a higher rate of resistance when compared with our result.…”

Section: Resultssupporting

confidence: 54%

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Prevalence of infections with antibiotic-resistant Acinetobacter baumannii in different clinical samples from hospitals in Erbil

2020

ZJPAS

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is one of the important pathogen causing nosocomial infections. This pathogen is Acinetobacter baumannii resistant-Drug rbidity. The aim of the study becoming resistant to a large group of antimicrobial agents, leading to a high rate of mortality and mo isolates from different clinical samples and analyze its antibiotic obacter baumannii Acinet the prevalence of to determine was. During the period of study from November 2016 to December 2017, different rofiles, and pathogenic perspective susceptibility p swab, burn, sputum and blood) obtained from patients hospitalized in Par private clinical specimens including (urine, wound A. hospital and Rizgari teaching hospital in Erbil city. Conventional microbiological methods were used for identification of performed by the method commended by the Clinical Laboratory and Standards. Antibiotic susceptibility testing was baumannii nosocomial infection was increasing especially in patients with risk factors, the current study baumannii A. Institute (CLSI). baumannii A. countered 20 (51.3%) followed by others. The prevalence of showed that sputum isolates are the most frequently en 3 25 1 1 14 12 3 T ce, most of the isolates even non susceptible to carbapenems with the revealed that there was an increase in antimicrobial resistan drug-exception of colistin that had an effective rule in comparison with the others. The study showed that the incidence of multi A. nce in A. baumannii to carbapenems was rising. Most isolates of was high and the rate of resista A. baumannii resistance resistance against antibiotics.-were multi baumannii

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Section: Resultssupporting

confidence: 93%

Section: Resultssupporting

confidence: 54%

Prevalence of infections with antibiotic-resistant Acinetobacter baumannii in different clinical samples from hospitals in Erbil

2020

ZJPAS

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“…The rate of CRAB in our country is close to that of areas as remote as Jordan (97·4%) (Batarseh et al . ), but exceeded the rates described above and that reported in other Middle East countries such as Syria (64·4%) (Hamzeh et al . ), Saudi Arabia (32·6–51·9%) (Abdalhamid et al .…”

Section: Resultscontrasting

confidence: 52%

Trend of extensively drug-resistantAcinetobacter baumanniiand the remaining therapeutic options: a multicenter study in Tehran, Iran over a 3-year period

Jasemi

Douraghi

Adibhesami

et al. 2016

Lett Appl Microbiol

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The high frequency of drug-resistant phenotypes including carbapenem-resistant Acinetobacter baumannii, multidrug-resistant, and extensively resistant has been demonstrated in Ac. baumannii isolates tested here. As the antibiotic resistance pattern of isolates varies in different geographical regions, this study can provide comprehensive information about the antibiotic resistance profile of Ac. baumannii isolates in Tehran. In addition, the resistance profiles could be effectively considered by clinicians to manage antibiotic therapy. This work also emphasizes on the prudent use of antibiotics and the monitoring of antibiotic susceptibility trend and rate.

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“…This pattern of antibiotic resistance often varies with time and from one area to another or even within the same area. 3,4 Nowadays, in developing countries, including Iran, physicians face serious challenges to the treatment of patients infected with MDR A. baumannii, presenting severe healthcare problems owing to treatment failure. 5,6 Carbapenem antibiotics, such as imipenem and meropenem, are the most effective therapeutic options for A. baumannii infections.…”

Section: Introductionmentioning

confidence: 99%

<p>Survey on Genetic Diversity, Biofilm Formation, and Detection of Colistin Resistance Genes in Clinical Isolates of <em>Acinetobacter baumannii</em></p>

Khoshnood¹,

Savari²,

Montazeri³

et al. 2020

IDR

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Introduction: Acinetobacter baumannii is an opportunistic pathogen responsible for nosocomial infections. The emergence of colistin-resistant A. baumannii is a significant threat to public health. The aim of this study was to investigate the molecular characterization and genotyping of clinical A. baumannii isolates in Southwestern Iran. Methods: A total of 70 A. baumannii isolates were collected from patients admitted to Imam Khomeini Hospital in Ahvaz, Southwestern Iran. Minimum inhibitory concentration test was conducted by using Vitek 2 system. The presence of biofilm-forming genes and colistin resistance-related genes were evaluated by PCR. The isolates were also examined for their biofilm formation ability and the expression of pmrA and pmrB genes. Finally, multilocus sequence typing (MLST) and PCR-based sequence group were used to determine the genetic relationships of the isolates. Results: Overall, 61 (87.1%) and 9 (12.8%) isolates were multidrug-resistant (MDR) and extensively drug-resistant (XDR), respectively. Colistin and tigecycline with 2 (2.8%) and 32 (45.7%) resistance rates had the highest effect. Among all the isolates, 55 (78.5%), 7 (10%), and 3 (4.3%) were strong, moderate, and weak biofilm producers, respectively. The frequency rates of biofilm-related genes were 64 (91.4%), 70 (100%), 56 (80%), and 22 (31.42%) for bap, ompA, csuE, and bla PER1 , respectively. Overexpression of pmrA and pmrB genes was observed in two colistin-resistance isolates, but the expression of these genes did not change in colistin-sensitive isolates. Additionally, 37 (52.8%) and 8 (11.4%) isolates belonged to groups 1 (ICII) and 2 (IC I), respectively. MLST analysis revealed a total of nine different sequence types that six isolates belonged to clonal complex 92 (corresponding to ST801, ST118, ST138, ST 421, and ST735). Other isolates were belonging to ST133 and ST216, and two colistin-resistant (Ab4 and Ab41) isolates were belonging to ST387 and ST1812. Conclusion: The present study revealed the presence of MDR and XDR A. baumannii isolates harboring biofilm genes and emergence of colistin-resistant isolates in Southwestern Iran. These isolates had high diversity, which was affirmed by typing techniques. The control measures and regular surveillance are urgently needed to preclude the spread of these isolates.

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Antibiogram of multidrug resistant Acinetobacter baumannii isolated from clinical specimens at King Hussein Medical Centre, Jordan: a retrospective analysis

Cited by 20 publications

References 23 publications

Prevalence of infections with antibiotic-resistant Acinetobacter baumannii in different clinical samples from hospitals in Erbil

Prevalence of infections with antibiotic-resistant Acinetobacter baumannii in different clinical samples from hospitals in Erbil

Trend of extensively drug-resistantAcinetobacter baumanniiand the remaining therapeutic options: a multicenter study in Tehran, Iran over a 3-year period

<p>Survey on Genetic Diversity, Biofilm Formation, and Detection of Colistin Resistance Genes in Clinical Isolates of <em>Acinetobacter baumannii</em></p>

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