Antibiotic and Oral Contraceptive Drug Interactions: Is There a Need for Concern?

Zhanel, George G.; Siemens, Shannon; Slayter, Kathryn; Mandell, Lionell

doi:10.1155/1999/539376

Cited by 17 publications

(17 citation statements)

References 25 publications

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“…There are three categories of antibiotic agents that range from those that are likely to reduce the effectiveness of OCPs (rifampin), those that are associated with OCP failure in three or more reported cases (ampicillin, amoxicillin, metronidazole, and tetracycline), and those that were associated with OCP failure in at least one case report (cephalexin, clindamycin, dapsone, erythromycin, griseofulvin, isoniazid, phenoxymethylpenicillin, talampicillin, and trimethoprim; Miller et al, 1994 ). A conservative approach is the recommend use of a second form of contraception while taking a systemic antibiotic agent ( Zhanel et al, 1999 ), but evidence for this is very limited ( Miller et al, 1994 ).…”

Section: Systemic Antibiotic Medicationsmentioning

confidence: 99%

A review of diagnosis and treatment of acne in adult female patients

Tan

Schlosser

Paller

2018

International Journal of Women's Dermatology

188

166

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This review focuses on the treatment options for adult female patients with acne. Acne in adult female patients may start during adolescence and persist or have an onset in adulthood. Acne has various psychosocial effects that impact patients’ quality of life. Treatment of acne in adult women specifically has its challenges due to the considerations of patient preferences, pregnancy, and lactation. Treatments vary widely and treatment should be tailored specifically for each individual woman. We review conventional therapies with high levels of evidence, additional treatments with support from cohort studies and case reports, complementary and/or alternative therapies, and new agents under development for the treatment of patients with acne.

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Section: Systemic Antibiotic Medicationsmentioning

confidence: 99%

A review of diagnosis and treatment of acne in adult female patients

Tan

Schlosser

Paller

2018

International Journal of Women's Dermatology

188

166

View full text Add to dashboard Cite

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“…Other effects of alcohol on antibiotic activity include the altered activity of the liver enzymes that break down the antibiotic compound. 31 A bactericidal activity of antibacterial may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. These findings are based on laboratory studies, and in clinical settings have also been shown to eliminate bacterial infection.…”

Section: Alcoholmentioning

confidence: 99%

Review on a Potential of Antibiotics

Singh

Verma

Kumar

et al. 2018

J. Drug Delivery Ther.

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Observations about the growth of some microorganisms inhibiting the growth of other microorganisms have been reported since the late 1800s. These observations of antibiosis between microorganisms led to the discovery of natural antibacterial. This paper deliberates important findings of the educations conducted by numerous national and international combined organizations on a brief indication of the antibacterial agents׳ detection in recent years. In India especially the developing antibiotics, need to institute methods for the suitable choice of drug conduct a compound problem involving prescribers, dispensers, and consumers. Keywords: Antibiotic, Antibiotic resistance, bacterial Infection

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“…The study population comprised 364 women with a median age of 23 [interquartile range (IQR) [19][20][21][22][23][24][25][26][27][28][29]. Of these, 40…”

Section: Resultsmentioning

confidence: 99%

“…Lastly, the generally limited statistical precision of the estimates is in play, as our results are also compatible with a 50% increased risk of unintended pregnancy. It has previously been suggested that use of antibiotics in general might influence the use of oral contraceptives [20,21]. With the exception of rifampicin, which has been shown to confer a risk of oral contraceptive failure [22], this alleged risk has largely been 'debunked' [23].…”

Section: Discussionmentioning

confidence: 99%

Use of Dicloxacillin and Risk of Pregnancy among Users of Oral Contraceptives

Pottegård

Broe

Stage

et al. 2018

Basic Clin Pharma Tox

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The antibiotic dicloxacillin has been shown to induce drug-metabolizing CYP enzymes to a clinically relevant extent. In this study, we investigated whether the use of dicloxacillin confers an increased risk of unwanted pregnancy among oral contraceptive users. The study population comprised Danish women falling pregnant (1997-2015) during oral contraceptive use, defined as having filled a prescription for an oral contraceptive within 120 days both before and after the estimated date of conception. Data were analysed using a case-crossover approach. For each woman, we assessed the use of dicloxacillin preceding the date of conception and during 10 previous control periods and estimated the odds ratio for such unintended pregnancies associated with the use of dicloxacillin. Among 364 women using dicloxacillin prior to conception, 40 (11%) were exposed to dicloxacillin at the time of conception, yielding an odds ratio (OR) associating use of dicloxacillin to unintended pregnancy of 1.18 (95% CI 0.84-1.65). Supplementary and sensitivity analyses generally returned similar estimates, except for a slightly increased risk among users of progestogen-only oral contraceptives (OR 1.83, 95% CI 0.63-5.34). Analysis of other antibiotics as negative controls yielded results close to unity (ORs ranging from 0.83 to 1.13). In conclusion, our study found no evidence for an increased risk of oral contraceptive failure when using dicloxacillin. However, acknowledging study limitations, we suggest the use of supplementary barrier methods during treatment with dicloxacillin, until our findings are confirmed in further studies.

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Antibiotic and Oral Contraceptive Drug Interactions: Is There a Need for Concern?

Abstract: Rifampin is the only antibiotic to date that has been reported to reduce plasma estrogen concentrations. Oral contraceptives cannot be relied upon for birth control while taking rifampin.

Cited by 17 publications

References 25 publications

A review of diagnosis and treatment of acne in adult female patients

A review of diagnosis and treatment of acne in adult female patients

Review on a Potential of Antibiotics

Use of Dicloxacillin and Risk of Pregnancy among Users of Oral Contraceptives

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