Antibiotic-Associated Diarrhea and Cl. Difficile-Infection in Children: Risk Factors

Мазанкова, Л. Н.; Перловская, С. Г.

doi:10.22627/2072-8107-2015-14-2-29-34

Cited by 4 publications

References 54 publications

(60 reference statements)

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Clinical case of complicated and recurrent course of Cl. difficile-associated colitis in a child under 1 year of age

Tumash,

Sergeichik

2024

jour

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Currently, antibiotic-associated diarrhea caused by Clostridioides difficile (Cl. difficile) is one of the problems of the health care system in many countries of the world and the main causative agent of healthcare-associated infections. The article describes a clinical case from our own practice of the occurrence of Cl. difficile associated diarrhea (CDI) in a child in the first year of life. In the described clinical case, the child developed the first episode of CDI against the background of antibiotic therapy, which, due to the inadequate duration of treatment, led to a relapse of the disease and the development of complications in the form of sepsis. Thus, with clinical case, we want to draw the attention of practitioners to the problem of CDI in young children. Currently, despite significant changes in the diagnosis of CDI, the diagnosis of CDI in young children is challenging, requiring the development of accurate diagnostic criteria for diagnosis and the definition of additional diagnostic markers to distinguish healthy carriage from disease.

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Clinical case of complicated and recurrent course of Cl. difficile-associated colitis in a child under 1 year of age

Tumash,

Sergeichik

2024

jour

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Clinico-Etiological Characteristics of Acute Intestinal Infections in Hospitalized Children of Moscow in 2015—2017

Молочкова¹,

Ковалев²,

Россина³

et al. 2018

Det. infekc.

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A retrospective analysis of the etiological structure and clinical manifestations of acute intestinal infections was conducted in 8459 children hospitalized in a specialized infectious disease department at the Children's City Clinical Hospital No.9 in Moscow, in 2015—2017 based on the study of statistical reports of the Children's City Clinical Hospital No.9 for 2015—2017 and 2417 case histories of children aged 1 month to 18 years old.It was found that children with age 1—7 years of age (58.5%) are more likely to have acute intestinal infections and are hospitalized. The etiological interpretation of acute intestinal infections remains at a low level and is 28.6%. The leading causative agents of acute intestinal infections are viruses (83%), mainly rotaviruses (62%), less often noroviruses (18%). Topical diagnosis in the vast majority of patients with acute intestinal infections was gastroenteritis (74.7%), which leads to the development of toxicosis with exsiccosis, especially in young children, which is the reason for hospitalization in the hospital. The share of bacterial diarrhea is small (17%), among them salmonella is significant, and in young children — staphylococcal infection. In recent years, the relevance of identifying campylobacter and clostridium, these pathogens may be the cause of the development of diarrhea with hemoccolitis.

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Clinical signs and post-mortem lesions caused by clostridial enterotoxemia in rabbits

Metleva,

Khakimzyanova,

Sionikhin

2024

Veterinariâ segodnâ

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Enterotoxemia, accompanied by diarrhea and bloating, is still a matter of pressing concern to the rabbit farming. Clostridia bacteria are often isolated from the internal organs of rabbits that have died of an anaerobic infection. Clostridial infection, manifested in various forms, is a major problem for veterinarians. The following drivers contribute to the emergence of the infectious disease: malnutrition (insufficient fiber intake); non-compliance with hygiene requirements for animal handling; unsustainable use of antibacterial drugs; gastrointestinal congestion. All these drivers can disrupt healthy caecum microflora due to changes in the gastrointestinal environment. Low-fiber diets result in slow cecum motility, thus, delaying transit of the intestinal contents and eventually changing the microflora. Use of antibiotics together with stress make Clostridia accumulate in the gastrointestinal tract, at the same time, reducing the number of microorganisms of other groups. The first signs of toxicoinfection are observed when rabbit kits are weaned from does. Clinical manifestation begins with bloating, weakness, inappetence, which ultimately lead to death. Observations have shown that the risk group includes rabbit kits weaned from the 35–77-day old does. Mortality was less reported in breeding stock and among replacement young animals. Autopsy revealed signs of enterotoxemia: serous-catarrhal gastritis, serous-hemorrhagic lymphonodulitis, degenerated kidneys, liver and heart muscle; passive congestion of lungs and pulmonary edema. Microbiological diagnosis revealed Clostridium histolyticum and Clostridium perfringens species known for their pronounced toxigenic profile, most often bacteria were found in the stomach, intestines and heart.

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Antibiotic-Associated Diarrhea and Cl. Difficile-Infection in Children: Risk Factors

Cited by 4 publications

References 54 publications

Clinical case of complicated and recurrent course of Cl. difficile-associated colitis in a child under 1 year of age

Clinical case of complicated and recurrent course of Cl. difficile-associated colitis in a child under 1 year of age

Clinico-Etiological Characteristics of Acute Intestinal Infections in Hospitalized Children of Moscow in 2015—2017

Clinical signs and post-mortem lesions caused by clostridial enterotoxemia in rabbits

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