Antibiotic cement-coated intramedullary nail is cost-effective for the initial treatment of GAⅢ open tibia fractures

Steflik, Michael J.; Griswold, B. Gage; Patel, Dhara V.; Blair, James A.; Davis, Jana M.

doi:10.1016/j.injury.2022.08.005

Cited by 3 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even with measures like thorough debridement, VSD, placement of antibiotic-loaded bone cement, and close monitoring of in ammatory indicators in this study, ve patients still experienced postoperative infections. Previous studies have suggested that antibiotic bone cement coating intramedullary nail can effectively prevent infection and enrich local blood supply in the treatment of fracture-related infections [49][50][51][52] . Considering an extended duration of antibiotic use after surgery also can play a role in infection control [53,54] .…”

Section: Discussionmentioning

confidence: 99%

Matched comparative study of 3D printed microporous tantalum prosthesis versus autologous bone graft in the final stage of Masquelet induced membrane surgery

Yang,

Xu,

Shi

et al. 2024

Preprint

View full text Add to dashboard Cite

Introduction: Masquelet induced membrane surgery is a viable option for the reconstruction of extensive bone defects. This study aimed to comprehensively compare the clinical efficacy of 3D printed microporous tantalum prosthesis and autologous bone graft in the final stage of Masquelet induced membrane surgery during the treatment of lower extremity osteomyelitis with large segmental bone defect. Methods A prospective analysis was conducted on 43 patients with large segmental bone defect caused by lower extremity osteomyelitis treated with Masquelet induced membrane surgery. Among these, 21 patients were implanted 3D printed microporous tantalum prosthesis (Prosthesis group), while 22 patients were implanted autologous bone graft (Autologous bone group) in the final-stage surgery. Follow-up was conducted for 12 months postoperatively. Clinical efficacy was evaluated using the Paley grade for bone defect healing, Visual analog scale (VAS), Lower extremity functional scale (LEFS), Fernandez-Esteve eschar score, and time to full weight-bearing. The clinical outcomes between the two treatment groups were compared. Results Postoperatively, the scores of VAS and LEFS significantly improved compared to preoperative values in both groups (all P < 0.001). Compared to the Autologous bone group, the Prosthesis group demonstrated significantly higher LEFS scores and Fernandez-Esteve eschar scores, along with a significantly shorter time to full weight-bearing (all P < 0.05). Conclusion Both implants show remarkable efficacy in the reconstruction of large segmental bone defect caused by lower extremity osteomyelitis. However, 3D printed microporous tantalum prosthesis exhibits certain advantages over the autologous bone graft in terms of limb function recovery, bone callus growth, and early weight-bearing.

show abstract

Section: Discussionmentioning

confidence: 99%

Matched comparative study of 3D printed microporous tantalum prosthesis versus autologous bone graft in the final stage of Masquelet induced membrane surgery

Yang,

Xu,

Shi

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Financial Analysis of Preoperative Nasal Decolonization With Povidone-Iodine in Closed Pilon Fracture Definitive Fixation

Barker,

Harimtepathip,

Steflik

et al. 2024

The Journal of Foot and Ankle Surgery

View full text Add to dashboard Cite

Biofilm Formation, Antibiotic Resistance, and Infection (BARI): The Triangle of Death

Giordano,

Giannoudis

2024

JCM

View full text Add to dashboard Cite

Fracture-related infection (FRI) is a devastating event, directly affecting fracture healing, impairing patient function, prolonging treatment, and increasing healthcare costs. Time plays a decisive role in prognosis, as biofilm maturation leads to the development of antibiotic resistance, potentially contributing to infection chronicity and increasing morbidity and mortality. Research exploring the association between biofilm maturation and antibiotic resistance in orthopaedics primarily addresses aspects related to quality of life and physical function; however, little exists on life-threatening conditions and mortality. Understanding the intrinsic relationship between biofilm maturation, bacterial resistance, and mortality is critical in all fields of medicine. In the herein narrative review, we summarize recent evidence regarding biofilm formation, antibiotic resistance, and infection chronicity (BARI), the three basic components of the “triangle of death” of FRI, and its implications. Preoperative, perioperative, and postoperative prevention strategies to avoid the “triangle of death” of FRI are presented and discussed. Additionally, the importance of the orthopaedic trauma surgeon in understanding new tools to combat infections related to orthopaedic devices is highlighted.

show abstract

Antibiotic cement-coated intramedullary nail is cost-effective for the initial treatment of GAⅢ open tibia fractures

Cited by 3 publications

References 16 publications

Matched comparative study of 3D printed microporous tantalum prosthesis versus autologous bone graft in the final stage of Masquelet induced membrane surgery

Matched comparative study of 3D printed microporous tantalum prosthesis versus autologous bone graft in the final stage of Masquelet induced membrane surgery

Financial Analysis of Preoperative Nasal Decolonization With Povidone-Iodine in Closed Pilon Fracture Definitive Fixation

Biofilm Formation, Antibiotic Resistance, and Infection (BARI): The Triangle of Death

Contact Info

Product

Resources

About