Antibiotic Choices for Pediatric Periorbital Cellulitis—A 20-Year Retrospective Study from Taiwan

Abstract

The delayed treatment of pediatric periorbital cellulitis may have severe consequences. In addition, the antibiotic efficacy against causative bacteria may change over time, and it is important to understand the appropriate antibiotic options for effective treatment in pediatric patients. We compared the changes in cultured bacteria and drug susceptibility tests between two decades, 2010–2019 and 2000–2009, to establish antibiotics for empirical use. The patient characteristics, etiologies, culture sites, and isolated bacteria, and the antibiotic susceptibility tests of the admitted pediatric patients (n = 207) diagnosed with preseptal and orbital cellulitis during 2000 to 2019, were recorded. Insect/animal bites (p = 0.084) showed an increasing trend, and sinusitis (p = 0.016) showed a significant decrease in the past decades. The most common bacteria were Staphylococcus aureus, and methicillin-resistant S. aureus (MRSA) infections increased in recent decades (p = 0.01). Moreover, we found that vancomycin was ideal for MRSA infections. The decreasing efficacy of oxacillin correlates with the increasing proportion of MRSA in pediatric periorbital cellulitis. Our study thus offers antibiotic choices against the most common isolates that can be administered before culture results are available.

Ophthalmia neonatorum complicated with neonatal orbital cellulitis: A case series

“… 13 , 14 Both ceftriaxone and cefotaxime are broad-spectrum antibiotics that cover a wide range of bacteria, including Streptococcus and Staphylococcus species, which are the most common causative organisms. 15 …”

Infección De Piel Y Partes Blandas, Tratamiento en Edad Pediátrica

“…En España se reportó que, la frecuencia de resistencia a la meticilina del Staphylococcus aureus se encontró entre el 9 y el 14,8%, como causante de infección de piel y tejidos blandos (2,9) (11).…”

Actualización diagnostica y tratamiento de Celulitis Periorbitaria en el paciente pediátrico

“…et al, 2018]. La celulitis preseptal se refiere a una infección limitada a los tejidos superficiales de los párpados y la piel adyacente, mientras que la inflamación postseptal, también denominada celulitis de la órbita, implica una infección del espacio posterior al septo orbitario [Cruz, L., et al, 2020] [Shih et al,2022. También existe otra clasificación ideada por Chandler et al, usada en la práctica actual en todo el mundo [Crosbie & Kubba 2016].…”