Antibiotic Compounds from &lt;i&gt;Bacillus&lt;/i&gt;: Why are they so Amazing?

Fickers, Patrick

doi:10.3844/ajbbsp.2012.38.43

Cited by 45 publications

(39 citation statements)

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“…Kurstakins form another family of LPs composed of four partially cyclic heptalipopeptides, which differ only in their fatty acid chains [145]. The gene clusters of the Bacillus LPs encoding the surfactin, fengycin, iturin and kurstakin families have been described and summarized in a number of recent reviews [6, 11, 136, 145]. Cerexins are linear LPs with strong antimicrobial activity against S. aureus and Streptococcus pneumoniae [146].…”

Section: Resultsmentioning

confidence: 99%

“…The discovery of biosynthetic gene clusters of antimicrobial compounds by genome mining is a rewarding task, because this methodology can lead to the identification and subsequent isolation of novel molecules of pharmacological and biotechnological interest [6]. Various powerful tools with broad databases have been created for the automated screening of bacteriocin gene clusters.…”

Section: Introductionmentioning

confidence: 99%

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Identification and classification of known and putative antimicrobial compounds produced by a wide variety of Bacillales species

2016

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BackgroundGram-positive bacteria of the Bacillales are important producers of antimicrobial compounds that might be utilized for medical, food or agricultural applications. Thanks to the wide availability of whole genome sequence data and the development of specific genome mining tools, novel antimicrobial compounds, either ribosomally- or non-ribosomally produced, of various Bacillales species can be predicted and classified. Here, we provide a classification scheme of known and putative antimicrobial compounds in the specific context of Bacillales species.ResultsWe identify and describe known and putative bacteriocins, non-ribosomally synthesized peptides (NRPs), polyketides (PKs) and other antimicrobials from 328 whole-genome sequenced strains of 57 species of Bacillales by using web based genome-mining prediction tools. We provide a classification scheme for these bacteriocins, update the findings of NRPs and PKs and investigate their characteristics and suitability for biocontrol by describing per class their genetic organization and structure. Moreover, we highlight the potential of several known and novel antimicrobials from various species of Bacillales.ConclusionsOur extended classification of antimicrobial compounds demonstrates that Bacillales provide a rich source of novel antimicrobials that can now readily be tapped experimentally, since many new gene clusters are identified.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-016-3224-y) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identification and classification of known and putative antimicrobial compounds produced by a wide variety of Bacillales species

2016

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“…This hope comes not only in the form of new antibacterial compounds, but also new sources of these compounds. Well known bacterial sources of antibiotics include Actinomycetes, predominantly from the genus Streptomyces (Watve et al, 2001), myxobacteria (Wenzel and Muller, 2009), cyanobacteria (Welker et al, 2012), Bacillus (Fickers, 2012;Hamdache et al, 2011) and Pseudomonas species (Gross and Loper, 2009). In the past, many antibiotics were discovered through antibacterial screening programs, usually by cultivating bacteria from soil samples and isolating their secondary metabolites (Zotchev G Model IJMM 50738 1-9 2 S.J.…”

Section: Introductionmentioning

confidence: 99%

Antibiotics from neglected bacterial sources

Pidot¹,

Coyne²,

Kloß³

et al. 2014

International Journal of Medical Microbiology

122

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“…8 Recent advances in genome sequencing have highlighted the genus Bacillus as a potential source of antibioticlike compounds such as polyketides, nonribosomal peptide, and bacteriocins as well as other unusual compounds. 19 The remaining isolates in our study belong to γ-proteobacteria.…”

Section: ■ Discussionmentioning

confidence: 99%

Polyketide Family of Novel Antibacterial 7-O-Methyl-5′-hydroxy-3′-heptenoate–Macrolactin from Seaweed-Associated Bacillus subtilis MTCC 10403

Chakraborty

Thilakan

Raola

2014

J. Agric. Food Chem.

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Seaweed-associated heterotrophic bacterial communities were screened to isolate potentially useful antimicrobial strains, which were characterized by phylogenetic analysis. The bacteria were screened for the presence of metabolite genes involved in natural product biosynthetic pathway, and the structural properties of secondary metabolites were correlated with the genes. Bioactivity-guided isolation of polyene antibiotic 7-O-methyl-5'-hydroxy-3'-heptenoate-macrolactin from Bacillus subtilis MTCC10403 associated with seaweed Anthophycus longifolius using mass spectrometry and extensive 2D-NMR studies was carried out. The newly isolated macrolactin compound is a bactericidal antibiotic with broad spectrum activity against human opportunistic clinical pathogens. The biosynthetic pathway of 7-O-methyl-5'-hydroxy-3'-heptenoate-macrolactin by means of a stepwise, decarboxylative condensation pathway established the PKS-assisted biosynthesis of the parent macrolactin and the side-chain 5-hydroxyhept-3-enoate moiety attached to the macrolactin ring system at C-7. Antimicrobial activity analysis combined with the results of amplifying genes encoding for polyketide synthetase and nonribosomal peptide synthetase showed that seaweed-associated bacteria had broad-spectrum antimicrobial activity. The present work may have an impact on the exploitation of macrolactins for pharmaceutical and biotechnological applications.

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Antibiotic Compounds from <i>Bacillus</i>: Why are they so Amazing?

Cited by 45 publications

References 54 publications

Identification and classification of known and putative antimicrobial compounds produced by a wide variety of Bacillales species

Identification and classification of known and putative antimicrobial compounds produced by a wide variety of Bacillales species

Antibiotics from neglected bacterial sources

Polyketide Family of Novel Antibacterial 7-O-Methyl-5′-hydroxy-3′-heptenoate–Macrolactin from Seaweed-Associated Bacillus subtilis MTCC 10403

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