Antibiotic-induced gut microbiota depletion from early adolescence exacerbates spatial but not recognition memory impairment in adult male C57BL/6 mice with Alzheimer-like disease

Mosaferi, Belal; Jand, Yahya; Salari, Ali-Akbar

doi:10.1016/j.brainresbull.2021.08.004

Cited by 21 publications

(12 citation statements)

References 56 publications

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“…The most common broad‐spectrum antibiotic is rifaximin, which treats diarrhea and IBS 58 . Antibiotics can diminish the variety and richness of the gut microbiota, increasing pathogenic bacteria and decreasing beneficial bacteria 59 . This dysbiosis can modify microbial metabolites including short‐chain fatty acids, which impact gut‐brain communication and neuroinflammation 26 .…”

Section: Discussionmentioning

confidence: 99%

“…Antibiotics may also collect brain beta‐amyloid plaques, which are associated with AD. Some studies show that antibiotics that target bacterial cell walls may promote beta‐amyloid plaque formation and accumulation 59 . The information on antibiotics and dementia is sparse and inconsistent 59 .…”

Section: Discussionmentioning

confidence: 99%

“…Some studies show that antibiotics that target bacterial cell walls may promote beta‐amyloid plaque formation and accumulation 59 . The information on antibiotics and dementia is sparse and inconsistent 59 . Some antibiotics may raise dementia risk, whereas others have not.…”

Section: Discussionmentioning

confidence: 99%

“…While the link between antibiotics and dementia is unclear, research shows they may harm brain health and cognitive performance. 59 Prolonged antibiotic usage can also impair cognition and increase dementia risk. 57 One study examined antibiotic exposure and dementia risk using a population-based retrospective cohort.…”

Section: Impact Of Antibiotics On Dementiamentioning

confidence: 99%

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The effects of the interplay between vitamins, antibiotics, and gut microbiota on the pathogenesis and progression of dementia: A systematic review and meta‐analysis

Prajjwal,

Inban,

Sai

et al. 2024

Health Science Reports

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BackgroundGiven that there is already evidence of a neural network that connects the brain and gut and that the gut microbiota actively modulates gut health, it is crucial to know which foods, supplements, and medications to use or avoid when treating any disease that causes dementia or cognitive impairment. Previous research has examined the relationships between vitamins, antibiotics, and gut microbiota and the correlations between these factors and dementia. The question arises of how these three factors interact together and if evidence suggests one element is more important than the others in the pathogenesis and development of dementia.MethodsThe Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) standards were followed when conducting this review. The papers' publication dates varied from (2012−2022). Cochrane/EMBASE, PEDro, and PubMed/Medline databases were searched. The precise terms “gut microbiota,” vitamins,” antibiotics,” and “dementia” were included in the search method, along with the conjunctions “OR” and “AND.”ResultsGut dysbiosis has a significant impact on cognition, brain function, and the development and progression of dementia. The two most popular probiotics used in studies linked to cognition benefits were Lactobacillus and Bifidobacterium. Numerous scales were used to evaluate cognition, but the mini‐mental state examination was the most popular, and the most prevalent impairment was Alzheimer's disease. The supplements with the most significant impact on gut microbiota were vitamin B‐12 and folic acid.ConclusionThis systematic review concluded that vitamins, gut microbiota and antibiotics have a close association with the development of dementia. More research is required to establish causality and elucidate the underlying mechanisms because there is still little evidence connecting the interactions of vitamins, medications, and microbiota with dementia. The complexity of interactions between genetics, lifestyle factors, and comorbidities, as well as the heterogeneity of dementia, may make it more challenging to interpret the findings.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Impact Of Antibiotics On Dementiamentioning

confidence: 99%

See 2 more Smart Citations

The effects of the interplay between vitamins, antibiotics, and gut microbiota on the pathogenesis and progression of dementia: A systematic review and meta‐analysis

Prajjwal,

Inban,

Sai

et al. 2024

Health Science Reports

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“…Another key target is the cytokine TNF- α , which is involved in inflammation throughout the body [ 57 ]. Furthermore, genetic and epidemiological evidence indicate that an increase in TNF- α expression is a risk factor for AD, and exacerbates A β and tau pathologies [ 58 ]. Therefore, ZNC may act on targets such as CASP3, VEGFA, MAPK1, and TNF- α to treat AD.…”

Section: Discussionmentioning

confidence: 99%

Mechanism of Zhinao Capsule in Treating Alzheimer’s Disease Based on Network Pharmacology Analysis and Molecular Docking Validation

Huang

Jiang

et al. 2022

Journal of Healthcare Engineering

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Objective. This study aimed to determine the active components of Zhinao capsule (ZNC) and the targets in treating Alzheimer’s disease (AD) so as to investigate and explore the mechanism of ZNC for AD. Methods. The active components and targets of ZNC were determined from the traditional Chinese medicine systems pharmacology database (TCMSP). The target genes of AD were searched for in GeneCards. Cytoscape was used to construct an herb-component-target-disease network. A protein-protein interaction (PPI) network was constructed by STRING. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed using the OmicShare. UCSF Chimera and SwissDock were used for molecular docking verification. Finally, four key target genes were validated by Western blotting. Results. In total, 55 active components, 287 targets of active components, 1197 disease genes, and 134 common genes were screened, which were significantly enriched in 3975 terms of biological processes (BP), 284 terms of cellular components (CC), 433 terms of molecular functions (MF), and 245 signaling pathways. Caspase-3 (CASP3) and beta-sitosterol, tumor necrosis factor-alpha (TNF-α) and quercetin, vascular endothelial growth factor A (VEGFA) and baicalein, and mitogen-activated protein kinase 1 (MAPK1) and quercetin showed good-to-better docking. Moreover, ZNC not only downregulated CASP3 and TNF-α protein expression but also upregulated the protein expression of VEGFA and MAPK1. Conclusions. The active components of ZNC, such as beta-sitosterol, quercetin, and baicalein may act on multiple targets like CASP3, VEGFA, MAPK1, and TNF-α to affect T cell receptor (TCR), TNF, and MAPK signaling pathway, thereby achieving the treatment of AD. This study provides a scientific basis for further exploring the potential mechanism of ZNC in the treatment of AD and a reference for its clinical application.

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Nanotechnology strategy for inhibition of PARP1 and IL-17A-associated with neurotoxicity in rats exposed to hospital wastewater

Sabry,

Ali,

Osman

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Hospital wastewater (HWW) poses a serious hazard to human health security concerning its high susceptibility to neurodegeneration. Water sources and ecosystems are exposed to a complicated pollution load from a variety of refractory organics and pharmaceutical active composites. This study evaluates the treated newly developed nanocomposite (NiFe2O4) HWW on the neural injury induced by HWW action in rats. Three groups of male Wistar rats were distributed, with eight rats in each: group I: tap water served as a control; group II: HWW; and group III: nano-HWW. Each group was intragastrical administrated with each type of water (2.5 ml/100 g b.wt/6 h) for 28 consecutive days. The open field test and Morris Water Maze assessed behavioral activity and spatial learning 2 days before the last day. The research demonstrated that HWW treated with nanocomposite (NiFe2O4) may exert decreased risks of the neural impairment effect of HWW. This improvement was achieved by reducing the neurotoxicity by lowering nitric oxide contents, lipid peroxidation, acetylcholinesterase, interleukin-17A (IL-17A), and poly(ADP-ribose) polymerase1(PARP1) while restoring the antioxidant biomarkers and neurotransmitter levels (β-endorphin, norepinephrine, dopamine, and serotonin) of the treated groups in the cortex and brainstem and enhancement of the histopathology of the cortex as well. In conclusion, this study introduced a newly developed nanotechnology application for treating HWW to protect from neural injury. The findings of this research have significant value for policymakers, Ministry of Health management, and environmental organizations in their selection of suitable techniques and procedures to optimize hospital wastewater treatment efficiency.

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Antibiotic-induced gut microbiota depletion from early adolescence exacerbates spatial but not recognition memory impairment in adult male C57BL/6 mice with Alzheimer-like disease

Cited by 21 publications

References 56 publications

The effects of the interplay between vitamins, antibiotics, and gut microbiota on the pathogenesis and progression of dementia: A systematic review and meta‐analysis

The effects of the interplay between vitamins, antibiotics, and gut microbiota on the pathogenesis and progression of dementia: A systematic review and meta‐analysis

Mechanism of Zhinao Capsule in Treating Alzheimer’s Disease Based on Network Pharmacology Analysis and Molecular Docking Validation

Nanotechnology strategy for inhibition of PARP1 and IL-17A-associated with neurotoxicity in rats exposed to hospital wastewater

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