2022
DOI: 10.1016/j.lfs.2022.120885
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Antibiotic-induced microbiome depletion improves LPS-induced acute lung injury via gut-lung axis

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Cited by 23 publications
(18 citation statements)
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“…According to the results, it appears that the presence of LPS has a discernible effect on the diversity and composition of the microbial population within the intestinal tract. This observation is consistent with a significant body of previous research that has also demonstrated this phenomenon [ 43 , 44 , 45 , 46 , 47 ]. LPS, which are commonly found in the cell wall of Gram-negative bacteria, have been shown to elicit significant alterations in the composition and structure of the gut microbiota.…”
Section: Discussionsupporting
confidence: 93%
“…According to the results, it appears that the presence of LPS has a discernible effect on the diversity and composition of the microbial population within the intestinal tract. This observation is consistent with a significant body of previous research that has also demonstrated this phenomenon [ 43 , 44 , 45 , 46 , 47 ]. LPS, which are commonly found in the cell wall of Gram-negative bacteria, have been shown to elicit significant alterations in the composition and structure of the gut microbiota.…”
Section: Discussionsupporting
confidence: 93%
“…We previously reported that ABX-induced depletion of the gut microbiome is associated with stress resilience in mice exposed to chronic social defeat stress ( Wang et al, 2020b ) and protects against MPTP-induced dopaminergic neurotoxicity in the brain ( Pu et al, 2019 ) and LPS (lipopolysaccharide)-induced acute lung injury ( Hashimoto et al, 2022 ). Furthermore, LPS-induced splenomegaly in mice was associated with higher levels of pro-inflammatory cytokines ( Ma et al, 2022a , 2022b ; Zhang et al, 2020b , 2021a ), suggesting that an increase in spleen weight is associated with systemic inflammation.…”
Section: Discussionmentioning
confidence: 99%
“…On days 1–14, mice were allowed ad libitum access to plain drinking water or drinking water containing the broad-spectrum antibiotic cocktail (ABX: ampicillin 1 g/L, FUJIFILM Wako Pure Chemical Corporation, Tokyo, Japan; neomycin sulfate 1 g/L, Sigma-Aldrich Co. Ltd, MO, USA; metronidazole 1 g/L, FUJIFILM Wako Pure Chemical Corporation, Tokyo, Japan) ( Fig. 1 A), as previously described ( Hashimoto et al, 2022 ; Pu et al, 2019 , 2021 ; Wang et al, 2020a , 2020b , 2021 ). Fresh mouse feces were collected on the morning of day 15 for 16S ribosomal RNA sequencing analysis as previously described ( Hashimoto et al, 2022 ; Wan et al, 2022a , 2022b ; Wang et al, 2022a , 2022b ) ( Fig.…”
Section: Methodsmentioning
confidence: 99%
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