Antibiotic-loaded chitosan-gelatin scaffolds for infected seawater immersion wound healing

Fang, Q.; Yao, Zexin; Feng, Longbao; Liu, Tian; Wei, Shikun; Xu, Pengcheng; Guo, Rui; Cheng, Biao; Wang, Xinlu

doi:10.1016/j.ijbiomac.2020.05.126

Cited by 39 publications

(22 citation statements)

References 44 publications

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“…The drug release profile was sustained with a good antibacterial effect against E. coli , P. aeruginosa, and S. aureus , in vitro and in vivo. The deposition of collagen was accelerated revealing microspheres as potential wound dressing for the treatment of bacterial-infected wounds and wounds with seawater immersion [ 125 ]. Thyagarajan et al, prepared wound dressings that will inhibit overexpression of matrix metalloproteinase, a family of endopeptidases involved in the remodelling of ECM, which is also capable of degrading ECM when over-expressed.…”

Section: Gelatin-based Hybrid Wound Dressingsmentioning

confidence: 99%

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

et al. 2021

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Wound care is a major biomedical field that is challenging due to the delayed wound healing process. Some factors are responsible for delayed wound healing such as malnutrition, poor oxygen flow, smoking, diseases (such as diabetes and cancer), microbial infections, etc. The currently used wound dressings suffer from various limitations, including poor antimicrobial activity, etc. Wound dressings that are formulated from biopolymers (e.g., cellulose, chitin, gelatin, chitosan, etc.) demonstrate interesting properties, such as good biocompatibility, non-toxicity, biodegradability, and attractive antimicrobial activity. Although biopolymer-based wound dressings display the aforementioned excellent features, they possess poor mechanical properties. Gelatin, a biopolymer has excellent biocompatibility, hemostatic property, reduced cytotoxicity, low antigenicity, and promotes cellular attachment and growth. However, it suffers from poor mechanical properties and antimicrobial activity. It is crosslinked with other polymers to enhance its mechanical properties. Furthermore, the incorporation of antimicrobial agents into gelatin-based wound dressings enhance their antimicrobial activity in vitro and in vivo. This review is focused on the development of hybrid wound dressings from a combination of gelatin and other polymers with good biological, mechanical, and physicochemical features which are appropriate for ideal wound dressings. Gelatin-based wound dressings are promising scaffolds for the treatment of infected, exuding, and bleeding wounds. This review article reports gelatin-based wound dressings which were developed between 2016 and 2021.

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Section: Gelatin-based Hybrid Wound Dressingsmentioning

confidence: 99%

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

et al. 2021

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“…Enzyme solutions, such as collagenase, lysozyme, and trypsin, were commonly used in biodegradation tests to mimic the in vivo microenvironment of matrix degradation, resulting in gradual dissolution into the supernatant. The degradation process occured due to the cleavage of intermolecular bridge between GNP and polymers by enzyme solution ( Manickam et al, 2014 ; Raja and Fathima, 2018 ; Fang et al, 2020 ).…”

Section: Genipin Crosslinking Effect On Biomatrix Propertiesmentioning

confidence: 99%

“…More than 98% of GEL was utterly degraded within 2 h, while G-Onp lasted until 3 h. Upon 12 days of in vivo experiment, they found that G-Onp-treated rat has shown more prominent collagen deposition than GEL and noncrosslinked groups. In another study, the biodegradability of GNP-crosslinked CH-GEL scaffold was studied through lysozyme degradation research by Fang et al (2020) . The degradation rate for the composite scaffolds in PBS solution without lysozyme was in the range of 15–20% after a week, 45–55% after 2 weeks, 50–60% after 3 weeks, and 60–70% after 4 weeks.…”

Section: Genipin Crosslinking Effect On Biomatrix Propertiesmentioning

confidence: 99%

Genipin-Crosslinking Effects on Biomatrix Development for Cutaneous Wound Healing: A Concise Review

Nike

Fadilah

Sallehudin

et al. 2022

Front. Bioeng. Biotechnol.

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Split skin graft (SSG), a standard gold treatment for wound healing, has numerous limitations such as lack of fresh skin to be applied, tedious process, severe scarring, and keloid formation followed by higher risks of infection. Thus, there is a gap in producing polymeric scaffolds as an alternative for wound care management. Bioscaffold is the main component in tissue engineering technology that provides porous three-dimensional (3D) microarchitecture for cells to survive. Upon skin tissue reconstruction, the 3D-porous structure ensures sufficient nutrients and gaseous diffusion and cell penetration that improves cell proliferation and vascularization for tissue regeneration. Hence, it is highly considered a promising candidate for various skin wound healing applications. To date, natural-based crosslinking agents have been extensively used to tailor the physicochemical and mechanical properties of the skin biomatrix. Genipin (GNP) is preferable to other plant-based crosslinkers due to its biological activities, such as antiinflammatory and antioxidant, which are key players to boost skin wound healing. In addition, it has shown a noncytotoxic effect and is biocompatible with human skin cells. This review validated the effects of GNP in biomatrix fabrication for skin wound healing from the last 7 years of established research articles and stipulated the biomaterial development-scale point of view. Lastly, the possible role of GNP in the skin wound healing cascade is also discussed. Through the literature output, it can be concluded that GNP has the capability to increase the stability of biomatrix and maintain the skin cells viability, which will contribute in accelerating wound healing.

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“…The mechanical properties of the materials are measured according to the test method of the pharmaceutical industry standard YY/T 0471.4-2004. 29 The tensile strength and Young's modulus were measured by an universal tester (ELF3200, U.S.) with a stretching rate of 6 mm/min. Rectangular specimens of each membrane (1 cm in width Â 7 cm length) were stretched.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Multifunctional electrospun asymmetric wettable membrane containing black phosphorus/Rg1 for enhancing infected wound healing

Zhou

Liu

Feng

et al. 2021

Bioengineering & Transla Med

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Bacterial infection is one of the most frequent complications in the burn and chronic wounds. Inspired by natural existing superhydrophobic surface structures, a novel asymmetric wettable membrane was prepared using the electrospinning technique for facilitating the bacteria‐infected wound healing. Herein, the prepared membrane consists of two layers: The hydrophobic outer layer was composed of poly (lactic‐co‐glycolic) acid (PLGA) and black phosphorus‐grafted chitosan (HACC‐BP), while the hydrophilic inner layer was composed by using a mixture of gelatin (Gel) with ginsenoside Rg1 (Rg1). Biological studies in vitro showed BP@PLGA/Gel (BP@BM) membrane with excellent antibacterial activity could significantly inhibit the adhesion of bacteria, and Rg1 could facilitate the migration and tube formation of human umbilical vein endothelial cells (HUVECs). Compared to Aquacel Ag dressing, the result in vivo revealed that the Rg1/BP@BM could facilitate better wound healing by triggering phosphoinositide 3‐kinase (P‐PI3K/PI3K) and phosphorylation of protein kinase B (P‐AKT/AKT) signaling pathways, upregulating Ki67, CD31, α‐SMA, and TGF‐β1, and downregulating TNF‐α, IL‐1β, and IL‐6, promoting M2 polarization (IL‐10, CD206, and Arg‐1) of macrophages, inhibiting M1 polarization (iNOS) of macrophages. These findings suggested that the asymmetric wettable membrane have the huge potential for wound healing.

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Antibiotic-loaded chitosan-gelatin scaffolds for infected seawater immersion wound healing

Cited by 39 publications

References 44 publications

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

Gelatin-Based Hybrid Scaffolds: Promising Wound Dressings

Genipin-Crosslinking Effects on Biomatrix Development for Cutaneous Wound Healing: A Concise Review

Multifunctional electrospun asymmetric wettable membrane containing black phosphorus/Rg1 for enhancing infected wound healing

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