2017
DOI: 10.3747/pdi.2016.00252
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Antibiotic Lock in Tenckhoff Catheter for Biofilm-Associated Peritonitis

Abstract: Biofilm bacteria in the Tenckhoff catheter are notoriously difficult to eradicate. They are the potential sources of relapsing or repeat peritonitis among peritoneal dialysis (PD) patients. Inadequate penetration into biofilms by standard intraperitoneal antibiotics, as well as a lack of effective adjunctive treatment, leads to a high rate of Tenckhoff catheter loss as a result of biofilm bacteria. In hemodialysis, on the other hand, catheter-related bloodstream infection caused by biofilm bacteria does not ne… Show more

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Cited by 6 publications
(5 citation statements)
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“…Antibiotic lock, which comprises highly-concentrated antibiotic, is a proven adjunctive treatment for hemodialysis catheter infection. In our institution, we have experienced consistent positive results with the use of antibiotic lock for the removal of biofilm bacteria on Tenckhoff catheters (6). Indeed, PD is a unique form of renal replacement therapy and we need to address several issues that are specific to PD when we consider antibiotic lock as an adjunctive treatment for biofilm-associated PD peritonitis.…”
Section: Discussionmentioning
confidence: 68%
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“…Antibiotic lock, which comprises highly-concentrated antibiotic, is a proven adjunctive treatment for hemodialysis catheter infection. In our institution, we have experienced consistent positive results with the use of antibiotic lock for the removal of biofilm bacteria on Tenckhoff catheters (6). Indeed, PD is a unique form of renal replacement therapy and we need to address several issues that are specific to PD when we consider antibiotic lock as an adjunctive treatment for biofilm-associated PD peritonitis.…”
Section: Discussionmentioning
confidence: 68%
“…To conclude, we have reported another patient suffering from problematic biofilm-associated PD peritonitis who was successfully treated by antibiotic lock in the Tenckhoff catheter. In addition to our previous report (6), we have provided more data about the need to suspend PD during the dwell of antibiotic lock, as well as the optimal dwell time that can maintain its effectiveness with minimal interruption in the usual PD schedule. However, given the potential confounding effect of PD suspension on our success of biofilm bacteria eradication, further clinical trials are necessary to confirm the benefits of antibiotic-lock treatment.…”
Section: Discussionmentioning
confidence: 97%
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“…Using the adequate antibacterial regimens and compliance with developed protocols, most episodes of the GP rapidly regress, allowing successful dialysis. However, repeated episodes of DP, associated with the lack of rehabilitation of infectious cells (usually nasal) or permanent re-infection of the abdominal cavity due to violations of the technique of the procedure, can cause the termination of CAPD [16]. In circumstance of persistent infection, it's necessary to eliminate peritonitis, remove the catheter and switch to the HD, with the continuation of antibacterial therapy until the signs of the infectious and inflammatory process completely disappear [17].…”
mentioning
confidence: 99%