Antibiotic Management of Uncomplicated Skin and Soft Tissue Infections in the Real World

Abstract

Background: Skin and soft tissue infections are one of the main causes of consultations worldwide. The objective was to determine the treatment of a group of patients with uncomplicated skin and soft tissue infections in Colombia. Methods: Follow-up study of a cohort of patients with skin infections who were treated in the Colombian Health System. Sociodemographic, clinical and pharmacological variables were identified. Treatments were evaluated using clinical practice guidelines for skin infections. Results: A total of 400 patients were analyzed. They had a median age of 38.0 years and 52.3% were men. The most commonly used antibiotics were cephalexin (39.0%), dicloxacillin (28.0%) and clindamycin (18.0%). A total of 49.8% of the subjects received inappropriate antibiotics, especially those with purulent infections (82.0%). Being cared for in an outpatient clinic (OR: 2.09; 95% CI: 1.06–4.12), presenting pain (OR: 3.72; 95% CI: 1.41–9.78) and having a purulent infection (OR: 25.71; 95% CI: 14.52–45.52) were associated with a higher probability of receiving inappropriate antibiotics. Conclusions: Half of patients with uncomplicated skin and soft tissue infections were treated with antibiotics that were not recommended by clinical practice guidelines. This inappropriate use of antibiotics occurred in the vast majority of patients with purulent infections because the antimicrobials used had no effect on methicillin-resistant Staphylococcus aureus.

Clinical characteristics and use of antibiotics in a group of patients with snake bites in Colombia

“…However, it is common in the literature to find resistance to first-and second-generation cephalosporins, aminopenicillins with beta-lactamase inhibitors, and oxacillin, among others. [14][15][16] In Colombia, the use of antibiotics for unapproved indications is common, [29][30][31] a condition that leads to adverse clinical (increased length of hospital stay, morbidity, mortality, and antimicrobial resistance) and economic (increased costs of care) effects. 32 Thus, it is important to highlight that, in this study, the inappropriate use of antibiotics prevailed in most patients.…”

Formulation and characterization of antibiotic drug loaded aquasome for the topical application

“…Accumulating evidences indicates that the antibiotics used against the skin and soft tissue infections are also becoming resistant and thus it has to be properly addressed [ 17 , 18 ]. Instead of looking for new antibiotics development which consumes time and requires huge amount of funds, the existing antibiotics can be delivered specially to the site of infection with controlled release manner [ 19 ]. Aquasomes are 3-layered vesicular nano carriers used to specially delivery the drugs to the site of target which has been used in various diseases such as cancer, cardiovascular diseases and infections [ 20 , 21 ].…”