Antibiotic-Modifying Activity and Chemical Profile of the Essential Oil from the Leaves of<i>Cordia verbenacea</i>DC.

Carvalho, Victória Regina de Alencar; Silva, Maria Karollyna do Nascimento; Aguiar, José Júnior; Bitu, Vanessa de Carvalho Nilo; Costa, José Galberto Martins da; Ribeiro-Filho, Jaime; Coutinho, Henrique Douglas Melo; Pinho, Antônio Ivanildo; Matias, Edinardo Fágner Ferreira

doi:10.1080/0972060x.2017.1301220

Cited by 8 publications

(3 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Still, in relation to the essential oil from C. verbenaea , some studies have been conducted relating its action to anti-trypanocidal and anti- Leishmania [ 63 ]. The class of compounds present in the greatest quantity are hydrocarbon monoterpenes, followed hydrocarbon sesquiterpenes, which is consistent with previous findings [ 44 ]. Regarding the compound Tricyclo 2.2.1 (2,6) heptane, this is the first report of its presence in this species.…”

Section: Discussionsupporting

confidence: 93%

“…The α-pinene, α-santalene and (E)-cariophyllene are the representative compounds present in the essential oil of C. verbenaceae [ 43 , 44 ]. The economic and pharmacological potential of this essential oil is due to the production of the chemical markers β-caryophyllene and α-humulene [ 40 ], which are associated with cytotoxicity and antiproliferative, pro-apoptotic and antitumor activities [ 45 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cytotoxicity of Essential Oil Cordia verbenaceae against Leishmania brasiliensis and Trypanosoma cruzi

et al. 2021

View full text Add to dashboard Cite

The species Cordia verbenacea DC (Boraginaceae), known as the whaling herb and camaradinha, is a perennial shrub species native to the Atlantic Forest. Its leaves are used in folk medicine as an anti-inflammatory, analgesic, antiulcerogenic and curative agent, in the form of teas or infusions for internal or topical use. The present study aimed to verify the cytotoxicity of the essential oil and the leishmanicidal and trypanocidal potential of C. verbenacea. The essential oil was characterized by GC-MS. The in vitro biological activity was determined by anti-Leishmania and anti-Trypanosoma assays. The cytotoxixity was determined using mammalian fibroblasts. The C. verbenacea species presented α-pinene (45.71%), β-caryophyllene (18.77%), tricyclo[2,2,1-(2.6)]heptane (12.56%) as their main compounds. The essential oil exhibited strong cytotoxicity at concentrations below 250 μg/mL (LC50 138.1 μg/mL) in mammalian fibroblasts. The potent anti-trypanosome and anti-promastigote activities occurred from the concentration of 62.5 μg/mL and was considered clinically relevant. The results also demonstrate that at low concentrations (<62.5 μg/mL), the essential oil of C. verbenacea managed to be lethal for these activities. This can be considered an indication of the power used in daily human consumption. Therefore, it can be concluded that the essential oil of C. verbenacea contains a compound with remarkable antiparasitic activities and requires further research.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of Essential Oil Cordia verbenaceae against Leishmania brasiliensis and Trypanosoma cruzi

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Cordia alliodora Cham., one of the most important timber trees in the Amazon, has an interesting chemical profile [5,6,7,8,9,10,11] with antimicrobial, antifungal, larvicidal [12] and cytotoxic activities [13] which have been experimentally tested. Cordia verbenaceae DC has been studied as anti-inflammatory [14], analgesic [15], antibacterial [16], antiallergic [17] and antitumoral [18]; the latter activity is attributed to the rosmarinic acid (Figure 1) [19].…”

Section: Introductionmentioning

confidence: 99%

In Silico Molecular Studies of Antiophidic Properties of the Amazonian Tree Cordia nodosa Lam.

et al. 2019

View full text Add to dashboard Cite

We carried out surveys on the use of Cordia nodosa Lam. in the jungles of Bobonaza (Ecuador). We documented this knowledge to prevent its loss under the Framework of the Convention on Biological Diversity and the Nagoya Protocol. We conducted bibliographic research and identified quercetrin as a significant bioactive molecule. We studied its in silico biological activity. The selected methodology was virtual docking experiments with the proteins responsible for the venomous action of snakes. The molecular structures of quercetrin and 21 selected toxins underwent corresponding tests with SwissDock and Chimera software. The results point to support its antiophidic use. They show reasonable geometries and a binding free energy of −7 to −10.03 kcal/mol. The most favorable values were obtained for the venom of the Asian snake Naja atra (5Z2G, −10.03 kcal/mol). Good results were also obtained from the venom of the Latin American Bothrops pirajai (3CYL, −9.71 kcal/mol) and that of Ecuadorian Bothrops asper snakes (5TFV, −9.47 kcal/mol) and Bothrops atrox (5TS5, −9.49 kcal/mol). In the 5Z2G and 5TS5 L-amino acid oxidases, quercetrin binds in a pocket adjacent to the FAD cofactor, while in the myotoxic homologues of PLA2, 3CYL and 5TFV, it joins in the hydrophobic channel formed when oligomerizing, in the first one similar to α-tocopherol. This study presents a case demonstration of the potential of bioinformatic tools in the validation process of ethnobotanical phytopharmaceuticals and how in silico methods are becoming increasingly useful for sustainable drug discovery.

show abstract

Chemodiversity and Trypanocidal Activity of the Volatile Oils of Tropical Black Sage

de Medeiros,

Nascimento,

Duarte Junior

et al. 2024

Rev. Bras. Farmacogn.

View full text Add to dashboard Cite

Antibiotic-Modifying Activity and Chemical Profile of the Essential Oil from the Leaves ofCordia verbenaceaDC.

Cited by 8 publications

References 40 publications

Cytotoxicity of Essential Oil Cordia verbenaceae against Leishmania brasiliensis and Trypanosoma cruzi

Cytotoxicity of Essential Oil Cordia verbenaceae against Leishmania brasiliensis and Trypanosoma cruzi

In Silico Molecular Studies of Antiophidic Properties of the Amazonian Tree Cordia nodosa Lam.

Chemodiversity and Trypanocidal Activity of the Volatile Oils of Tropical Black Sage

Contact Info

Product

Resources

About