“…This is especially important as there is no perceived clinical benefit from the use of antibiotics in the treatment of URTIs in many patients, including those with a common cold or persistent acute purulent rhinitis, with evidence of significant adverse events in adults from antibiotics 21,27,85,228 . Despite this lack of benefit, considerable prescribing and dispensing of antibiotics still occurs for patients with URTIs especially in LMICs 21,87,88,92,120,209,227,229,230 , although rates vary appreciably across countries. For example, Holloway et al found in their recent review that the rates of treating URTIs inappropriately in children in LMICs were high, with the use of antibiotics ranging from 42-72% of patients 97 , and Ahiabu et al found that 86.4% of patients with URTIs attending primary healthcare facilities in Ghana were prescribed an antibiotic 231 .…”