Antibiotic Prophylaxis in an Animal Model of Chronic Peritoneal Exposure

Choi, Jaehwa; Credit, Kimberly; Henderson, Kristi; Deverkadra, Ravi; Vanpelt, H; He, Zhi; Flessner, Michael F.

doi:10.1177/089686080602600222

Cited by 12 publications

(11 citation statements)

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“…Therefore, some authors opt for routine addition of antibiotics. 25,26 Such an approach was used in 103 studies. The most common antibiotic was gentamicin (45%; 46 of 103), and more than one antibiotic was used in 63% (65 of 103) of studies.…”

Section: Resultsmentioning

confidence: 99%

Quality of design and reporting of animal research in peritoneal dialysis: A scoping review

et al. 2020

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The concerns about reproducibility and validity of animal studies are partly related to poor experimental design and reporting. Here, we undertook a scoping review of the literature to determine the extent and quality of reporting of animal studies on peritoneal dialysis (PD). Online databases were searched to identify 567 relevant original articles published between 1979 and 2018. These were analyzed with respect to bibliographic parameters and general aspects of animal experimentation. A subgroup of 120 studies was analyzed in detail in terms of the impact on the reporting quality of the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines for animal studies. The number of animal studies on PD increased continuously over the years with a thematic shift toward long-term preservation of the peritoneum as a dialyzing organ. There were significant deficiencies in research design with the lack of sample size estimation, randomization, and blinding being the commonest shortcomings. The description of animal numbers, housing conditions, use of medication, and statistical analysis was incomplete. The introduction in 2010 of the ARRIVE guidelines produced very little improvement in the completeness of reporting regardless of journal impact factor. The animal studies on PD suffer from deficits in experimental protocols and transparent reporting. These drawbacks need to be corrected to ensure high-quality and much-needed animal research in PD.

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Section: Resultsmentioning

confidence: 99%

Quality of design and reporting of animal research in peritoneal dialysis: A scoping review

et al. 2020

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“…PD should be restarted after the infection is treated. In severe cases, it may be necessary to arrange for catheter replacement or even PD termination ( 53 ).…”

Section: Potential Complications In the Preparation Of A Pd Modelmentioning

confidence: 99%

Experimental models in peritoneal dialysis (Review)

et al. 2021

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Peritoneal dialysis (PD) is one of the most commonly used dialysis methods and plays an important role in maintaining the quality of life of patients with end-stage renal disease. However, long-term PD treatment is associated with adverse effects on the structure and function of peritoneal tissue, which may lead to peritoneal ultrafiltration failure, resulting in dialysis failure and eventually PD withdrawal. In order to prevent the occurrence of these effects, the important issues that need to be tackled are improvement of ultrafiltration, protection of peritoneal function and extension of dialysis time. In basic PD research, a reasonable experimental model is key to the smooth progress of experiments. A good PD model should not only simulate the process of human PD as accurately as possible, but also help researchers to understand the evolution process and pathogenesis of various complications related to PD treatment. To better promote the clinical application of PD technology, the present review will summarize and evaluate the in vivo PD experimental models available, thus providing a reference for relevant PD research.

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“…The size of nanoparticles has a substantial effect on endocytosis in cancer cells. An appropriate size helps promote the accumulation of drugs in the tumor, inappropriate size being counterproductive (Zutter et al., 1998 ; Choi et al., 2006 ; Wong et al., 2011 ). Studies have shown that the particle sizes of polymer micelles after drug loading is larger than those that are unloaded, so that the entire drug loading system requires careful consideration (Shuai et al., 2004a , 2004b ; Elhasi et al., 2007 ).…”

Section: Strategies For Promoting Penetration Of Nano-drugsmentioning

confidence: 99%

Recent advances in drug delivery systems for enhancing drug penetration into tumors

Sui

et al. 2020

Drug Delivery

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The emergence of nanomaterials for drug delivery provides the opportunity to avoid the side effects of systemic drug administration and injury caused by the removal of tumors, delivering great promise for future cancer treatments. However, the efficacy of current nano drugs is not significantly better than that of the original drug treatments. The important reason is that nano drugs enter the tumor vasculature, remaining close to the blood vessels and unable to enter the tumor tissue or tumor cells to complete the drug delivery process. The low efficiency of drug penetration into tumors has become a bottleneck restricting the development of nano-drugs. Herein, we present a systematic overview of recent advances on the design of nano-drug carriers in drug delivery systems for enhancing drug penetration into tumors. The review is organized into four sections: The drug penetration process in tumor tissue includes paracellular and transcellular transport, which is summarized first. Strategies that promote tumor penetration are then introduced, including methods of remodeling the tumor microenvironment, charge inversion, dimensional change, and surface modification of ligands which promote tissue penetration. Conclusion and the prospects for the future development of drug penetration are finally briefly illustrated. The review is intended to provide thoughts for effective treatment of cancer by summarizing strategies for promoting the endocytosis of nano drugs into tumor cells.

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Antibiotic Prophylaxis in an Animal Model of Chronic Peritoneal Exposure

Cited by 12 publications

References 40 publications

Quality of design and reporting of animal research in peritoneal dialysis: A scoping review

Quality of design and reporting of animal research in peritoneal dialysis: A scoping review

Experimental models in peritoneal dialysis (Review)

Recent advances in drug delivery systems for enhancing drug penetration into tumors

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