Antibiotic prophylaxis in gastrointestinal endoscopy

Ishaq, Savid; Lipp, Allyson

doi:10.1136/gut.2010.210450

Cited by 2 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, prophylactic antibiotic treatment prior to ERCP is not routinely recommended. However, it is required when there is a need of repeated biliary interventions to achieve adequate biliary decompressions [22,24].…”

Section: Discussionmentioning

confidence: 99%

Microbial profile of biliary tract infection in patients undergoing therapeutic endoscopic retrograde cholangiopancreatography (ERCP), and baseline risk factors predicting microbial growth and post-ERCP cholangitis

Ismail,

Khan,

Laeeq

et al. 2024

View full text Add to dashboard Cite

Introduction: Stasis of bile flow can result in microbial colonization of the biliary tree. Cholangitis is a common adverse event linked to endoscopic retrograde cholangiopancreatography (ERCP).Aim: To establish the bacterial profiles isolated from the bile sample and to evaluate the pre-ERCP risk factors predicting the microbial growth and development of post-ERCP cholangitis (PEC).Material and methods: This was a prospective cohort study, which was conducted at the Department of Hepato-gastroenterology, SIUT from 1 January 2021 to 31 December 2021. Patients of either gender undergoing index ERCP procedure were included in the study. All the patients underwent ERCP, and bile culture (BC) aspirated immediately after cannulation was achieved prior to the contrast injection. There were 2 outcome variables. One was the presence or absence of organisms in bile culture, and the second one was the development of PEC.Results: The total number of patients was 280. Bile culture was positive in 195 (69.6%) patients, and post-ERCP cholangitis developed in 187 (66.8%) patients. The most common organism in BC was Escherichia coli (E. coli), in 82 (42%) patients. History of jaundice, abdominal pain, and weight loss on admission along with ERCP performed for common bile duct (CBD) stricture were independent predictors of positive BC and PEC, while advanced age was an additional risk factor for PEC.Conclusions: Microbial profile and risk factors for positive BC and PEC were evaluated. Advanced age, pre-operative jaundice, and prolonged biliary stasis are the independent risk factors for these conditions. and baseline risk factors predicting microbial growth and post-ERCP cholangitis Gastroenterology Review 2024; 19 Table V. Univariate analysis for risk factors for post-ERCP cholangitis Variable Post-ERCP cholangitis P-value Present Absent Age [years] mean ± SD 47.8 ±12 45.3 ±14 0.171 Age stratification < 45 years 77 49 0.034 ≥ 45 years 110 44 Gender Male 96 49 0.348 Female 91 44

show abstract

Section: Discussionmentioning

confidence: 99%

Microbial profile of biliary tract infection in patients undergoing therapeutic endoscopic retrograde cholangiopancreatography (ERCP), and baseline risk factors predicting microbial growth and post-ERCP cholangitis

Ismail,

Khan,

Laeeq

et al. 2024

View full text Add to dashboard Cite

show abstract

“…The use of prophylactic antibiotics before the ERCP procedure is not routinely required, according to the guidelines updated by the Digestive Endoscopy Branch of British Society of Digestion (BSG) in June 2009. A full antibiotic course is required when the treatment is aimed at achieving adequate biliary decompression by repeat interventions [34]. Currently, the third-generation cephalosporins or penicillin/ β -lactamase inhibitors are recommended as the empirical treatment for biliary infections [35].…”

Section: Discussionmentioning

confidence: 99%

Microbial Profiles and Risk Factors of Preexisting Biliary Infection in Patients with Therapeutic Endoscopy

Ruan

Liao

Peng

et al. 2019

Gastroenterology Research and Practice

View full text Add to dashboard Cite

Background. The bile infection may already exist before the administration of an interventional procedure, despite no clinical manifestations of cholangitis detected. Blood cultures remained negative even in more than half of the febrile cases with cholangitis. Risk factors associated with bacterial growth in bile before the intervention are not well defined. To establish the bacterial profiles isolated from the bile samples and to identify risk factors for bacterial colonization in the bile system. Methods. Individuals who underwent endoscopic retrograde cholangiopancreatography (ERCP) interventions were enrolled. Bile samples were aspirated and were immediately transferred into a sterile tube for storage. Results. Positive bile cultures were detected in 363 (38.0%) of 956 patients, including 322 benign diseases and 41 malignances. Of 363 positive cases, 351 (96.7%) were monoinfection and 12 (3.3%) multi-infection. Escherichia coli were the most common Gram-negative bacteria (210, 56.0%), followed by Klebsiella pneumoniae (45, 12.0%). Enterococcus faecalis represented the most common Gram-positive microorganism (19, 5.07%), while Candida albicans (11, 2.93%) were the dominant fungi. Klebsiella pneumoniae were more frequently detected in malignant diseases (P=0.046). Age, previous ERCP history or OLT history, and CBD diameter were independent risk factors for positive cultures (P<0.05) while preoperative jaundice drug therapy was the protective factor for bile infection (P<0.05). Conclusion. Monomicrobial infection was dominant among all infections, and Klebsiella pneumoniae strains were more frequently isolated from patients with malignant diseases. To effectively manage patients who are at a high risk for bile infection, a detailed diagnosis and treatment plan for each case should be prepared.

show abstract

Antibiotic prophylaxis in gastrointestinal endoscopy

Cited by 2 publications

References 6 publications

Microbial profile of biliary tract infection in patients undergoing therapeutic endoscopic retrograde cholangiopancreatography (ERCP), and baseline risk factors predicting microbial growth and post-ERCP cholangitis

Microbial profile of biliary tract infection in patients undergoing therapeutic endoscopic retrograde cholangiopancreatography (ERCP), and baseline risk factors predicting microbial growth and post-ERCP cholangitis

Microbial Profiles and Risk Factors of Preexisting Biliary Infection in Patients with Therapeutic Endoscopy

Contact Info

Product

Resources

About