2013
DOI: 10.1128/aac.00711-13
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Antibiotic Reduction Campaigns Do Not Necessarily Decrease Bacterial Resistance: the Example of Methicillin-Resistant Staphylococcus aureus

Abstract: iInterventions designed to reduce antibiotic consumption are under way worldwide. While overall reductions are often achieved, their impact on the selection of antibiotic-resistant selection cannot be assessed accurately from currently available data. We developed a mathematical model of methicillin-sensitive and methicillin-resistant Staphylococcus aureus (MSSA and MRSA) transmission inside and outside the hospital. A systematic simulation study was then conducted with two objectives: to assess the impact of … Show more

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Cited by 24 publications
(34 citation statements)
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“…[15][16][17][18] Overall, 68 publications were included and reviewed in detail. 10,14,[34][35][36][37][38][39][40][41][42][43][44][45][46]49,50,[52][53][54][55][56][85][86][87][88][89][101][102][103][104][105][106][107][108][109][110][111][112][113][114][115] Causative organisms modeled Almost one-half of the included studies investigated the dynamics of methicillin-resistant Staphylococcus aureus (MRSA) in a health care setting (47%, 38 studies), followed by vancomycin-resistant Enterococci (VRE) and Clostridium difficile (CD), with significantly fewer studies (12%, 10 studies and 7%, 6 studies, respectively). Other pathogens have rarely been the subject of interest for studies in this field.…”
Section: Data Itemsmentioning
confidence: 99%
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“…[15][16][17][18] Overall, 68 publications were included and reviewed in detail. 10,14,[34][35][36][37][38][39][40][41][42][43][44][45][46]49,50,[52][53][54][55][56][85][86][87][88][89][101][102][103][104][105][106][107][108][109][110][111][112][113][114][115] Causative organisms modeled Almost one-half of the included studies investigated the dynamics of methicillin-resistant Staphylococcus aureus (MRSA) in a health care setting (47%, 38 studies), followed by vancomycin-resistant Enterococci (VRE) and Clostridium difficile (CD), with significantly fewer studies (12%, 10 studies and 7%, 6 studies, respectively). Other pathogens have rarely been the subject of interest for studies in this field.…”
Section: Data Itemsmentioning
confidence: 99%
“…37 Thirteen percent of the included studies (9 studies) adopted hybrid models, which combined 2 types of simulation modeling. [37][38][39][40][41][42][43][44][45] Based on a toolkit of designs for hybridizing 2 types of simulation modeling proposed by Morgan and colleagues, 23 we identified that 6 studies mixed ABM and SD models using either the enrichment, 38 interaction, 39 or integration 40,44,45 approach. Two studies adopted a sequential design to combine SD and DES, 42,43 and one study used a SD model and a stochastic continuous time Markov chain model in a parallel design.…”
Section: Model Hybridizationmentioning
confidence: 99%
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