Antibiotic Residues in Food and Drinking Water, and Food Safety Regulations

Greenlees, Kevin J.; Friedlander, Lynn G.; Boxall, Alistair B.A.

doi:10.1002/9781118067208.ch3

Cited by 8 publications

(5 citation statements)

References 46 publications

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“…Currently, hundreds of substances are used as growth enhancers, prophylaxis, and treatment for diseases in food-producing animals. 1 , 2 Antibiotics are among the most widely used veterinary drugs for therapeutic purposes. 3 Among the veterinary antibiotics, tetracyclines (TCs) are antibacterial substances that are commonly used in both human and veterinary practices.…”

Section: Introductionmentioning

confidence: 99%

Determination of Tetracycline Residues in Kidney and Muscle of Beef Cattle Slaughtered in Dire Dawa and Harar Municipal Abattoirs, Eastern Ethiopia

Mohammed¹,

Mengistu

Abdurehman

et al. 2022

Environ�Health�Insights

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Background: Antibiotics are among the most widely used drugs in farm animals for therapeutic and prophylactic purposes. However, the antibiotic residues in meat are a serious public health concern due to their harmful effects on consumer health. Besides this problem, there is limited information on the level of the antibiotic residues, including tetracycline residues. Therefore, this study was aimed to determine the tetracycline residues in the kidney and muscle samples of beef cattle in Harar town and Dire Dawa city. Methods: A study was conducted on 500 randomly selected carcass (250 kidney and 250 muscle samples) slaughtered at Dire Dawa and Harar municipal slaughterhouses between December 2018 and December 2019. The samples were collected aseptically and screened for tetracycline residues by thin layer chromatography. Then, presumptive positive samples were analyzed using high-performance liquid chromatography to get a quantitative outcome. Descriptive statistics were used to determine the frequency, mean, or standard deviation to determine the summary values and distribution of the outcomes. Finally, the data was analyzed using SPSS version 21 software. Results: Out of 500 samples, oxytetracycline residues were detected in 84% of the samples. However, tetracycline and doxycycline were not detected in all samples. Among the kidney and muscle samples collected from Dire Dawa and Harar abattoirs, 109 (87.2%) and 101 (80.8%) were positive for oxytetracycline, respectively. Oxytetracycline residue levels in Dire Dawa ranged from 57 to 607 µg/kg for the kidney and 10.14 to 435 µg/kg for muscle samples. Among the samples collected from Harar, the concentration of oxytetracycline residues ranged from 16 to 433 µg/kg and 6 to 435 µg/kg for kidney and muscle samples, respectively, at Harar slaughterhouses. About 22.0% of muscle samples collected from Dire Dawa and 17.8% from Harar town had oxytetracycline residues above maximum residue limits. Conclusions: In general, the study revealed that oxytetracycline residues were prevalent among tetracycline residues analyzed from kidney and muscle samples in the study areas. Thus, there is a risk of consumer exposure to these antibiotic residues that may have human health effects. Therefore, awareness creation and strict regulation is needed by the regulatory authorities for the use of antimicrobial drugs in the livestock industry.

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Section: Introductionmentioning

confidence: 99%

Determination of Tetracycline Residues in Kidney and Muscle of Beef Cattle Slaughtered in Dire Dawa and Harar Municipal Abattoirs, Eastern Ethiopia

Mohammed¹,

Mengistu

Abdurehman

et al. 2022

Environ�Health�Insights

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“…Antibiotics are used regularly for the treatment of diseases in animals. Additionally, they are applied to animals for enhancing feed efficiency and growth rate (Greenless et al, 2012). Residues can occur in the edible tissues of the animals due to antibiotic usage in food producing animals.…”

Section: Introductionmentioning

confidence: 99%

Multiresidue method for the simultaneous analysis of antibiotics and mycotoxins in feeds by ultra-high performance liquid chromatography coupled to tandem mass spectrometry

Konak

Yatmaz

Nilüfer

et al. 2021

AAlim

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Residues in animal feeds and foods of animal origin have been important safety issue concerning both human and animal health. A multiresidue method for determination of eight mycotoxins and ten antibiotics was developed and validated in animal feeds by using QuEChERS (quick, easy, cheap, effective, rugged, and safe) extraction followed by UHPLC-MS/MS. Optimisation of UHPLC-MS/MS parameters was performed to achieve good separation and resolution. The method was validated according to the European Commission Decision 2002/657/EC. Matrix matched calibration curves showed good r2 (≥0.995) values, and limit of quantification (LOQ) values varied between 1.2 and 5.2 μg kg−1. Average recoveries ranged from 60 to 102% with relative standard deviations of 2.2 and 15.6% for all type of feed samples except for tetracyclines, lincomycin, tylosin, ochratoxin A, and fumonisin (B1 and B2).

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“…When contaminated soil and water are used for agricultural production, potential risks of pharmaceuticals to food safety and human health need to be examined in terms of chronic low-level exposure and the proliferation of antibiotic resistant bacteria and genes. 9,11,12 Currently over 70% of the world's freshwater is used for crop irrigation. 13,14 Due to increasing water shortage, alternative irrigation water sources (often of lower water quality) must be considered.…”

Section: ■ Introductionmentioning

confidence: 99%

“…For instance, as an important group of pharmaceuticals, antibiotics are commonly used in livestock production for growth promotion and disease prevention and treatment. , Like many other pharmaceuticals, a significant portion of the administered antibiotics is released to agroecosystems via sewage sludge, wastewater effluents, animal manure, and agricultural wastewater, due to incomplete drug metabolism or insufficient removal during wastewater treatment. ,− The anthropogenic loading of antibiotics to agroecosystems has been linked to the proliferation of antibiotic resistance in bacteria populations. ,, Antibiotic resistance is an eminent global health threat, thus demanding more research in both clinical and agricultural settings. When contaminated soil and water are used for agricultural production, potential risks of pharmaceuticals to food safety and human health need to be examined in terms of chronic low-level exposure and the proliferation of antibiotic resistant bacteria and genes. ,, …”

Section: Introductionmentioning

confidence: 99%

Uptake and Accumulation of Pharmaceuticals in Overhead- and Surface-Irrigated Greenhouse Lettuce

Bhalsod

Chuang²,

Jeon

et al. 2018

J. Agric. Food Chem.

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Understanding the uptake and accumulation of pharmaceuticals in vegetables under typical irrigation practices is critical to risk assessment of crop irrigation with reclaimed water. This study investigated the pharmaceutical residues in greenhouse lettuce under overhead and soil-surface irrigations using pharmaceutical-contaminated water. Compared to soil-surface irrigation, overhead irrigation substantially increased the pharmaceutical residues in lettuce shoots. The increased residue levels persisted even after washing for trimethoprim, monensin sodium, and tylosin, indicating their strong sorption to the shoots. The postwashing concentrations in fresh shoots varied from 0.05 ± 0.04 μg/kg for sulfadiazine to 345 ± 139 μg/kg for carbamazepine. Root concentration factors ranged from 0.04 ± 0.14 for tylosin to 19.2 ± 15.7 for sulfamethoxazole. Translocation factors in surface-irrigated lettuce were low for sulfamethoxalzole, trimethoprim, monensin sodium, and tylosin (0.07-0.15), but high for caffeine (4.28 ± 3.01) and carbamazepine (8.15 ± 2.87). Carbamazepine was persistent in soil and hyperaccumulated in shoots.

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Antibiotic Residues in Food and Drinking Water, and Food Safety Regulations

Cited by 8 publications

References 46 publications

Determination of Tetracycline Residues in Kidney and Muscle of Beef Cattle Slaughtered in Dire Dawa and Harar Municipal Abattoirs, Eastern Ethiopia

Determination of Tetracycline Residues in Kidney and Muscle of Beef Cattle Slaughtered in Dire Dawa and Harar Municipal Abattoirs, Eastern Ethiopia

Multiresidue method for the simultaneous analysis of antibiotics and mycotoxins in feeds by ultra-high performance liquid chromatography coupled to tandem mass spectrometry

Uptake and Accumulation of Pharmaceuticals in Overhead- and Surface-Irrigated Greenhouse Lettuce

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