Antibiotic Resistance among <i>Escherichia coli</i> O‐serotypes from the Gut and Carcasses of Commercially Slaughtered Broiler Chickens: a Potential Public Health Hazard

Linton, A. H.; Howe, Katherine; Hartley, Christine L.; Clements, Helen M.; Richmond, M. H.; Osborne, A. D.

doi:10.1111/j.1365-2672.1977.tb00704.x

Cited by 40 publications

(13 citation statements)

References 27 publications

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“…Drug-resistant E. coli were shown to comprise a variable percentage of the total fecal coliform population, rang- Irrespective of the source ofthe selection pressure, the fact remains that healthy household dogs may excrete very high numbers of multiresistant, R-plasmid-carrying E. coli. Since the E. coli serotypes of humans and animals are indistinguishable (4,7,11), R-factor-carrying E. coli may be transferred from domestic pets to family members. During colonization of the intestinal tract of human contacts, the possibility of R-factor transfer to the resident human enteric flora cannot be discounted.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic resistance and R-factors in the fecal coliform flora of urban and rural dogs

Monaghan¹,

Tierney²,

Colleran³

1981

Antimicrob Agents Chemother

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The incidence of antibiotic-resistant fecal coliforms in the rectal flora of 106 healthy dogs in the Galway area was investigated. As far as could be determined, none of the dogs had received antimicrobial drugs. Half of the dogs sampled were from homes within the city boundaries, whereas the remainder were from farms within a 40-mile (24.8-km) radius of the city. Of the dogs sampled, 47 had a highly susceptible fecal coliform flora, with less than 1% of the coliform population resistant to any of the four test antibiotics. Fecal coliforms resistant to one or more of the test drugs comprised between 40 and 100% of the total fecal coliform population of 36% of the rural dogs and 13% of the urban dogs sampled. Of the 473 resistant Escherichia coli isolates studied, the highest number of associated resistance determinants encountered was 5, with a median number of 2.5. Of the E. coli isolates from rural dogs, 52% were resistant to three or more antibiotics compared with 37% of the isolates from urban dogs. A total of 64% of the isolates were shown to transfer some or all oftheir resistance determinants by conjugation. The transferability of ampicillin (77%) and chloramphenicol (70%) resistance determinants was higher than that of streptomycin (40%) or tetracycline (44%).

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Section: Discussionmentioning

confidence: 99%

Antibiotic resistance and R-factors in the fecal coliform flora of urban and rural dogs

Monaghan¹,

Tierney²,

Colleran³

1981

Antimicrob Agents Chemother

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“…Such non-therapeutic uses have been of major concern to those engaged in the treatment of infectious diseases, especially as a correlation has been found between the widespread use of antimicrobial drugs and the emergence of drug resistance (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Thus, resistance patterns of animal E. coli isolates have been found to be similar to those found among the isolates from humans who were closely associated with the animals (7,14,(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Direct transmission of Escherichia coli from poultry to humans

Ojeniyi

1989

Epidemiol. Infect.

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SUMMARYEight hundred and sixty-four Escherichia coli isolates from workers at the University of Ibadan Teaching and Research Poultry Farm, and 216 isolates from poultry attendants at a commercial poultry farm in the city were found to be resistant to streptomycin, sulphafurazole and tetracycline. In contrast, all 576 and 288 E. coli isolates from village fowls and from villagers respectively were sensitive to these drugs. Isolates from birds in a modern university poultry unit (3744) exhibited the same resistance patterns as those isolated from workers who were in direct contact with the birds. No nalidixic acid-resistant E. coli was isolated from farm workers prior to their assignment to the experimental pen. Following experimental oral infection of birds with E. coli K12 J5 NA Lac, the organism was recovered from the workers who manned the experimental pen. Neither before nor after the experimental infection was any nalidixic acid resistant E. coli isolated from workers who manned the pen from which birds used in the experiment were selected. Similarly, no drug resistant organisms were isolated from workers outside the poultry unit of the university or commercial farm. The MIC of the drugs against the avian and human E. coli isolates at the university and commercial poultry farms were similar.

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“…Strains of Escherichia coli resistant to multiple antibiotics often predominate in the fecal flora of broiler chickens (2,15). Resistance is generally due to a high incidence of plasmid carriage which causes concern for both animal and public health.…”

mentioning

confidence: 99%

Persistence of an antibiotic resistance plasmid in intestinal Escherichia coli of chickens in the absence of selective pressure

Chaslus-Dancla¹,

Gerbaud²,

Lagorce³

et al. 1987

Antimicrob Agents Chemother

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We studied eight strains of Escherichia coli resistant to high levels of trimethoprim that were isolated over a 6-week period in a commercial breeding flock of broilers. The strains originated from fecal samples and from a carcass immediately after slaughter. Seven of eight strains belonged to the same infrequent biotype. They were also resistant to ampiciRlin and streptomycin, and some were resistant to tetracycline and potassium tellurite. All the strains transferred trimethoprim and ampiciulin resistance to E. coli. Analysis of the donors and of the transconjugants by agarose gel electrophoresis after digestion by restriction endonucleases and by nucleic acid hybridization indicated that resistance to trimethoprim (dfrl) and to ampicillin (bla TEM-1) was mediated by a 65-kilobase plasmid, pIP1531. Persistence of resistance to trimethoprim and ampicilUin in this flock was therefore due to two cumulative factors, both occurring in the absence of selective pressure, namely the dissemination of a particular plasmid between strains and the ability of an atypical E. coli strain to stably colonize many animals.

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Antibiotic Resistance among Escherichia coli O‐serotypes from the Gut and Carcasses of Commercially Slaughtered Broiler Chickens: a Potential Public Health Hazard

Cited by 40 publications

References 27 publications

Antibiotic resistance and R-factors in the fecal coliform flora of urban and rural dogs

Antibiotic resistance and R-factors in the fecal coliform flora of urban and rural dogs

Direct transmission of Escherichia coli from poultry to humans

Persistence of an antibiotic resistance plasmid in intestinal Escherichia coli of chickens in the absence of selective pressure

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