Antibiotic Resistance and Mechanisms of Pathogenic Bacteria in Tubo-Ovarian Abscess

Tang, Huanna; Zhou, Hui; Zhang, Runju

doi:10.3389/fcimb.2022.958210

Cited by 4 publications

(3 citation statements)

References 137 publications

(160 reference statements)

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“…While it can be described as a commensal microbe in the GIT, Peptostreptococcus has pathogenic potential (Murdoch, 1998). It has been previously associated with calf diarrhea (Hennessy et al, 2021), gastrointestinal disease (Tang et al, 2023), and increasing antimicrobial resistance in humans (Tang et al, 2022). In this study, it was also associated with neonatal calf diarrhea, being higher in relative abundance at the time of disease in diarrheic calves.…”

Section: The Fecal Microbiota At Disease Manifestationmentioning

confidence: 52%

Health-associated changes of the fecal microbiota in dairy heifer calves during the pre-weaning period

Scully,

Earley,

Smith

et al. 2024

Front. Microbiol.

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IntroductionNeonatal calf diarrhea is a multifactorial condition that occurs in early life when calves are particularly susceptible to enteric infection and dysbiosis of the gut microbiome. Good calf health is dependent on successful passive transfer of immunity from the dam through colostrum. There are limited studies on the developing gut microbiota from birth to weaning in calves.MethodologyTherefore, the objective of this study was to examine the effect of immune status and diarrheal incidence on the development of the fecal microbiota in Jersey (n = 22) and Holstein (n = 29) heifer calves throughout the pre-weaning period. Calves were hand-fed a colostrum volume equivalent to 8.5% of their birthweight, from either the calf’s dam (n = 28) or re-heated mixed colostrum (≤2 cows, ≤1d; n = 23) within 2 h of birth. All calves were clinically assessed using a modified Wisconsin–Madison calf health scoring system and rectal temperature at day (d) 0, d7, d21, or disease manifestation (DM) and weaning (d83). Weights were recorded at d0, d21, and d83. Calf blood samples were collected at d7 for the determination of calf serum IgG (sIgG). Fecal samples were obtained at d7, d21/DM [mean d22 (SE 0.70)], and at weaning for 16S rRNA amplicon sequencing of the fecal microbiota. Data were processed in R using DADA2; taxonomy was assigned using the SILVA database and further analyzed using Phyloseq and MaAsLin 2.Results and discussionSignificant amplicon sequence variants (ASVs) and calf performance data underwent a Spearman rank-order correlation test. There was no effect (p > 0.05) of colostrum source or calf breed on serum total protein. An effect of calf breed (p < 0.05) was observed on sIgG concentrations such that Holstein calves had 6.49 (SE 2.99) mg/ml higher sIgG than Jersey calves. Colostrum source and calf breed had no effect (p > 0.05) on health status or the alpha diversity of the fecal microbiota. There was a relationship between health status and time interaction (p < 0.001), whereby alpha diversity increased with time; however, diarrheic calves had reduced microbial diversity at DM. No difference (p > 0.05) in beta diversity of the microbiota was detected at d7 or d83. At the genus level, 33 ASVs were associated (adj.p < 0.05) with health status over the pre-weaning period.

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Section: The Fecal Microbiota At Disease Manifestationmentioning

confidence: 52%

Health-associated changes of the fecal microbiota in dairy heifer calves during the pre-weaning period

Scully,

Earley,

Smith

et al. 2024

Front. Microbiol.

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“…The prevalence of PID is 3.6-10%, and 2.3-20% of PID patients may develop TOA. [2] Usually, Chlamydia spp. and Neisseria spp.…”

Section: Introductionmentioning

confidence: 99%

“…The most common resistance mechanisms are modifying the production of hydrolase enzymes, ribosomal protection, and target site mutation. [2] Antibiotherapy failure, rupture of the abscess, and sepsis are the main indications for surgery. Approximately 25% of patients with unruptured TOA require surgery.…”

Section: Introductionmentioning

confidence: 99%

The effect of serum biomarkers on the requirement for surgical intervention in tuboovarian abscess

Satır Özel

2024

Zeynep Kamil Med J

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Objective: Tubo-ovarian abscess (TOA) is a complex infectious mass of the adnexa, which is treated by antibiotherapy or surgery. Antibiotherapy failure may occur during TOA treatment. The aim of this study is to assess the effect of TOA size and serum biomarkers on the requirement for surgical intervention.Material and Methods: Eighty-four patients over five years in our clinic were evaluated. TOA size and laboratory values such as hemoglobin, white blood cell count, lymphocyte, monocyte, platelet, albumin, neutrophil, C-reactive protein (CRP) levels, and if antibiotics were switched to another treatment protocol or changed to a surgical approach, were also reported. Prognostic Nutritional Index (PNI), the platelet-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR), and monocytelymphocyte ratio (MLR) were also used to evaluate medical therapy failure and the requirement for surgery.Results: Eighty-four patients hospitalized with the diagnosis of TOA, 13 of them required surgery due to antibiotherapy failure and the surgical intervention rate was calculated as 15.47%. Platelet count and TOA size were found to be statistically significantly higher and hospital stay was found to be statistically significantly longer in the surgery group. CRP and other laboratory values did not have a statistically significant difference between groups. Among the indexes, only PLR had a statistically significant prediction value (p=0.020). Conclusion:TOA volume and PLR were found to be effective predictors in antibiotherapy failure and surgical intervention.

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Perioperative care of a patient with immune thrombocytopenia purpura undergoing tubo‐ovarian abscess incision and drainage: Case report

Zeng,

Tian

2024

Clinical Case Reports

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Key Clinical MassageTubo‐ovarian abscess (TOA) is a serious health hazard for women, causing severe sepsis. Antimicrobial treatment is effective, but one‐third of patients experience unfavorable outcomes. ITP, an autoimmune condition, can lead to bruising and bleeding. Diagnosing TOA in women of childbearing age is crucial, and combining emergency surgery with ITP patients can increase treatment costs and reduce quality of life. ITP can lead to severe complications, including postoperative hemorrhage, and may require platelet transfusions, glucocorticosteroids, and immunoglobulin. These treatments increase costs, decrease quality of life, and impact prognosis. Preventing ITP is crucial. Patients should be administered blood products based on platelet count and anemia or spontaneous bleeding tendencies. Perioperative blood management should aim for a target platelet level of 30 × 109/L and a hemoglobin concentration of 80 g/L before surgery. Post‐surgery, perioperative care is crucial and vigilant for secondary bleeding.AbstractA tubo‐ovarian abscess (TOA) is a frequently encountered inflammatory mass in therapeutic settings. TOA is a serious consequence of pelvic inflammatory disease (PID) that can lead to severe sepsis. In recent years, the incidence of TOA has increased, presenting a significant health hazard for women. To effectively target the diverse range of bacteria responsible for TOA, it is essential to use antimicrobial medicines that have a wide spectrum of activity. Nevertheless, the efficacy of antibiotic treatment stands at approximately 70%, while a significant proportion of patients, around one‐third, experience unfavorable clinical outcomes necessitating drainage or surgical intervention. Immune thrombocytopenia (ITP) is an autoimmune condition characterized by a marked decrease in the quantity of platelets present in the bloodstream. ITP is characterized by thrombocytopenia, which leads to a heightened susceptibility to bruising and bleeding. The diagnosis of ITP and the prediction of treatment response continue to pose important and persistent issues in the field of hematology. The platelet count is commonly employed as a surrogate indicator of disease severity in patients with ITP and thus plays a crucial role in determining the necessity of treatment. A 25‐year‐old woman with a history of sexual activity underwent open abdominal exploration due to the sudden onset of lower abdominal pain. During the operation, a left TOA was discovered, and an incision and drainage were performed. Symptomatic treatments, such as anti‐infectives and abdominal drainage, were administered. The culture of pus in the abdominal cavity suggested the presence of Escherichia coli. However, the patient presented with ITP and had a platelet count of less than 50 × 109/L before the operation. After the operation, the patient developed incisional and pelvic hematomas with signs of infection. As a result, the patient was discharged from the hospital after undergoing another laparotomy and receiving platelet transfusions and immunotherapy. Clinicians should be vigilant when diagnosing TOA in women of childbearing age, even in the absence of high‐risk factors. A timely antibiotic or surgical intervention is necessary to preserve fertility and ensure quality of life. Combining emergency surgery with ITP patients poses a significant challenge for clinicians in terms of treatment. ITP can lead to serious complications, such as postoperative bleeding, which may require platelet transfusions, glucocorticoids, and immunoglobulin. This can increase the cost of treatment, reduce the quality of life, and seriously affect the prognosis. Therefore, preventing ITP is crucial. It is important to pay attention to the perioperative care of patients after surgery and be alert to the possibility of secondary hemorrhage.

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Antibiotic Resistance and Mechanisms of Pathogenic Bacteria in Tubo-Ovarian Abscess

Cited by 4 publications

References 137 publications

Health-associated changes of the fecal microbiota in dairy heifer calves during the pre-weaning period

Health-associated changes of the fecal microbiota in dairy heifer calves during the pre-weaning period

The effect of serum biomarkers on the requirement for surgical intervention in tuboovarian abscess

Perioperative care of a patient with immune thrombocytopenia purpura undergoing tubo‐ovarian abscess incision and drainage: Case report

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