Antibiotic Resistance and Transfer in Lactic Acid Bacteria

Teuber, Michael; Schwarz, Franziska; Meile, Léo

doi:10.1007/978-1-4615-0191-6_11

Cited by 2 publications

(6 citation statements)

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“…Resistance to tetracycline, chloramphenicol and vancomycin was observed on a 29.8‐kb plasmid in L. lactis isolated from a raw milk soft cheese (Teuber et al , 1999). Of five IS elements identified on the plasmid, three were found to be almost or completely identical to IS 1216 present in the enterococcal vanA resistance transposon Tn 1546 (Arthur & Courvalin, 1994; Teuber et al , 2003).…”

Section: Transposable Elementsmentioning

confidence: 99%

“…Orf 19 of pK214, which encodes the gene product for resistance to streptomycin, has been shown to share 98.8% identity with a streptomycin‐inactivating adenylyl transferase from the S. aureus plasmid, pS194, while Orf 22 has 99.5% identity with the chloramphenicol acetyltransferase (CAT) from the S. aureus plasmid pSBK203 (Teuber et al , 2003). Similarly, the CAT protein was shown to be homologous to the CAT protein identified on the multiresistant plasmid pWDB100 from L. monocytogenes and it is suggested that the tetracycline resistance protein encoded by orf28 is probably derived from L. monocytogenes as well (Teuber et al , 2003). The multidrug transporter, MdtA (previously called Mef214), has 12 membrane‐spanning domains and has the characteristics of an efflux protein (Perreten et al , 2000).…”

Section: Antibiotic Resistancementioning

confidence: 99%

“…This data provides an insight into the DNA shuffling and exchange which can occur between neighbouring bacteria. A review by Teuber et al (2003) discusses pK214 in detail in terms of its overall organization and provides an in‐depth discussion on the phenomenon of acquired antibiotic resistance in LAB.…”

Section: Antibiotic Resistancementioning

confidence: 99%

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Plasmids of lactococci – genetic accessories or genetic necessities?

et al. 2006

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Lactococci are one of the most exploited microorganisms used in the manufacture of food. These intensively used cultures are generally characterized by having a rich plasmid complement. It could be argued that it is the plasmid complement of commercially utilized cultures that gives them their technical superiority and individuality. Consequently, it is timely to reflect on the desirable characteristics encoded on lactococcal plasmids. It is argued that plasmids play a key role in the evolution of modern starter strains and are a lot more than just selfish replicosomes but more essential necessities of intensively used commercial starters. Moreover, the study of plasmid biology provides a genetic blueprint that has proved essential for the generation of molecular tools for the genetic improvement of Lactococcus lactis.

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Section: Transposable Elementsmentioning

confidence: 99%

Section: Antibiotic Resistancementioning

confidence: 99%

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Plasmids of lactococci – genetic accessories or genetic necessities?

et al. 2006

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“…Not only genes of vancomycin resistance may have plasmid or chromosomal localization. Genes coding for several enzymes with phospho-and acetyl-transferase activity involved in aminoglycosides resistance are located on plasmids and chromosome (91).…”

Section: Intrinsic Antibiotic Resistance In Genera Lactococcus and Enmentioning

confidence: 99%

“…One of these genes is bla CTX-M2 found in isolates of E. faecium, although this gene is typical for gram-negative bacteria (102). Сhloramphenicol and erythromycin resistance in E. faecalis is controlled by pRE25 conjugative plasmid (91).…”

Section: Acquired Antibiotic Resistance In Genera Lactococcus and Entmentioning

confidence: 99%

Antibiotic resistance in lactococci and enterococci: phenotypic and molecular-genetic aspects

Plotnikava

Sidarenka

Новик

2017

The EuroBiotech Journal

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Extensive use of antibiotics in medicine, veterinary practice and animal husbandry has promoted the development and dissemination of bacterial drug resistance. The number of resistant pathogens causing common infectious diseases increases rapidly and creates worldwide public health problem. Commensal bacteria, including lactic acid bacteria of genera Enterococcus and Lactococcus colonizing gastrointestinal and urogenital tracts of humans and animals may act as vehicles of antibiotic resistance genes similar to those found in pathogens. Lactococci and enterococci are widely used in manufacturing of fermented products and as probiotics, therefore monitoring and control of transmissible antibiotic resistance determinants in industrial strains of these microorganisms is necessary to approve their Qualified Presumption of Safety status. Understanding the nature and molecular mechanisms of antibiotic resistance in enterococci and lactococci is essential, as intrinsic resistant bacteria pose no threat to environment and human health in contrast to bacteria with resistance acquired through horizontal transfer of resistance genes. The review summarizes current knowledge concerning intrinsic and acquired antibiotic resistance in Lactococcus and Enterococcus genera, and discusses role of enterococci and lactococci in distribution of this feature.

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Antibiotic Resistance and Transfer in Lactic Acid Bacteria

Cited by 2 publications

References 113 publications

Plasmids of lactococci – genetic accessories or genetic necessities?

Plasmids of lactococci – genetic accessories or genetic necessities?

Antibiotic resistance in lactococci and enterococci: phenotypic and molecular-genetic aspects

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