Antibiotic Resistance During Therapy: Mechanisms and Means of Control

Abstract

Antibiotic resistance is a serious public health problem. The most effective way to control this phenomenon is to make rational use of antibiotics. However, antibiotic resistance is a complex process in which clinical, pharmacodynamic, pharmacokinetic and microbiological factors all play a part. Since antibiotic therapy is usually performed empirically, clinicians should follow guidelines that take all these factors into account together with the concepts of evidence based medicine. These guidelines may be elaborated using information technology tools that help to collect, analyze and weigh up all the information available on a certain pathogen. Therefore, the administration of antibiotics should be controlled with the help of multi-disciplinary working groups and in accordance with objective data collected following a thorough analysis of all the available information.

Effect of Dietary Supplementation with Alga (Hizikia fusiformis and Ecklonia cava) on the Non-specific Immune Responses of Parrot Fish Oplegnathus fasciatus

“…어류의 질병 치료는 항생제나 화학요법제에 의존하고 있 지만 항생제의 과도한 사용은 약제 내성균의 확산을 초래하 여 치료를 어렵게 하고 어류의 면역 기능을 저하 시킬 수 있다 (Rodriguez et al, 2007). 이와 같은 문제의 해결 방안으로 어 류의 자체방어능력을 향상시키는 면역증강제의 개발과 친환경 적인 항균물질이나 해양생물자원에서 유래한 기능성 천연 생 리활성물질에 관한 연구도 이루어지고 있다 (Yeh et al, 2006;Divyagnaneswari et al, 2007;Fu et al, 2007).…”

Effects of Antibacterial Peptide Extracted from Bacillus subtilis fmbJ on the Growth, Physiological Response and Disease Resistance of Megalobrama amblycephala

“…The abuse of antibiotics has however been consistently identified as a major risk factor since it results in an increase in the number of antibioticresistant bacteria. This also impacts on the food safety of humans who consume these fish (Cabello, 2006;Rodriguez et al, 2007). As a result, the widespread use of various antibiotic feed additives was banned by the European Union in 1997 (Acar et al, 2000).…”